Skip to main content

Home/ Dr. Goodyear/ Group items tagged rectal

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Triptolide inhibits colon-rectal cancer cells ... [Phytomedicine. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22464014

colorectal cancer cancer colon rectal triptolide thunder god vine natural

shared by Nathan Goodyear on 21 Apr 14 - No Cached
  • Nathan Goodyear on 21 Apr 14
     
    Triptolide, active component of chinese herb thunder god vine, found to inhibit growth of cool-rectal cancer cells.
Nathan Goodyear

The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spastici... - 0 views

pubmed.ncbi.nlm.nih.gov/8897084

rectal bioavailability THC

shared by Nathan Goodyear on 03 Jun 21 - No Cached
  • Nathan Goodyear on 03 Jun 21
     
    Rectal delivery outperforms oral
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Vegetarian Dietary Patterns and the Risk of Col... - 0 views

archinte.jamanetwork.com/article.aspx

cancer diet nutrition vegetarian colon cancer colorectal cancer rectal cancer

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Vegeterian diet found to reduce colon, colorectal, and rectal cancer when compared to non-vegetarian diets.
Nathan Goodyear

Current Challenges and Opportunities for Improved Cannabidiol Solubility - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC10572536

cannabidiol cancer CBD rectal suppository

shared by Nathan Goodyear on 02 Apr 24 - No Cached
  • Nathan Goodyear on 02 Apr 24
     
    15 to 50% bioavailability from rectal CBD suppository.
Nathan Goodyear

Mifepristone May Halt Progression of Extensively Metastatic Human Adenocarcinoma of the... - 0 views

ar.iiarjournals.org/...1611.full

mifepristone colon colorectal cancer progesterone hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Interesting presentation of 2 case studies where by mifepristone was used in the treatment of late stage colo-rectal cancer.  The authors even propose a potential mechanism where by inhibition of progesterone signaling resulted in increased NK activity.
Nathan Goodyear

The mineral selenium proves itself as powerful anti-cancer medicine - 0 views

www.naturalnews.com/016446.html

selenium cancer

shared by Nathan Goodyear on 12 May 11 - Cached
  • In a December 1996 article in the Journal of the American Medical Association, Dr. Larry Clark presented evidence that supplemental selenium could reduce cancer death rates by as much as 50%
  • patients receiving selenium had a 67% decrease in cancer of the prostate, a 58 percent decrease in colon or rectal cancer and a 45% decrease in lung cancer
  • An article in the Journal of the American Medical Association (JAMA) by Clark et al. (1996) showed that 200 mcg of supplemental selenium a day reduced overall cancer mortality by 50% in humans compared to a placebo group not receiving supplemental selenium
  • ...10 more annotations...
  • In a recent five-year study of nearly 30,000 rural Chinese people, researchers from the NCI found that daily doses of these three nutrients reduced cancer deaths by 13%.
  • In a study in Cancer Letters (Evangelou et al. 1997), animals with malignant tumors given high doses of vitamins C and E and selenium manifested a significant prolongation of the mean survival time. Complete remission of tumors developed in 16.8% of the animals
  • cities and states with high selenium content in the soil also had significantly lower rates of cancer, especially of the digestive and urinary systems.
  • In one study of hundreds of men, a daily intake of 200 micrograms of selenium cut the incidence of prostate cancer by 60 percent.
  • The statistics for breast cancer are particularly striking. "The higher the selenium, the lower the breast cancer
  • In Yugoslavia, scientists studied 33 patients with breast cancer. These women had selenium levels in their bloodstream only half those of healthy volunteers.
  • The overall reduction in cancer incidence was 37% in the selenium-supplemented group; a 50% reduction in cancer mortality was observed over a 10-year period
  • The following are the site-specific reductions in cancer incidence observed in the study: colon-rectal cancers (58%), lung cancer (46%), and prostate cancer (63%)
  • A selenium deficiency appears to increase the risk of prostate cancer fourfold to fivefold
  • It was determined that, as the male population ages, selenium levels decrease, paralleling an increase in prostate cancer
  • Nathan Goodyear on 12 May 11
     
    exhaustive discussion selenium deficiency and increased cancer risk
Nathan Goodyear

