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Nathan Goodyear

Systematic literature review of the risk factors, ... [Andrology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25269643

cochrane low T low Testosterone aging obesity metabolic syndrome health men male low T Testosterone mortality CVD cardiovascular

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    10 year Cochrane review finds low T associated with aging, obesity, MetS, and poor health.  The authors suggest that low T "may be linked to earlier all-cause and cardiovascular related mortality among men".  This is supported by other studies.  Only abstract available here.
Nathan Goodyear

Late-onset hypogonadism: beyond testosterone Foresta C, Calogero AE, Lombardo F, Lenzi A, Ferlin A - Asian J Androl - 0 views

www.ajandrology.com/article.asp

low T Testosterone low t low Testosterone men male hormone hormones vitamin D calcidiol cholecalciferol 25-hydroxyvitamin D

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    Men with Low T often have Low vitamin D levels.  This study found better results with calcidiol versus cholecalciferol in raising 25-hydroxyvitamin D.
Nathan Goodyear

Late onset hypogonadism of men is not equivalent t... [Maturitas. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25042874

low t low Testosterone low T Testosterone men male hormone hormones

shared by Nathan Goodyear on 23 Jul 14 - No Cached
  • Nathan Goodyear on 23 Jul 14
     
    published ahead of print, so full article is not available.  Abstract points to low T as a result of metabolic factors i.e. obesity, inflammation...This is true.  The authors, in the abstract, point to the differences in Menopause in women versus low T in men.  
Nathan Goodyear

Wasting syndrome with deep bradycardia as ... [BMC Endocr Disord. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25260871

CVD cardiovascular disease low T low Testosterone low T Testosterone heart failure CHF health men male hormone hormones

shared by Nathan Goodyear on 29 Sep 14 - No Cached
  • Nathan Goodyear on 29 Sep 14
     
    long standing low T linked to bradycardia and heart failure in case series.  Exact relationship of cause/effect unknown, though low T has been shown to be associated with wide spectrum of increased risk of CVD.
Nathan Goodyear

Hypogonadal Symptoms Are Associated With Different S... [Urology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25288577

Testosterone total testosterone low T low T low Testosterone hypogonadism men male hormone hormones

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    This study looked at Total Testosterone and prevalence of low T symptoms.  As the authors stated, increased prevalence was found between 320 and 375 ng/dl.  Whereas, < 300 ng/dl was consistent with predictable low T symptoms.  It would have be more thorough if they had looked at salivary Testosterone levels and bioavailable as well.
Nathan Goodyear

Testosterone reduced pain perception in hypogonadism | Endocrine Today - 0 views

www.healio.com/...ain-perception-in-hypogonadism

low T Testosterone pain opiates men male hormone hormones men's health Man Boob Nation

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Study finds that men with opiated induced low T have improvement in pain with Testosterone therapy.  Opiates are one of the many causes of low Testosterone (see my book Man Boob Nation).  low T has been associated with increase inflammation in men.  Thus a normalization of Testosterone would provide anti-inflammatory effects.
Nathan Goodyear

Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men: The Journal of Clinical Endocrinology & Metabolism: Vol 82, No 8 - 0 views

press.endocrine.org/...jcem.82.8.4174

leptin low T low Testosterone low T testosterone obese obesity men male hormone hormones

shared by Nathan Goodyear on 03 Nov 14 - No Cached
  • Nathan Goodyear on 03 Nov 14
     
    Men with low T and elevated Leptin, have Leptin normalized with Testosterone therapy.  In obese men, Leptin is inversely associated with Testosterone.  This points to more cause/effect relationship with low T, elevated Leptin, and obesity in men.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-2585 - 0 views

press.endocrine.org/...jc.2014-2585

low T low Testosterone low Testosterone male men hormone hormones cardiovascular disease CVD diabetes IMT hs-CRP endothelial dysfunction

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Nathan Goodyear on 05 Nov 14
     
    Cross sectional study finds that 1/3 of men with type II diabetes have low T via serum.  low T correlated with higher IMT and hs-CRP.
Nathan Goodyear

Age, Insulin Requirements, Waist Circumference, and Triglycerides P... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25394376

diabetes men male hormone hormones low T Testosterone low T low Testosterone hypogonadism age waist circumference insulin

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    Study looked at low T in men with type 1 Diabetes.  Only abstract available here.  Study finds appx 10% prevalence with age, waist circumference and insulin requirements as predictive of low T in men with type 1 Diabetes.
Nathan Goodyear

The prevalence of prediabetes in population of Polish men with late-onset hypogonadism, The Aging Male, Informa Healthcare - 0 views

informahealthcare.com/...13685538.2014.936000

low T Testosterone low T low Testosterone men male hormone hormones hypogonadism diabetes pre diabetes pre-diabetes

