Studies in both humans and rodents, however, suggest that low testosterone is due to age-related lesions in testes rather than irregular luteinizing hormone metabolism
Group items matching
in title, tags, annotations or url
1More
Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent ... - 0 views
-
Western diet (high trans fats and sugar) linked to altered gut flora and resultant liver inflammation. It would have been nice to have followed inflammatory biomarkers i.e. LPS. This sounds just like metabolic syndrome.
1More
shared by fitspresso on 27 Sep 23
- No Cached
https://www.thefastleanpro.us/ - 0 views
www.thefastleanpro.us
the fast lean pro us usa fastlean fastleanpro caps drops uk buy jar get customer benefits 2023 work scam pros ebay pro2023 drop price
shared by fitspresso on 27 Sep 23
- No Cached
-
Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
1More
Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospec... - 0 views
-
soda intake is associated with increased BMI. Take home, the more soda intake, the higher the obesity. This study looked at children.
1More
Sugar Content of Popular Sweetened Beverages Based on Objective Laboratory Analysis: Fo... - 0 views
-
Fructose content of soda's found to be higher than labeling. The average of HCFS was 59%.
1More
D-chiro-inositol metabolism in diabetes mellitus - 0 views
-
d-chiro-inositol levels shown to be low in diabetics. Thus, d-chiro-inositol would prove to be helpful in diabetes management. D-chiro-inositol is a secondary messenger in insulin signaling
1More
shared by Nathan Goodyear on 19 Sep 13
- No Cached
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the met... - 0 views
ajcn.nutrition.org/...899.short
fructose diabetes hypertension metabolic syndrome cardiovascular disease obesity nutrition
shared by Nathan Goodyear on 19 Sep 13
- No Cached
-
Fructose implicated in just about every chronic disease of aging through obesity.
32More
shared by Nathan Goodyear on 29 Apr 15
- No Cached
PLOS ONE: Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular ... - 0 views
journals.plos.org/...article
hormone hormones low T low Testosterone hypogonadism Testosterone probiotic L reuters probiotics Lactobacillus lactobacillus reuteri male aging
shared by Nathan Goodyear on 29 Apr 15
- No Cached
-
-
Various dietary factors and diet-induced obesity have been shown to increase the risk for late onset male hypogonadism and low testosterone production in both humans and mice
-
Testosterone deficiency and metabolic diseases such as obesity appear to inter-digitate in complex cause-and-effect relationships
- ...28 more annotations...
-
dietary supplementation of aged mice with the probiotic bacterium Lactobacillus reuteri makes them appear to be younger than their matched untreated sibling mice
-
These results indicate that gut microbiota induce modulation of local gastrointestinal immunity resulting in systemic effects on the immune system which activate metabolic pathways that restore tissue homeostasis and overall health
-
all these studies we consistently observed that young and aged mice consuming purified L. reuteri organisms had particularly large testes and a dominant male behavior.
-
The testes of probiotic-fed aged mice were rescued from both seminiferous tubule atrophy and interstitial Leydig cell area reduction typical of the normal aging process. Preservation of testicular architecture despite advanced age or high-fat diet coincided with remarkably high levels of circulating testosterone. The beneficial effects of probiotic consumption were recapitulated by the depletion of the pro-inflammatory cytokine Il-17.
