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Low circulating androgens and mortality risk in heart ... [Heart. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19875366 heart failure mortality DHEA Testosterone men male hormone hormones
shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    low androgens, DHEA and free Testosterone, associated with increased poor prognosis in men with heart failure
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SpringerLink - Heart Failure Reviews, Volume 15, Number 2 - 0 views

www.springerlink.com/...148445g2hv141195 heart thyroid hormone MI heart-attack
shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • Nathan Goodyear on 02 Feb 11
     
    Thyroid hormone helps the heart heal and repair after heart-attack
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Fight Your Heart Disease With Cardiac Surgery India - 0 views

medical-tourism-magazine.blogspot.com/...cardiac-surgery-india.html Cardiac surgery India Heart failure surgeons in India Top 10 heart failure surgeons of India Heart failure surgeons Affordable Cardiac surgery Cardiac Surgery Cost in India Affordable Cardiac Surgery India
shared by indian-health on 06 Sep 22 - No Cached
  • indian-health on 06 Sep 22
     
    The cardiac surgery India has been recognized for offering a new lease of life to patients suffering from various cardiac diseases.
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Thyroid hormone and "cardiac metamorphosis": poten... [Pharmacol Ther. 2008] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...18455802 thyroid hormone heart cardiac
shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • Nathan Goodyear on 02 Feb 11
     
    thyroid hormone plays important role in heart failure and heart repair; thyroid balance critical
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Association of serum androgen concentrations with... [Aging Male. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24805790 heart failure men male hormone hormones aging low T Testosterone free DHEAS SHBG
shared by Nathan Goodyear on 12 May 14 - No Cached
  • Nathan Goodyear on 12 May 14
     
    Men with heart failure have lower Total Testosterone, free Testosterone, DHEAS levels and increased SHBG when compared to those without.
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Wasting syndrome with deep bradycardia as ... [BMC Endocr Disord. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25260871 CVD cardiovascular disease low T low Testosterone low T Testosterone heart failure CHF health men male hormone hormones
shared by Nathan Goodyear on 29 Sep 14 - No Cached
  • Nathan Goodyear on 29 Sep 14
     
    long standing low T linked to bradycardia and heart failure in case series.  Exact relationship of cause/effect unknown, though low T has been shown to be associated with wide spectrum of increased risk of CVD.
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Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure. Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD
shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
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Testosterone and pro-inflammatory cytokines in men with chronic heart failure - 0 views

www.endocrine-abstracts.org/...ea0003p250.htm CHF congestive heart failure men male hormone hormones low T low t low Testosterone Testosterone IL-1beta TNF-alpha inflammation heart failure cardiovascular disease
shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Low bioavailable Testosterone associated with increased IL-1beta and TNF-alpha in men with CHF.
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Therapeutic effect of taurine in congestive heart failure: a double-blind crossover tri... - 0 views

www.ncbi.nlm.nih.gov/...3888464 Taurine CHF congestive heart failure heart heart health
shared by Nathan Goodyear on 22 Jun 16 - No Cached
  • Nathan Goodyear on 22 Jun 16
     
    Taurine an effective adjuvant in treatment of CHF.  Also shown to be safe.
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Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease
shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
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Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms: Expert... - 0 views

www.tandfonline.com/...17512433.2015.1011125 statin statins atherosclerosis CHF CoQ10 selenium vitamin K2 heart health heart failure heart
shared by Nathan Goodyear on 20 Oct 17 - No Cached
  • Nathan Goodyear on 20 Oct 17
     
