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Estrogens appear to have an immune stimulatory effect in the presence of inflammatory cytokines.  The estrogens appear to increase inflammation through activation of NFkappaB.  But of course, not all estrogens are equal.  This article is primarily referencing E2.  I would expect E1 due to its preference for ER alpha, but not E3, due to its ER beta preference.

small study, but oral curcumin tolerated up to 8 grams daily.  The course of this study was 3 months.  

8 grams of oral curcumin shown to benefit pancreatic cancer.  Down regulation of NF-kappaB and cyclooxygenase-2 over the course of the study.  Result varied, but activity against tumor cells without side effects was seen.

Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.

This study tried to see if questionnaires could replaced free Testosterone test to diagnosis hypogonadism.  The answer of course is no.  One needs both to properly assess a individual.

vitamin D plus calcium in those with Diabetes and low vitamin D four to improve insulin resistance, HDL, LDL, beta cell function, and HgbA1c.  This was a short course study of 8 weeks.  Only abstract available.

animal model finds that high fat diet induces ED more through increased Estradiol production than low Testosterone.  Of course the authors focused on the drugs to block E2 once produced, rather then reducing the T to E2 aromatase activity.  This metabolic syndrome model implies that increased aromatase activity will be present.

Sex difference of gut flora has different metabolic effects from the same diet.  Could it all begin in the get?  Are gut flora sexist?  Of course not, but this study highlights the sex difference of the gut flora and the gender different effects.

Study finds link between cholesterol metabolite and breast cancer.  The interesting point of this article is not that statins need to be given to all women to prevent breast cancer, which of course is what many will take.  But, that the cholesterol metabolite, 27-hydroxycholesterol showed ER agonist activity.  This would have to be ER-alpha agonist activity though the authors did not clarify.  The 27-hydroxymetabolite is created from CYP27A1.

High dose IV vitamin C shown to be well tolerated in those on hemodialysis.  Liver enzymes were followed throughout the course of the 6 month trial.  In fact, IV vitamin C was shown to improve the response of the EPO therapy.

New study finds that inactive lifestyle leads to more early deaths than obesity.  Of course, the 2 are interrelated.  The study found a 16-30% reduction in early death due to 20 minutes of walking daily.  This came from analysis of the EPIC study

Animal study finds that an 8 week course of high fat diet (HF) is associated with an increase serum rT3 levels by 1.5 fold.

Short 10 week course of resistance exercise associated with an increase in DHEA and DHEAS in both men and women.

Portable chair frames can be constructed of either steel or aluminum and have weights anywhere from 15 lbs. and 45 lbs. depending on the model. All chairs will fold from side to side and some have folding back the make transporting and storage easier. Most chairs have weight capacity of 250 lbs. But the heavy duty models will hold up to about 450 lbs. Of course, a chair which will hold 450 lbs. Will be a much more heavily constructed and will push the weight towards the 45 lb. weight. The most common wheel configuration for portable chairs is four 8\" casters with solid tires. The front two casters will swivel to enable turning. On some models the rear two wheels may be 12\" in diameter instead of 8\" and have air tires insted of solid tires. The larger wheels will give a little bit softer ride and traverse rough terrain a little better. They fold up in interesting ways to collapse to the size of a suitcase when not in use and are usually large enough to cover one or two stairs when extended. It is important to consider their weight and the person who would most often be carrying the ramp and setting it up. Karma KM 2500 L Big Wheel Wheelchair Karma KM 2500 L Wheelchair Specifications Width 18" Front/Rear Wheels 6" to 22" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 11.kg Karma KM 2500 L Wheelchair Seat and Back AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 L Wheelchair Extended Armrest By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (11 kg) with a compact design for either attendant assisted or

Only abstract available here, but good opinion piece on the future, here and now, in the field of immunotherapy in the treatment of cancer-oncolytic virus. Of course, they focus on the genetic altered virus', yet an unaltered enterovirus currently exists on the market.

study finds nivolumab helpful in some patients with surgically unresectable or metastatic anal cancer.  The dose used was 3 mg/kg every 2 weeks. 

Good review of the SUVs of a PET/CT scan.

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