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    Study of late onset of low T in polish men found a significantly increased prevalence of glucose metabolism dysregulation when compared to normal T control group.  In the low T group, Total Testosterone and Free Testosterone levels were decreased. 
Nathan Goodyear

Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than Lower total testosterone in older men: the Health in Men Study - 0 views

eje-online.org/...785.long

metabolic syndrome SHBG low T Testosterone low T low Testosteorne men male hormone hormones health

shared by Nathan Goodyear on 07 Aug 14 - No Cached
  • Nathan Goodyear on 07 Aug 14
     
    low SHBG found to be more associated with metabolic syndrome in older men than low Testosterone.  The study consisted of 2502 men older than 70.  The authors proposed this occurs through the relationship between SHBG and insulin sensitivity.  I think that is a little too simplistic.
Nathan Goodyear

Exogenous testosterone: a preventable cause of male infertility - Crosnoe - Translational Andrology and Urology - 0 views

www.amepc.org/...3145

low T Testosterone low T low Testosterone hormone hormones fertility infertility hypogonadism Hypogonadotropic hog human chorionic gonadotropin clomid

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    very nice case review and discussion of the treatment of low T and low sperm count in men desiring preservation of fertility.  Clomid and HCG are viable options to increase endogenous Testosterone production, though both work via different mechanisms.
Nathan Goodyear

Inverse relationship between serum levels of interleukin-1beta and testosterone in men with stable coronary artery disease. - ResearchGate - 0 views

www.researchgate.net/...stable_coronary_artery_disease

low T low T low Testosterone Testosterone inflammation men male hormone hormones IL-1beta IL-10 cytokines

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    low Total Testosterone and bioavailable Testosterone is associated with increased IL-1beta and IL-10.  This points to low T having a more direct link to increased systemic inflammation in men.
Nathan Goodyear

Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dysfunction, insulin resistance, diabetes, and cardiovascular disease : Hormone Molecular Biology and Clinical Investigation - 0 views

www.degruyter.com/...hmbci.2011.132.xml

men male hormone hormones androgens low T low Testosterone low T Testosterone insulin resistance IR diabetes metabolic syndrome obesity mortality disease cardiovascular

shared by Nathan Goodyear on 12 Aug 14 - No Cached
  • Nathan Goodyear on 12 Aug 14
     
    low Androgens, or low T to be specific, associated with insulin resistance, diabetes, metabolic syndrome, obesity, and mortality.
Nathan Goodyear

The role of testosterone in the m... [J Steroid Biochem Mol Biol. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19444934

low T Testosterone low T low Testosterone lipids glucose diabetes metabolic syndrome SHBG metabolic syndrome IR insulin resistance

shared by Nathan Goodyear on 14 Aug 14 - No Cached
  • Nathan Goodyear on 14 Aug 14
     
    Testosterone plays an important role in glucose and lipid metabolism.  Thus, low Testosterone, will result in increased disruption in the homeostasis of glucose and lipids resulting in increased weight, insulin resistance, diabetes, metabolic syndrome... low SHBG was also shown to be associated with MetS
Nathan Goodyear

Androgen Therapy Improves Insulin Sensitivity and Decreases Leptin Level in Healthy Adult Men With Low Plasma Total Testosterone - 0 views

care.diabetesjournals.org/...2149.extract

low T low Testosterone leptin obesity Testosterone therapy insulin resistance

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • Nathan Goodyear on 22 Oct 14
     
    Three month study of men with low T, found that Testosterone therapy improved insulin sensitivity and reduced leptin levels.  The group of men here were described as "healthy, non-obese men".   Remember, low T is a biomarker of poor health in men, so the authors statement about the study group is inaccurate.  This also points to a relatively quick metabolic effect by Testosterone and a direct effect on insulin receptor effect and adipocyte leptin release.
Nathan Goodyear

