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Nathan Goodyear

Late-onset hypogonadism: beyond testosterone Foresta C, Calogero AE, Lombardo F, Lenzi ... - 0 views

www.ajandrology.com/article.asp

low T Testosterone low t low Testosterone men male hormone hormones vitamin D calcidiol cholecalciferol 25-hydroxyvitamin D

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    Men with Low T often have low vitamin D levels.  This study found better results with calcidiol versus cholecalciferol in raising 25-hydroxyvitamin D.
Nathan Goodyear

Hypercalcemia of malignancy and new treatment options - 0 views

www.ncbi.nlm.nih.gov/...PMC4675637

hypercalcemia calcium cancer

shared by Nathan Goodyear on 11 Sep 18 - No Cached
  • Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
  • ectopic secretion of parathyroid hormone (PTH) has been implicated
  • Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
  • ...22 more annotations...
  • Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
  • 20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
  • Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
  • In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
  • In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
  • Macrophage inflammation protein 1-alpha (MIP 1-alpha)
  • hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
  • 1% of cases
  • increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
  • 1-α-hydroxylase in the kidney, a process regulated by PTH
  • in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
  • this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
  • Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
  • primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
  • an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
  • Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
  • Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
  • mildly symptomatic disease
  • marked symptoms
  • hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
  • denosumab
  • Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
  • Nathan Goodyear on 11 Sep 18
     
    hypercalcemia in cancer and treatments.
Nathan Goodyear

Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Tran... - 0 views

endo.endojournals.org/...609.abstract

thyroid hormone hormones T3 vitamin D

shared by Nathan Goodyear on 13 Feb 13 - No Cached
  • Nathan Goodyear on 13 Feb 13
     
    T3 can suppress kidney production of 1 alpha,25-dihyddroxyvitamin D.
Nathan Goodyear

Arch Intern Med -- Abstract: Association Between Serum 25-Hydroxyvitamin D Level and Up... - 0 views

archinte.ama-assn.org/...384

vitamin D vitamin D respiratory infections URI cold flu influenza

shared by Nathan Goodyear on 14 Dec 11 - Cached
  • Nathan Goodyear on 14 Dec 11
     
    Vitamin D levels are inversely associated with respiratory infections.  The lower your vitamin D, the higher your risk of respiratory infections.
Nathan Goodyear

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D and Postoperative Outcome in Cardiac Surge... - 0 views

press.endocrine.org/...jc.2014-3013

vitamin D CVD cardiovascular disease heart health cerebrovascular CVA surgery

shared by Nathan Goodyear on 14 Jan 15 - No Cached
  • Nathan Goodyear on 14 Jan 15
     
    low vitamin D predicts increased risk of Major adverse cardiac and/or cerebrovascular events after cardiac surgery.  The definition of low D was <30.  A better study would have been to stratify by 10s the risk.
Nathan Goodyear

25-Hydroxyvitamin D, Parathyroid Hormone, and Mortality in Black and White Older Adults... - 0 views

jcem.endojournals.org/...4156.abstract

vitamin D D3 mortality cancer cardiovascular adults hormone

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    low vitamin D and PTH in black and white elderly associated with increased mortality; however, the black elderly have lower vitamin D levels in comparison to their white counterparts.  How does this play a in increased advanced disease?  I believe quite a bit.
Nathan Goodyear

Maternal 25-Hydroxyvitamin D and Preterm Birth in Twin Gesta... : Obstetrics & Gynecology - 0 views

journals.lww.com/...nd_Preterm_Birth_in.99784.aspx

vitamin D PTD preterm delivery pregnancy

shared by Nathan Goodyear on 07 Jun 13 - No Cached
  • Nathan Goodyear on 07 Jun 13
     
    vitamin D associated with increased Pre term delivery in twin pregnancies.  This is a cohort, so not the most reliable of study designs, but known that vitamin D inhibits inflammation and that this plays a role in labor...logic makes sense.
Nathan Goodyear

Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of... - 0 views

aje.oxfordjournals.org/...aje.kws243.short

vitamin D type I DM diabetes DM

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    Increased type I DM in white military personal with low vitamin D.  The lower the vitamin D, the higher the risk.
Nathan Goodyear

Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific... - 0 views

www.bmj.com/bmj.k671

vitamin D cancer

shared by Nathan Goodyear on 15 Mar 18 - No Cached
  • Nathan Goodyear on 15 Mar 18
     
    New Study from BMJ finds that higher vitamin D levels are associated with a decreased relative risk for total cancer.  The most significant inverse association was found with risk of liver cancer. The study divided the vitamin D levels into quartiles.
Nathan Goodyear

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation ... - 0 views

press.endocrine.org/...jc.2016-2869

vitamin d pregnancy

shared by Nathan Goodyear on 02 Nov 16 - No Cached
  • Nathan Goodyear on 02 Nov 16
     
    Vitamin D support must be customized and followed at all times, but this study looked specifically at pregnancy.
Nathan Goodyear

Effect of vitamin D supplement on depression scores in people with low levels of serum ... - 0 views

bjp.rcpsych.org/...bjp.bp.111.104349.abstract

vitamin vitamin d supplement depression

shared by Nathan Goodyear on 11 Aug 12 - No Cached
  • Nathan Goodyear on 11 Aug 12
     
    Low vitamin D levels associated with more depression; However, vitamin D3 treatment did not improve depression symptoms.
Nathan Goodyear

International Journal of Obesity - The link between obesity and low circulating 25-hydr... - 0 views

www.nature.com/...ijo2011119a.html

obesity vitamin D vitamin D

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    low vitamin D associated with obesity.  Exact relationship is yet to be determined.
Nathan Goodyear

Association between low 25-hydroxyvitamin D, insulin r... [Lupus. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25216653

vitamin D vitamin D insulin insulin resistance BMI women lupus

shared by Nathan Goodyear on 15 Sep 14 - No Cached
  • Nathan Goodyear on 15 Sep 14
     
    low Vitamin D associated with insulin resistance in women with Lupus.  This was found to be independent of weight.  
Nathan Goodyear

Review: The Impacts of Circulating 25-Hydroxyvitamin D Levels on Cancer Patient Outcome... - 0 views

press.endocrine.org/...jc.2013-4320

cancer vitamin D vitamin D

shared by Nathan Goodyear on 09 Jul 14 - No Cached
  • Nathan Goodyear on 09 Jul 14
     
    meta-analysis, so take it for what it is worth; but higher vitamin D levels at the time of diagnosis were associate with better outcomes in those with cancer.  The improved outcomes included cancer mortality, disease-free survival, and overall survival.
Nathan Goodyear

Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18348447

Vitamin D health disease

shared by Nathan Goodyear on 18 Feb 16 - No Cached
  • Nathan Goodyear on 18 Feb 16
     
    increasing vitamin D levels associated with increasing health.
Nathan Goodyear

PLOS ONE: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated w... - 0 views

journals.plos.org/...article

vitamin D cancer health women women's health

shared by Nathan Goodyear on 08 Apr 16 - No Cached
  • Nathan Goodyear on 08 Apr 16
     
    Higher vitamin D levels associated with decreased risk of cancer in women--67% decrease.
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