Vitamin D3 replacement was found to decrease fasting glucose, decrease insulin, increase insulin sensitivity, and decrease total cholesterol and LDL in pregnant women with gestational diabetes. The dosing here was 50,000 IU x 2 doses taken 3 weeks apart.
Testosterone therapy, undecanoate in this study, found to improve body weight, decrease waist circumference, BMI, lower Total Cholesterol, lower triglycerides, decrease fasting glucose, decrease HgbA1c, decrease blood pressure and increase HDL in men >59.
Chronic prostattis in men associated with prostate cancer. Even more concerning, is the increase in high Gleasons score prostate cancer. This is no surprise as inflammation will increase aromatase activity in the prostate which will increase estrogen production which has been shown to be carcinogenic.
Triptolide, a component of thunder god vine (Tripterygium wilfordii) found to counter ovarian cancer through decreased matrix metalloproteinase 7 and 19 as well as increasing E-cadherin. This effect reduces invasion and spread of cancer.
This study tried to see if questionnaires could replaced free Testosterone test to diagnosis hypogonadism. The answer of course is no. One needs both to properly assess a individual.
Obstructive Sleep apnea (OSA) is associated with low Testosterone levels in men. This study found that Testosterone therapy not only did not improve OSA, but actually worsened OSA.
Weight loss has been shown to improve Testosterone levels in men. This study finds that sleeve gastrectomy improves Testosterone. This is a indirect effect.
severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms. These patients were clearly not hyperthyroid. This fits with other data that points to increased inflammation and reduced TSH levels. Increased inflammation is associated with increased depression.