-
feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight
-
mice with dietary L. reuteri supplements were rescued from diet-induced obesity and had normal body weight and lean physique
-
Despite the comparable numbers of ST profiles, we determined that testes from L. reuteri-treated mice had increased ST cross-sectioned profiles
-
the probiotic organism induced prominent Leydig cell accumulations in the interstitial tissue between the ST's
-
The probiotic-associated increase of interstitial Leydig cell areas was sustained with advancing age at 7 (CD vs CD+LR, P = 0.0025; CD+E.coli vs CD+LR, P = 0.0251) and 12 months
-
mice eating L. reuteri had profoundly increased levels of circulating testosterone regardless of the type of diet they consumed
-
blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics
-
previous studies we found that dietary probiotics counteract obesity [19] and age-related integumentary pathology [18] at least in part by down-regulating systemic pro-inflammatory IL-17A-dependent signaling
-
Testes histomorphometry and serum androgen concentration data were both suggestive of a probiotic-associated up-regulation of spermatogenesis in mice
-
Lactobacillus reuteri we discovered that aging male animals had larger testes compared to their age-matched controls
-
xamined testes of probiotic microbe-fed mice and found that they had less testicular atrophy coinciding with higher levels of circulating testosterone compared to their age-matched controls
-
Similar testicular health benefits were produced using systemic depletion of the pro-inflammatory cytokine Il-17 alone, implicating a chronic inflammatory pathway in hypogonadism
-
One specific aspect of this paradigm is reciprocal activities of pro-inflammatory Th-17 and anti-inflammatory Treg cells
-
Feeding of L. reuteri organisms was previously shown to up-regulate IL-10 levels and reduce levels of IL-17 [19] serving to lower systemic inflammation
-
insufficient levels of IL-10 may increase the risk for autoimmunity, obesity, and other inflammatory disease syndromes
-
Westernized diets are also low in vitamin D, a nutrient that when present normally works together with IL-10 to protect against inflammatory disorders
-
Physiological feedback loops apparently exist between microbes, host hormones, and immunity
-
The hormone testosterone has been shown to act directly through androgen receptors on CD4+ cells to increase IL-10 expression
-
studies in both humans and rodents suggest that hypogonadism is due to age-related lesions in testes rather than irregular LH metabolism
-
We postulate that probiotic gut microbes function symbiotically with their mammalian hosts to impart immune homeostasis to maintain systemic and testicular health [34]–[35] despite suboptimal dietary conditions.
-
Dietary factors and diet-induced obesity were previously shown to increase risk for age-associated male hypogonadism, reduced spermatogenesis, and low testosterone production in both humans and mice [2]–[4], [8]–[11], [14]–[17], phenotypic features that in this study were inhibited by oral probiotic therapy absent milk sugars, extra protein, or vitamin D supplied in yogurt.
-
Similar beneficial effects of probiotic microbes on testosterone levels and sperm indices were reported in male mice that had been simultaneously supplemented with selenium
-
L. reuteri-associated prevention of age- and diet-related testicular atrophy correlates with increased numbers and size of Leydig cells
-
the initial changes of testicular atrophy begin to occur in mice from the age of 6 moths onwards [7] and indicates that the trophic effect of L. reuteri on Leydig cells is a key event which precedes and prevents age-related changes in the testes of mice. This effect is reminiscent of earlier studies describing Leydig cell hyperplasia and/or hypertrophy in the mouse and the rat testis that were achievable by the administration of gonadotropins, including human chorionic gonadotropin, FSH and LH
-
Fascinating study on how the addition of Lactobacillus reuteri increased Testicular size, prevented testicular atrophy, increased serum Testosterone production and protected against diet-induced/obesity-induced hypogonadism. This was a mouse model
25More
shared by Nathan Goodyear on 27 Jul 14
- No Cached
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Dis... - 0 views
www.ncbi.nlm.nih.gov/...PMC3448089
dysbiosis diet nutrition metabolic endotoxemia disease inflammation gut
shared by Nathan Goodyear on 27 Jul 14
- No Cached
-
The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
-
Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
-
In obese humans, there is decreased abundance of Bacteroidetes compared to lean individuals
- ...21 more annotations...
-
weight loss in obese individuals results in an increase in the abundance of Bacteroidetes
-
there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
-
Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
-
While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
-
targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
-
The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
-
It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
-
In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
-
LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
-
early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
-
increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
-
mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
-
microbial antigens through the innate immune system are involved in T1D progression
-
The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
-
There is evidence that dietary and microbial antigens independently influence T1D
-
Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
-
breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
-
the composition of the gut microbiota strongly correlates with diet
-
In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
-
diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
-
“Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
-
Nice discussion of how diet, induces gut bacterial change, that leads to metabolic endotoxemia and disease.
1More
The toxic truth about sugar - 0 views
-
Though I disagree with the look to government regulation as the means remedy, but this article nicely supports the health epidemic resultant from glucose and fructose.
2More
CCPHA Research & Reports - 0 views
-
adults who drink one or more sodas or other sugar-sweetened beverages every day are 27 percent more likely to be overweight or obese.
1More
shared by Nathan Goodyear on 19 Aug 11
- No Cached
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views
www.ncbi.nlm.nih.gov/...PMC2673878
insulin sensitivity resistance fructose sugar glucose obesity overweight weight loss
shared by Nathan Goodyear on 19 Aug 11
- No Cached
1More
shared by Nathan Goodyear on 09 Dec 14
- No Cached
Nutrition & Metabolism | Full text | Over-stimulation of insulin/IGF-1 signaling by Wes... - 0 views
www.nutritionandmetabolism.com/...41
cancer nutrition diet sugar carbohydrates insulin IGF-1 acne insulin resistance western diet
shared by Nathan Goodyear on 09 Dec 14
- No Cached
-
Elevated insulin and IGF-1 as a result of the typical western diet results in increased risk of many of the chronic diseases of aging that we see in America--cancer.
