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Nathan Goodyear

Healthy Plant-Based Diets Are Associated with Lower Risk of All-Cause Mortality in US A... - 0 views

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    Plant based diet associated with a reduction in overall all-cause mortality.
Nathan Goodyear

The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum HDL levels ... - 0 views

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    Study finds a decrease in metabolic syndrome parameters with a low-fat, plant-based diet.  Also of note, HDL decreased.
Nathan Goodyear

A plant-based diet for type 2 diabetes... [Diabetes Educ. 2010 Jan-Feb] - PubMed - NCBI - 0 views

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    low fat, but particularly a plant-based diet reduces body weight and improves glucose control.
Nathan Goodyear

Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activ... - 0 views

  • consumption of this particular diet for at least a 2-month period helped to reduce the outcomes of both acute and chronic inflammation induced by LPS.
  • chronic inflammation compromised both glucose and insulin tolerance, which is normally seen in certain chronic metabolic diseases
  • LPS resulted in an increase in neopterin levels, which is a marker for immune system activation
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  • diet enriched in fruits and vegetables (and consequently phytochemicals) was able to reverse the process and maintain and even elevate insulin sensitivity and glucose tolerance
  • LPS-mediated effects are related to an increase in TLR4 levels that triggers the activation of nuclear factor-kB (NF-kB), a transcription factor that activates a cascade of inflammatory mediators [41]. These factors control the transcription of inflammatory mediators, such as IL-1β, IL-6, TNF-α, TNF-β, INF-α, INFβ, INF-γ
  • Inflammation can alter insulin action and give rise to diabetes and obesity by blocking insulin receptor downstream events, impairing insulin receptor substrate 1 (IRS-1) activation and phosphatidylinositol 3-kinase-dependent (PI3K) pathways, therefore compromising insulin signaling
  • systemic inflammation (generated by LPS) also increased neopterin levels in the urine and resulted in altered neuronal activity by decreasing dopamine (DA) metabolism
  • an increase in neopterin levels has been recognized a sensitive biomarker for immune system activation
  • Our experiments denoted that these diets were able to diminish inflammatory mediators and oxidative damage
Nathan Goodyear

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers - 0 views

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    vitamin C + calorie-restricted plant-based diet found to inhibit KRAS colorectal cancer cell growth in mouse model.
Nathan Goodyear

Nutritional Modulation of Insulin Resistance - 0 views

  • Five branched chain and aromatic amino acids (isoleucine, leucine, valine, tyrosine, and phenylalanine) showed significant associations with future diabetes
  • there is increasing evidence that longer term high-protein intake may have detrimental effects on insulin resistance [68, 117–123], diabetes risk [69], and the risk of developing cardiovascular disease
  • high-protein and the high GI diets significantly increased markers of low-grade inflammation
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  • significant and clinically relevant worsening of insulin sensitivity with an isoenergetic plant-based high-protein diet
  • healthy humans that are exposed to amino acid infusions rapidly develop insulin resistance
  • longer term high-protein intake has been shown to result in whole-body insulin resistance [68, 118], associated with upregulation of factors involved in the mammalian target of rapamycin (mTOR)/S6K1 signalling pathway [68], increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover [118] and stimulation of gluconeogenesis [68, 118].
  • it was recently shown in a large prospective cohort with 10 years followup that consuming 5% of energy from both animal and total protein at the expense of carbohydrates or fat increases diabetes risk by as much as 30% [69]. This reinforces the theory that high-protein diets can have adverse effects on glucose metabolism.
  • Another recent study showed that low-carbohydrate high-protein diets, used on a regular basis and without consideration of the nature of carbohydrates or the source of proteins, are also associated with increased risk of cardiovascular disease [70], thereby indicating a potential link between high-protein Western diets, T2DM, and cardiovascular risk.
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    macronutrient intake and effect on glucose regulation and thus metabolism.
snehr09

Healthy Life Health | Write For Us - 0 views

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    Avocados are superfoods that fight cancer, provide protein and several vitamins to the body. They have abundant proportions of fiber, potassium, and good fats that promote weight loss. Read about the extraordinary benefits of including avocados in your daily diet.
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