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La Creatinina 3.9 en la Enfermedad Renal es Puede Reversible - 0 views

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    La creatinia 3.9 en la enfermedad renal es puede reversible?De hecho, el alto nivel de creatinina es uno de los síntomas más comunes de la enfermedad renal, casi todos los pacientes de la enfermedad de riñón experimentará él, por lo que el tratamiento de la misma está preocupada por muchas personas.Entonces es creatinina 3.9 en la enfermedad renal crónica reversible?En caso afirmativo, cómo revertirla?
Nathan Goodyear

Impaired Peripheral Conversion of Thyroxine to Trhodothyronine - Annual Review of Medic... - 0 views

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    peripheral conversion of t4 to reverse t3
Nathan Goodyear

Use of clomiphene citrate to reverse premature and... [Fertil Steril. 2003] - PubMed re... - 0 views

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    clomid used to reverse hypogonadism in male with prior anabolic abuse
Nathan Goodyear

Improvement in semen quality associated with decreasing occupational lead exposure - Vi... - 0 views

  • These results support the notion that occupational lead exposure at currently acceptable levels has a small adverse effect on sperm quality, especially sperm motility, and that this effect is at least partially reversible
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    Reducing lead exposure levels partially reverses male sperm quality
star yu

Creatinine 1.7 in Chronic Kidney Disease Is It Possible to Reverse It - 0 views

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    Creatinine 1.7 in Chronic kidney disease is it possible to reverse it ? As we all know there are many factors can induce creatinine level goes high, but no matter what causes, creatinine 1.7 can be reversed with timely treatment.
Nathan Goodyear

Relationship of thyroid hormone levels and cardiov... [Endocrine. 2014] - PubMed - NCBI - 0 views

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    Patients with type II Diabetes and h/o of CVE  have higher rT3 in study.  The Endocrinologist that said reverse T3 is completely irrelevant needs to read more studies and stop listening to opinion.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

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    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

The role of dietary fat in peripheral thyroid hor... [Metabolism. 1980] - PubMed - NCBI - 0 views

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    High fat diet in this small animal study finds an increase in reverse T3 and a decrease in T3.  Higher carbohydrate diet provided no significant change.
Nathan Goodyear

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostat... - 0 views

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    animal study finds Testosterone reversed age associated sarcopenia.
Nathan Goodyear

Role of Oxidative Stress and the Microenvironment in Breast Cancer Development and Prog... - 0 views

  • oxidative stress leads to HIF-1α accumulation
  • increased levels of hydrogen peroxide in exhaled breath condensate from patients with localized breast malignancy, associated with increased clinical severity
  • Oxidative stress generated by breast cancer cells activates HIF-1α and NFκB in fibroblasts, leading to autophagy and lysosomal degradation of Cav-1
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  • Comparing mitochondrial metabolic activity revealed a difference between stroma and epithelial cells
  • metalloproteinases (MMP) such as MMP-2, MMP-3, and MMP-9 increase extracellular matrix turnover and are themselves activated by oxidative stress
  • Overexpression of NOX4 in normal breast epithelial cells results in cellular senescence, resistance to apoptosis, and tumorigenic transformation, as well as increased aggressiveness of breast cancer cells
  • Lowered expression of Cav-1 not only leads to myofibroblast conversion and inflammation but also seems to impact aerobic glycolysis, leading to secretion of high energy metabolites such as pyruvate and lactate that drive mitochondrial oxidative phosphorylation in cancer cells
  • Reverse Warburg Effect
  • secreted transforming growth factor β (TGFβ), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), fibroblast growth factor 2, and stromal-derived factor 1 (SDF1) are able to activate fibroblasts and increase cancer cell proliferation
  • oxidative stress has an important role in the initiation and preservation of breast cancer progression
  • cancer preventive role of healthy mitochondria
  • the cancer cells produce hydrogen peroxide and by driving the “Reverse Warburg Effect” initiate oxidative stress in fibroblasts. As a result of this process, fibroblasts exhibited reduced mitochondrial activity, increased glucose uptake, ROS, and metabolite production.
  • Oxidative stress results from an imbalance between unstable reactive species lacking one or more unpaired electrons (superoxide anion, hydrogen peroxide, hydroxyl radical, reactive nitrogen species) and antioxidants
  • cancer cells are able to induce drivers of oxidative stress, autophagy and mitophagy: HIF-1α and NFκB in surrounding stroma fibro-blasts
  • Studies show that loss of Cav-1 in adjacent breast cancer stroma fibroblasts can be prevented by treatment with N-acetyl cysteine, quercetin, or metformin
  • However, diets rich in antioxidants have fallen short in sufficiently preventing cancer
  • obstructing oxidative stress in the tumor microenvironment can lead to mitophagy and promote breast cancer shutdown is a promising discovery for the development of future therapeutic interventions.
  • It is widely held that HIF-1α function is dependent upon its location within the tumor microenvironment. It acts as a tumor promoter in CAFs and as a tumor suppressor in cancer cells
  • It was reported that overexpression of recombinant (SOD2) (Trimmer et al., 2011) or injection of SOD, catalase, or their pegylated counterparts can block recurrence and metastasis in mice
  • hydrogen peroxide is one of the main factors that can push fibroblasts and cancer cells into senescence
  • Recent studies show that in the breast cancer microenvironment, oxidative stress causes mitochondrial dysfunction
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    Really fascinating article on tumor signaling. The article points to a complex signaling between cancer cells and stromal fibroblasts that results in myofibroblast transformation that increases the microenvironment favorability of cancer. This article points to oxidative stress as the primary driving force.  
Nathan Goodyear