3More
shared by Nathan Goodyear on 09 Dec 14
- No Cached
Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views
ajcn.nutrition.org/...1160.full
nutrition diet glycemic index glycemic load cancer breast cancer carbohydrates sugar menopause women premenopause
shared by Nathan Goodyear on 09 Dec 14
- No Cached
-
GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
-
the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
-
High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
13More
Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views
-
HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
-
In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
-
fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
- ...9 more annotations...
-
In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
-
Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
-
Uric acid, a byproduct of fructose degradation,
-
Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
-
Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
-
Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
-
Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
-
Sucrose is a disaccharide that is comprised of fructose and glucose
-
Figure 2
20More
Demystified . . . Human endogenous retroviruses - 0 views
-
HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits
-
However, several HERVs have been implicated in certain cancers and autoimmune diseases
-
HERVs constitute about 1% of the human genome
- ...16 more annotations...
-
Human endogenous retroviruses (HERVs) represent footprints of previous retroviral infection and have been termed “fossil viruses”
-
HERVs possess a similar genomic organisation to present day exogenous retroviruses such as human immunodeficiency virus (HIV) and human T cell leukaemia virus (HTLV)
-
Retroviruses in effect are retrograde, because the flow of genetic information is reversed compared with the normal pathway of molecular biosynthesis—DNA → RNA → protein. Indeed, all retroviruses necessitate the conversion of viral RNA into a cDNA intermediary, which is catalysed by the enzyme reverse transcriptase
-
Overall, human endogenous retroviruses constitute about 1% of the human genome”
-
some HERVs have been implicated in certain autoimmune diseases and cancers
-
A unit of sugar, phosphate, and base is strictly termed a nucleotide
-
human genes are composed of exons, which are transcribed and translated into amino acids
-
introns, which are interspersed between exons and represent non-translated regions that contribute to the large size of some genes
-
convincing argument for the possible involvement of HERVs in malignancy
-
HERVs may be involved in carcinogenesis by virtue of the expression of HERV mRNA,26 functional proteins,27 or retroviral-like particles
-
They may also be associated with the generation of new promoters29 or the activation of proto-oncogenes
-
inhibition of an effective immune response,
-
encode immunosuppressive proteins
-
“It has been suggested that HERV-K may be important in the progression of testicular germ cell tumours through inhibition of an effective immune response”
-
HERV-K might be important in the pathogenesis of human breast cancer
-
activation of proto-oncogenes of the ras family is common in many tumour types, and some studies have suggested a potential role for HERVs in ras activation
10More
shared by Nathan Goodyear on 17 Nov 16
- No Cached
PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice wit... - 0 views
journals.plos.org/...article
ketogenic ketogenic diet ketones ketone bodies cancer nutrition diet hyperbaric oxygen hyperbaric therapy hyperbaric
shared by Nathan Goodyear on 17 Nov 16
- No Cached
-
This finding strongly supports the efficacy of the KD and HBO2T as therapies to inhibit tumor progression and prolong survival in animals with metastatic cancer.
-
We found that the KD fed ad libitum significantly increased mean survival time in mice with metastatic cancer
-
Ketogenic diets are also known to have an appetite suppressing effect which may contribute to body weight loss
- ...5 more annotations...
-
the ketogenic diet may inhibit cancer progression in part by indirect dietary energy restriction
-
KD with HBO2T. Combining these therapies nearly doubled survival time in mice with metastatic cancer,
-
low carbohydrate or ketogenic diets promote weight loss in overweight individuals, they are also known to spare muscle wasting during conditions of energy restriction and starvation
-
dietary-induced therapeutic ketosis in a cancer patient would prevent muscle wasting similarly as it does with athletes undergoing intense exercise
-
when given as an adjuvant treatment to advanced cancer patients, the KD improves quality of life and enhances the efficacy of chemotherapy treatment in the clinic
-
mouse study finds that ketogenic diet plus hyperbaric O2 treatment prolongs survival.