Urolithiasis is associated with low serum testosterone levels in men | Otunctemur | Archivio Italiano di Urologia e Andrologia - 0 views

www.pagepressjournals.org/...4580

urolithiasis kidney stones low T low Testosterone men male hormone hormones metabolic syndrome

shared by Nathan Goodyear on 13 Apr 15 - No Cached
  • Nathan Goodyear on 13 Apr 15
     
    low Testosterone is associated with kidney stones in men through increased Metabolic Syndrome.  Better stated, low T is associated with metabolic syndrome and this metabolic dysfunction increased the findings of kidney stones in men.
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

www.ncbi.nlm.nih.gov/...PMC3188559

epigenetics low Testosterone SNPs Testosterone

shared by Nathan Goodyear on 19 Sep 17 - No Cached
  • mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
  • men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
  • The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone &lt;300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
  • ...3 more annotations...
  • The risk of having low serum testosterone concentrations increased by the number of risk alleles with an OR of 1.62 (95% CI, 1.41 – 1.86) for each risk allele (Figure S4). low serum testosterone concentrations were 6.5-times more prevalent in men with ≥3 risk alleles (30.1% prevalence of low serum testosterone) compared to men without any risk allele (4.6% prevalence of low serum testosterone;
  • SNP rs5934505 was associated with serum testosterone without SHBG-adjustment (combined p-value of 1.7×10−9) and with free testosterone (combined p-value of 6.7×10−15), but not with SHBG
  • The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505
  • Nathan Goodyear on 19 Sep 17
     
    Genetic SNP rs5934505 associated with lower total Testosterone and lower calculated free Testosterone.  No effects on SHBG.
Nathan Goodyear

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine | PNAS - 0 views

www.pnas.org/10238

AML leukemia acute myeloid leukemia MDS vitamin C cancer

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Vitamin C alone at concentrations up to 57 μM had little effect on cell growth but was toxic at 228 μM (SI Appendix, Fig. S1B), in line with recent studies of high vitamin C concentrations (125–2,000 μM)
  • In our combination approach, vitamin C increased the effects of low doses of 5-aza-CdR, with 57 μM vitamin C almost doubling the growth inhibition
  • Using the Chou–Talalay method (28), we found that the two compounds indeed acted synergistically, rather than additively, to inhibit cancer cell growth over the physiological ranges of vitamin C in healthy individuals (26–84 μM)
  • ...12 more annotations...
  • These results show that targeting the cancer DNA methylome by combining low-dose 5-aza-CdR and vitamin C stimulates the expression of ERVs, the induction of a cell-autonomous immune activation response, and increased apoptosis of cancer cells
  • The addition of vitamin C to treatment protocols therefore may be a straightforward way to increase the clinical efficacy of such drugs in MDS and leukemia patients
  • Vitamin C deficiency has been seen previously in patients with multiple types of cancer, including hematological malignancies (35⇓–37). We predict that these patients might receive the most benefits from the combination treatment.
  • induction of an innate immune response
  • We therefore measured plasma concentrations of vitamin C in a small number of patients with miscellaneous hematologic malignancies. Strikingly, 58% of patients with hematological neoplasia who were not taking vitamin C supplements had severe vitamin C deficiency (serum concentration &lt;11.4 μM, at which clinical features of scurvy may be manifested) (34), and 33% had vitamin C levels below the normal range
  • it is possible that vitamin C was oxidized to DHA before it was transported into the cells
  • Oral administration of vitamin C should be sufficient for the therapeutic strategy, because the concentrations reported in this study would not require i.v. administration.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 18
       
      This statement lacks a basic understanding of vitamin C pharmacokinetics.
  • Vitamin C is an essential nutrient for humans and has been reported to increase IFN levels in human cells upon virus infection
  • daily treatment with vitamin C alone at physiological concentrations enhanced the expression of viral-defense genes relative to untreated cells
  • When combined with low-dose 5-aza-CdR, physiological concentrations of vitamin C synergistically inhibited cancer-cell growth and induced apoptosis. Such synergy was associated with increased ERV expression and dsRNA in treated cells. The mechanism of action differs from that of vitamin C at higher doses, which involves its pro-oxidant activity, including GSH inhibition, to generate reactive oxygen species
  • This activity has been shown to induce DNA damage and to enhance the sensitivities of myeloid malignancies, multiple myeloma, and cutaneous T-cell lymphoma to arsenic trioxide (41⇓⇓–44). It also can increase chemosensitivity of ovarian cancer cells (27) and selectively kill KRAS or BRAF mutant colorectal cancer cells by inhibiting GAPDH
  • reactive oxygen species
  • Nathan Goodyear on 12 May 18
     
    91% of patients with hematologic malignancies have vitamin C levels that are either low or severly deficient. This study found that vitamin C plus low dose DNA methyltransferase inhibitors have synergistic inhibition of cancer cell proliferation and increased apoptosis.  Unfortunately, the authors claimed that oral vitamin C would be sufficient which indicates an incredible lack of understanding of vitamin C pharmacokinetics.
Nathan Goodyear

Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study - 0 views

jcem.endojournals.org/...179.abstract

low T low testosterone CVD cardiovascular mortality low testosterone T cardiovascular mortality health

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    low free Testosterone found to be associated with decreased CVD.
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