Metabolic symbiosis in cancer: refocusing the Warburg lens. - PubMed - NCBI - 0 views

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    Only abstract available here, but this article furthers the Reverse Warburg effect.  The authors here describe it as metabolic symbiosis.
Nathan Goodyear

http://www.tandfonline.com/doi/pdf/10.4161/cc.8.23.10238 - 0 views

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    Good biochemical review of the Reverse Warburg Effect.  In pdf format, so I can't highlight.
Nathan Goodyear

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skelet... - 0 views

  • short-term HFO introduces DNA methylation changes on a genome-wide scale in human skeletal muscle
  • These changes were only partly reversed after 6–8 weeks
  • The induction of DNA methylation changes after 5 days of HFO supports the growing awareness of DNA methylation as a dynamic signal that is possibly relevant to short-term day-to-day metabolic adaptations, including acute exercise
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  • Diverging DNA methylation levels between elderly, but not young, genetically identical twins indicate that environmental exposures throughout life may permanently influence DNA methylation, suggesting some preservation of de novo DNA methylation in adults
  • our finding of a slow reversibility rate indicates the demethylation process may be somewhat impeded compared with the induction of methylation changes by diet, which could have implications for the preservation or build-up of CpG methylation over time
  • A slow reversibility of DNA methylation induced by carcinogenic agents has likewise been observed due to ingestion of high-fat diets in rodents
  • the relationship between DNA methylation and gene expression is not always straightforward
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    Study finds variability of methylation and some genetic expression alteration with high fat diet.  Restated, what you eat interacts with your DNA to alter genetic expression.  This has implications on initiation of therapy as well as response to therapy.
Nathan Goodyear

Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal ... - 0 views

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    artesunate to reverse multi-drug resistance.
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN106_03%2FS000711451100033Xa... - 0 views

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    elimination of sugar, fructose in rat model found to reverse leptin resistance.
Nathan Goodyear

Lead acetate may cause erectile dysfunctio... [Cell Biol Toxicol. 2013] - PubMed - NCBI - 0 views

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    In rat model, Pb reduced NO and contributed to ED.  Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.
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Karma 8020 Wheelchair - 0 views

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    This wheelchair of choice for those who desire an extra wide, heavy-duty chair. Bariatric equipment is designed to be used in the care of large and heavy individuals. With childhood obesity levels also rising, the needs of heavier patients and those caring for them, have to be addressed. Wheelchairs that have been constructed for use by the heaviest individuals have built-in strengthening and bracing of the frame, to reduce the possibility of it twisting or buckling in use. The bariatric chairs are available in 20 and 22 inch widths with a red or blue frame. It comes with dual, reinforced steel cross braces for heavy duty support. The seat upholstery is reinforced for long life and comes with a back carry pouch for small items.The 12″ rear wheels are flat free, and the desk length arms are removable and reversible. Features bariatric chairs: Dual, reinforced steel cross braces. Supports individuals. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support. 12″ flat free rear wheels. Using a Karma KM-8020: wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Because heavy duty wheelchairs are wider than standard wheelchairs, they require wider doorways and a larger turning radius. They are also heavier to lift into a vehicle and harder to push uphill. Features Can be used as standard self propelled wheelchair or a transport chair all in one. Quick release 24″ wheels can be removed to transition self propelled chair to a transport chair. All aluminum frame. Comes with two sets of aluminum wheel locks: one for use with wheelchair, one for use with transport chair. Fold down back with deluxe back release. Comes standard with swingaway footre
star yu

Insuficiencia Renal con 42% de la Función Renal es Reversible - 0 views

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    Insuficiencia renal con 42% de la función renal es reversible ?En realidad,si hay el tratamiento adecuado y oportuno ,la función renal puede mejorar poco a poco , pero nadie puede decir si puede revertir encantamento , sin embargo si no hay nigun tratamiento ,el síntoma puede ser más complicado .
Nathan Goodyear

Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl ... - 0 views

  • These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain.
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    We are products of our genetics and our environment
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