-
Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com
2More
Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras | Nature Communi... - 0 views
-
glucose deprivation triggers apoptosis47 and vitamin C treatment kills RAS-oncogene expressing tumor cells, but not wild-type RAS containing cells, by inhibition of GAPDH
-
New study out of the UK supports the role of glucose in cancer growth and aggressiveness. This research found that high influx of glucose into the glycolysis pathway upregulated the RAS oncogene via accumulation of the Fructose 1,6 bisphosphonate through the enzyme phosphofructokinase..
29More
Communication between genomic and non-genomic signaling events coordinate steroid hormo... - 0 views
-
steroid hormones typically interact with their cognate receptor in the cytoplasm for AR, glucocorticoid receptor (GR) and PR, but may also bind receptor in the nucleus as appears to often be the case for ERα and ERβ
-
This ligand binding results in a conformational change in the cytoplasmic NRs that leads to the dissociation of HSPs, translocation of the ligand-bound receptor to the nucleus
-
In the nucleus, the ligand-bound receptor dimerizes and then binds to DNA at specific HREs to regulate gene transcription
- ...25 more annotations...
-
some steroid hormone-induced nuclear events can occur in minutes
-
the genomic effects of steroid hormones take longer, with changes in gene expression occurring on the timescale of hours
-
Classical steroid hormone signaling occurs when hormone binds nuclear receptors (NR) in the cytoplasm, setting off a chain of genomic events that results in, among other changes, dimerization and translocation to the nucleus where the ligand-bound receptor forms a complex with coregulators to modulate gene transcription through direct interactions with a hormone response element (HRE)
-
NRs have been found at the plasma membrane of cells, where they can propagate signal transduction often through kinase pathways
-
Membrane-localized ER, PR and AR have been reported to modulate the activity of MAPK/ERK, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), nitric oxide (NO), PKC, calcium flux and increase inositol triphosphate (IP3) levels to promote cell processes including autophagy, proliferation, apoptosis, survival, differentiation, and vasodilation
-
ERα36, a 36kDa truncated form of ERα that lacks the transcriptional activation domains of the full-length protein. Membrane-localized ERα36 can activate pathways including protein kinase C (PKC) and/or mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) to promote the progression of various cancers
-
G protein-coupled receptor 30 (GPR30), also referred to as G protein-coupled estrogen receptor (GPER), is a membrane-localized receptor that has been observed to respond to estrogen to activate rapid signaling
-
hormone-responsive G protein coupled receptor is Zip9, which androgens can activate
-
GPRC6A is another G protein-coupled membrane receptor that is responsive to androgen
-
androgen-mediated non-genomic signaling through this GPCR can modulate male fertility, hormone secretion and prostate cancer progression
-
non-NR proteins located at the cell surface can bind to steroid hormones and respond by eliciting rapid signaling events
-
Estrogens have been shown to induce rapid (i.e. seconds) calcium flux via membrane-localized ER (mER)
-
ER-calcium dynamics lead to activation of kinase pathways such as MAPK/ERK which can result in cellular effects like migration and proliferation
-
17β-estradiol (E2) has been reported to promote angiogenesis through the activation of GPER
-
Membrane NRs may also mediate rapid signaling through crosstalk with growth factor receptors (GFR)
-
A similar crosstalk occurs between the receptor tyrosine kinase insulin-related growth factor-1 receptor (IGF-IR) and ERα. Not only does IGF-IR activate ERα, but inhibition of IGF-IR downregulates estrogen-mediated ERα activity, suggesting that IGF-IR is essential for maximal ERα signaling
-
This is a bombshell that shatters the current right brain approach to ER. It completely shatters the concept of eat sugar, whatever you want, with cancer treatment in ER+ or hormonally responsive cancer!
-
-
Further, ER activates IGF-IR pathways including MAPK
-
GPER is involved in the transactivation of the EGFR independent of classical ER
-
tight interconnection between genomic and non-genomic effects of NRs.
-
non-genomic pathways can also lead to genomic effects
-
androgen-bound AR associates with the kinase Src at the plasma membrane, activating Src which then leads to a signaling cascade through MAPK/ERK
-
However, Src can also increase the expression of AR target genes by the ligand-independent transactivation of AR
-
extranuclear steroid hormone actions can potentially reprogram nuclear NR events
-
estrogen modulated the expression of several genes including endothelial nitric oxide synthase (eNOS) via rapid signaling pathways
-
epigenetic changes can then mediate genomic events in uterine tissue and breast cancer cells