    Statins cause atherosclerosis, not reverse it.  New study describes the mechanism.
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Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

jcem.endojournals.org/...1172.full free T3 fT3 heart cardiac MI myocardial infarction hypothyroidism hypothyroid CHF congestive heart failure hormone hormones thyroid
shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
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Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Tr... - 0 views

ajp.amjpathol.org/...fulltext Lyme Lyme disease borrelia burgdorferi
shared by Nathan Goodyear on 14 Dec 17 - No Cached
  • In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
  • Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
  • in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
  • ...41 more annotations...
  • colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
  • The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
  • The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
  • In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
  • Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
  • We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
  • The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
  • The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
  • Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
  • we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
  • Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
  • In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
  • This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
  • The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
  • Lyme, Connecticut.
  • Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
  • approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
  • Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
  • ‘post-treatment Lyme disease syndrome’ (PTLDS)
  • host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
  • inflammatory responses to residual antigens from dead organisms
  • residual tissue damage following pathogen clearance;
  • autoimmune responses, possibly elicited by antigenic mimicry
  • Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
  • Ten male rhesus macaques
  • half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
  • Minimal and focal lymphoplasmacytic inflammation
  • inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
  • Minimal localized lymphoplasmacytic choroiditis
  • Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
  • Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
  • For all animals, inflammation was reserved to perineural tissue
  • The treatment lasted 28 days
  • Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
  • A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
  • mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
  • three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
  • 10% to -20% of human patients treated
  • Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
  • and the rapid clearance of dead spirochetes in a murine model
  • higher doses may be needed to combat neuroborreliosis
  • Nathan Goodyear on 14 Dec 17
     
    persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
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Low Cost of Valve Replacement Surgery India Changing Lives of People with Heart Problems - 0 views

www.101pressrelease.com/alve-replacement-surgery-india Low Cost of Valve Replacement Surgery India Valve Replacement Surgery Cost of valve replacement Heart Valve replacement Cardiac Arrest Heart Failure best hospitals for heart valve best hospitals for heart valve replacement in India
shared by indian-health on 22 Nov 22 - No Cached
  • indian-health on 22 Nov 22
     
    The cost of valve replacement surgery India is provided by the top hospitals in India at a very high success rate which can vary between 97 to 99 %
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Exactly How Bad Are Trans Fats | Your Health Our Priority - 0 views

www.fnfdoc.com/...bad-trans-fats Heart Disease Obesity Saturated Fat Trans Fats
shared by fnfdoc on 03 May 18 - No Cached
  • fnfdoc on 03 May 18
     
    Are you worried you are getting heavier day by day? Well, it might be because of those fries you are addicted to. Deep fried foods are rich in trans fats which are directly related to obesity and heart failure. Trans fats build up the blood vessels, hindering the smooth flow of blood through them.
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Role of dopamine in congestive heart failure: a contemporary appraisal. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12189316 dopamin CHF heart failure heart
shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    dopamine has benefit in CHF.  Actually, use to be a therapy employed.
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The role of dopamine receptors in the treatment of congestive heart failure. - PubMed -... - 0 views

www.ncbi.nlm.nih.gov/...2478806 dopamine CHF heart failure heart
shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    Dopamine improves chronic CHF via its interactions with the dopamine receptors.
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Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac rem... - 0 views

onlinelibrary.wiley.com/...abstract T3 thyroid hormone hormones MI mitochondria HIF-1alpha
shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    T3 in the post MI individual decreases the MI infarct size and the progression to heart failure. What is really  interesting about this study is that the T3 induced mitochondrial biogenesis and activity which is a great thing in recovery of MI and also in disease i.e. cancer.  However, it appears to increase HIF-1alpha and angiogenesis which is stimulated by retrograde signaling.  There is a muddied picture here.  Because T3 stimulates oxidative phosphorylation and mitochondria biogenesis which is favorable for health.  However, in this study of rats, it induced HIF-1alpha and angiogenesis in post MI, which is favorable to recovery, yet this is unfavorable for cancer.    Yet oxidative phosphorylation is favorable to cancer prevention/elimination and MI recovery.
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Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

www.ajconline.org/...abstract CHF T3 hypothyroid hypothyroidism heart failure
shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
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JAMA Network | JAMA | Circulating Estradiol and Mortality in Men With Systolic Chronic ... - 0 views

jama.jamanetwork.com/article.aspx CHF heart failure men estradiol male hormone hormones mortality
shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    Study of 500 men with CHF and reduced LVEF found that estradiol has a "U" shaped relationship to prognosis.  A low and high estradiol levels are associated with increased poor prognosis.  Other biomarkers in these 2 groups were different, suggesting different physiologic mechanisms.
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