Intravenous Fluid Use in Athletes - 0 views

www.ncbi.nlm.nih.gov/...PMC3435915

IV intravenous fluid nutrition athletes athlete sports medicine sports exercise

shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • Treatment of exercise-associated hyponatremia with hypertonic IV infusion to correct plasma sodium levels is also a standard and accepted use of IV fluid infusions
  • athletes who present for medical care with hypernatremia who cannot tolerate oral fluids can benefit from IV fluids
  • Vaporization of sweat accounts for 80% of heat loss in hot, dry atmospheric conditions. This mechanism of water loss is the major contributor for exercise-associated dehydration
  • ...30 more annotations...
  • The rate of water loss can be quantified through measurement of sweat rate
  • Pre- and postexercise body weight measurements are the most common means to estimate overall water loss but are condition specific
  • It appears that 1% to 2% body weight loss is well tolerated by the exercising athlete
  • Dehydration, defined as greater than 2% loss of body weight, can negatively affect performance
  • In highly trained endurance athletes, plasma volume and sodium serum concentration were preserved despite a 5% body weight loss
  • In Ironman triathletes, dehydration to 5% body weight loss did not correlate with occurrence of medical complications
  • hydration should begin hours prior to exercise, especially if known deficits are present, and fluids should be consumed at a slow, steady rate, with 5 to 7 mL/kg taken 4 hours prior to exercise
  • Sodium concentration did not produce significant changes in the rate of absorption but was primarily dependent on carbohydrate concentration
  • Replacing 150% of body weight loss over 60 minutes has been tolerated without complications
  • IV treatment of severe dehydration (>7% body weight loss), exertional heat illness, nausea, emesis, or diarrhea, and in those who cannot ingest oral fluids for other reasons, is clinically indicated
  • A recent survey of the National Football League teams revealed that 75% (24 of 32) of the teams utilized IV infusion of fluids for prehydration in at least some otherwise healthy individuals
  • In the National Football League, an average of 1.5 L of normal saline was administered approximately 2.5 hours prior to competition
  • after 2 hours of exercise, the rectal temperature was 0.6° higher in the group not receiving IV infusion. Also, stroke volume and cardiac output were 11% to 16% lower in the control group versus the IV infusion group.
  • Recent evidence suggests the etiology of EAMC is related to muscle fatigue and neuronal excitability
  • no correlation between hydration status or electrolyte concentrations with EAMC
  • there may be a subset of muscle cramping that is associated with a loss of both body fluid and sodium
  • Glycerol is the primary agent for oral hyperhydration
  • elevation of plasma volume by 200 to 300 mL via dextran infusion resulted in 15% increase in stroke volume, 4% increase in VO2 max, and an increase in the exercise time to fatigue
  • Neither the tonicity nor mode of hydration resulted in improved speed of rehydration, greater fluid retention, or improved performance
  • There are beneficial anecdotal reports of EAMC treatment in elite and professional-level athletes with IV hydration during the course of an event
  • Plasma volume was better restored during rehydration with IV fluids at preexercise and 5 minutes of exercise. At 15 minutes, there was no difference between IV and oral rehydration
  • More rapid restoration of plasma volume was accomplished in the IV treatment group with no advantages over oral rehydration in physiological strain, heat tolerance, ratings of perceived effort, or thermal sensations
  • No difference was found in exercise time to exhaustion. IV and oral rehydration methods were equally effective. Heart rates were statistically higher in the oral rehydration group through 75 minutes of exercise, and there were higher increases in norepinephrine plasma concentrations
  • No significant differences between the groups were found for time to recovery, number of days with pain, number of days with stiffness, sleep disturbance, fatigue, rectal temperature, and loss of appetite
  • The current data suggest that IV rehydration is faster than oral
  • There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
  • Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
  • The use of IV fluid may be beneficial for a subset of fluid sensitive athletes
  • this should be reserved for high-level athletes with strong histories of symptoms in well-monitored settings.
  • Volume expanders may also be beneficial for some athletes
  • Nathan Goodyear on 13 Jan 15
     
    to be read
Nathan Goodyear

Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neopla... - 0 views

www.ncbi.nlm.nih.gov/...PMC6182444

gut microbiome gastric cancer colon cancer gut microbiota rectal cancer

shared by Nathan Goodyear on 02 Apr 24 - No Cached
  • Nathan Goodyear on 02 Apr 24
     
    Microbiome differs between the 3 types.
Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

www.ncbi.nlm.nih.gov/...PMC3891651

Testosterone replacement transdermal low T male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
  • ...13 more annotations...
  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
Nathan Goodyear

http://www.scielo.oces.mctes.pt/pdf/ge/v13n3/v13n3a06 - 0 views

www.scielo.oces.mctes.pt/...v13n3a06

streptococcus gallolyticus colon polyps rectal colorectal

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    People with Streptococcus gallolyticus found to be associated with higher incidence of colon polyps.  This in light of the known association between Steptococcus gallolyticus and colorectal cancer puts a target on Steptococcus gallolyticus in those at risk for colorectal cancer.
Nathan Goodyear

The itinerary of Streptococcus gallolyticus infection in patients with colonic malignan... - 0 views

www.thelancet.com/...abstract

Streptococcus gallolyticus gut bacteria colon rectal cancer colorectal disease

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Streptococcus gallolyticus is an opportunistic infection and associated with colorectal cancer.
Nathan Goodyear

The role of physical activity in c... [Oncology (Williston Park). 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23909073

breast cancer colon rectal colorectal exercise survival rates

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Increased survival seen in those with breast cancer that walk 3 hours weekly.  In colorectal cancer, a decrease in mortality was seen in walking 6 hours weekly.
Nathan Goodyear

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3448089

dysbiosis diet nutrition metabolic endotoxemia disease inflammation gut

shared by Nathan Goodyear on 27 Jul 14 - No Cached
  • The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
  • Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
  • In obese humans, there is decreased abundance of Bacteroidetes compared to lean individuals
  • ...21 more annotations...
  • weight loss in obese individuals results in an increase in the abundance of Bacteroidetes
  • there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
  • Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
  • While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
  • targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
  • The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
  • It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
  • In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
  • LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
  • early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
  • increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
  • mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
  • microbial antigens through the innate immune system are involved in T1D progression
  • The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
  • There is evidence that dietary and microbial antigens independently influence T1D
  • Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
  • breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
  • the composition of the gut microbiota strongly correlates with diet
  • In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
  • diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
  • “Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
  • Nathan Goodyear on 27 Jul 14
     
    Nice discussion of how diet, induces gut bacterial change, that leads to metabolic endotoxemia and disease.
Nathan Goodyear

Associations between ERα, ERβ, and AR Genotypes and Colon and Rectal Cancer - 0 views

cebp.aacrjournals.org/...2936.full.pdf+html

colon cancer colorectal cancer ER ER alpha ER-alpha ER beta ER-beta HRT estrogen receptors

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Study finds ER-beta plays more significant role in the development of Colon cancer than ER-alpha in women.  HRT in women reduces colon cancer risk in comparison to breast, which is increased.  Shows the different tissue expression of ER-alpha and ER-beta, as well as the HRT itself.
1 - 20 of 28 Next ›
Showing 20▼ items per page