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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

The itinerary of Streptococcus gallolyticus infection in patients with colonic malignan... - 0 views

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    Streptococcus gallolyticus is an opportunistic infection and associated with colorectal cancer.
Nathan Goodyear

Effects of vitamin D supplementation on gluco... [Am J Clin Nutr. 2013] - PubMed - NCBI - 0 views

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    Vitamin D3 replacement was found to decrease fasting glucose, decrease insulin, increase insulin sensitivity, and decrease total cholesterol and LDL in pregnant women with gestational diabetes.  The dosing here was 50,000 IU x 2 doses taken 3 weeks apart. 
Nathan Goodyear

2013: Student-faculty research suggests Oreos can be compared to drugs of abuse in lab ... - 0 views

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    Rat study suggests that sugar is just as addictive as cocaine.  So, is the food industry knowingly pushing addiction on the public?
Nathan Goodyear

A practical guide to male hypogonadism in the primary care setting - 0 views

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    Good, but limited study to the incidence of low T in men.  
Nathan Goodyear

Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates... - 0 views

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    Total prevalence of low Testosterone in this study was 12.3% per 1,000 person years.  With increasing age, comes decreasing Tesosteorne levels in men.
Nathan Goodyear

Prevalence of Symptomatic Androgen Deficiency in Men: The Journal of Clinical Endocrino... - 0 views

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    Prevalence of low T is 5-10% based on this study from 2007.
Nathan Goodyear

Long-Term Testosterone Treatment in Elderly Men wi... [J Sex Med. 2014] - PubMed - NCBI - 0 views

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    Testosterone therapy, undecanoate in this study, found to improve body weight, decrease waist circumference, BMI, lower Total Cholesterol, lower triglycerides, decrease fasting glucose, decrease HgbA1c, decrease blood pressure and increase HDL in men >59.  
Nathan Goodyear

Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate C... - 0 views

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    Chronic prostattis in men associated with prostate cancer.  Even more concerning, is the increase in high Gleasons score prostate cancer.  This is no surprise as inflammation will increase aromatase activity in the prostate which will increase estrogen production which has been shown to be carcinogenic.
Nathan Goodyear

Triptolide inhibits colon-rectal cancer cells ... [Phytomedicine. 2012] - PubMed - NCBI - 0 views

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    Triptolide, active component of chinese herb thunder god vine, found to inhibit growth of cool-rectal cancer cells.
Nathan Goodyear

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloprotein... - 0 views

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    Triptolide, a component of thunder god vine (Tripterygium wilfordii) found to counter ovarian cancer through decreased matrix metalloproteinase 7 and 19 as well as increasing E-cadherin. This effect reduces invasion and spread of cancer.
Nathan Goodyear

PLOS ONE: Triptolide Inhibits the Proliferation of Prostate Cancer Cells and Down-Regul... - 0 views

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    Thunder god vine, Tripterygium wilfordii, found to inhibit tumor growth.  This study specifically looked at prostate cancer cell lines.
Nathan Goodyear

Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of activ... - 0 views

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    Thunder god vine found to equal the effects of methotrexate in the treatment of rheumatoid arthritis joint pain.
Nathan Goodyear

Performance of Massachusetts Male Aging Study (MM... [Aging Male. 2014] - PubMed - NCBI - 0 views

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    This study tried to see if questionnaires could replaced free Testosterone test to diagnosis hypogonadism.  The answer of course is no.  One needs both to properly assess a individual.
Nathan Goodyear

The relationship between ... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Obstructive Sleep apnea (OSA)  is associated with low Testosterone levels in men.  This study found that Testosterone therapy not only did not improve OSA, but actually worsened OSA.
Nathan Goodyear

Laparoscopic sleeve gastrectomy im... [Chirurgia (Bucur). 2014 Mar-Apr] - PubMed - NCBI - 0 views

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    Weight loss has been shown to improve Testosterone levels in men.  This study finds that sleeve gastrectomy improves Testosterone.  This is a indirect effect.  
Nathan Goodyear

Sex steroids and cardiovascular disease - 0 views

  • T circulates bound with high affinity to sex hormone binding globulin (SHBG) and with lower affinity to albumin, with a small fraction unbound or free
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases
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    Previously posted article.  The journal changed the URL
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Trends in Androgen Prescribing in the United St... - 0 views

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    Startling statistic--25% of men started on Testosterone therapy have had not diagnostic evaluation of Testosterone levels.
Nathan Goodyear

Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years - NEJM - 0 views

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    Increasing mercury exposure associated with increasing tics in children.
Nathan Goodyear

Late-Onset Hypogonadism and Mortality in Aging Men: The Journal of Clinical Endocrinolo... - 0 views

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    severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

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    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
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