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in title, tags, annotations or urlHypoxic control of metastasis - 0 views
Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activation - 0 views
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consumption of this particular diet for at least a 2-month period helped to reduce the outcomes of both acute and chronic inflammation induced by LPS.
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chronic inflammation compromised both glucose and insulin tolerance, which is normally seen in certain chronic metabolic diseases
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LPS resulted in an increase in neopterin levels, which is a marker for immune system activation
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The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling. - Abstract - Europe PMC - 0 views
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we wanted to investigate if other molecular targets and pathways may be used by SARS-CoV-2. We investigated the possibility of the spike 1 S protein and its receptor-binding domain (RBD) to target the epidermal growth factor receptor (EGFR) and its downstream signaling pathway in vitro using the lung cancer cell line (A549 cells). Protein expression and phosphorylation were examined upon cell treatment with the recombinant full spike 1 S protein or RBD. We demonstrate for the first time the activation of EGFR by the Spike 1 protein associated with the phosphorylation of the canonical Extracellular signal-regulated kinase1/2 (ERK1/2) and AKT kinases and an increase in survivin expression controlling the survival pathway.
Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach - ScienceDirect - 0 views
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Targeting the IDO1 pathway in cancer: from bench to bedside | Journal of Hematology & Oncology | Full Text - 0 views
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Kyn is generated via two major routes: in peripheral tissues, controlled by the rate-limiting enzymes indoleamine 2, 3-dioxygenase 1 (IDO1) and indoleamine 2, 3-dioxygenase 2 (IDO2), and the hepatic route, in which tryptophan 2, 3-dioxygenase (TDO) is the rate-limiting enzyme
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