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Nathan Goodyear

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Me... - 0 views

press.endocrine.org/...jcem.86.2.7219

low t low Testosterone Testosterone SHBG FAI free androgen index male hormone hormones aging obesity

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • NUMEROUS CROSS-SECTIONAL INVESTIGATIONS have demonstrated lower concentrations of circulating testosterone (T) and/or free T in older men
  • Two small-scale longitudinal investigations have observed decreases, with aging, in total T
  • T levels decline at a more or less constant rate, with age, in men, with no period of accelerated decline
  • ...15 more annotations...
  • aging in men is associated with decreases in bone mineral density (BMD) (18, 19), lean body and muscle mass
  • strength (22, 23) and aerobic capacity (24), as well as with increases in total and abdominal body fat, low-density lipoprotein cholesterol, and/or low-density lipoprotein/high-density lipoprotein cholesterol ratios (25, 26, 27, 28), all of which also occur in nonelderly hypogonadal men
  • Most (1, 5, 6, 7, 8, 9), but not all (10, 11, 12), cross-sectional studies have demonstrated a decrease, with age, in total T in men
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      FAI: 100 x total Testosterone nmol/L/SHBG nmol/L
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      These numbers do point to an increase in ng/dl decline in Total Testosterone with increasing age (decade group)
  • total T, but not free T index, tended to decrease with greater BMI is consistent with prior studies showing that obesity is associated with decreases in both SHBG and total T, with an unchanged T-to-SHBG ratio
  • The conventional definition for T levels is statistical (values more than 2 sd below the mean), rather than functional. Such a definition does not reflect clinical realities, such as the existence of characteristic individual set points for circulating hormone levels, below which one, but not another, individual may develop metabolic changes of hormone deficiency; nor does it address the concept of reserve capacity, the possibility that persons with hormone levels 2 sd below the population mean still may have adequate hormone concentrations to meet their metabolic needs.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      good explanation of problems with just using a number to define low T
  • both T and free T index (a calculated value related to free or bioavailable T) decreased progressively at a rate that did not vary significantly with age, from the third to the ninth decades.
  • contrasts with other studies showing diminished free, as well as total, T in with increasing total (48) or abdominal (49) obesity in men.
  • Our analysis of date-adjusted T and free T index levels, by decade, showed that relatively high numbers of older men in this generally healthy population had at least one hypogonadal value (defined as below the 2.5th percentile for young men)
  • The issue of how properly to define hypogonadism, or indeed any hormone deficiency, remains problematic
  • The decrease in free T index was somewhat steeper than that of total T, owing to a trend for an increase in SHBG with age
  • LH for gonadal function
  • It would clearly be better to define the lower limit of normal for a hormone as: the blood level at which metabolic and/or clinical sequelae of hormone deficiency begin to appear, or the level below which definite benefits can be demonstrated for hormone supplementation for a significant proportion of the population
  • an effect of aging to lower both total and bioavailable circulating T levels at a relatively constant rate, independent of obesity, illness, medications, cigarette smoking, or alcohol intake
  • Nathan Goodyear on 30 Mar 15
     
    Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.
wheelchairindia9

Pristine Flex Ostrich Mobility Wheelchair - 0 views

www.wheelchairindia.com/...ex-Ostrich-Mobility-Wheelchair

Pristine Flex Ostrich Mobility Wheelchair Ostrich Mobility Wheelchair pristine flex electric wheelchair Ostrich Wheel Chair Pristine FLEX Ostrich Pristine FLEX

shared by wheelchairindia9 on 04 Mar 16 - No Cached
  • wheelchairindia9 on 04 Mar 16
     
    Pristine Flex Ostrich Mobility Wheelchair Pristine is the most stylish powered wheelchair with revolutionary Split Frame Chassis (SFC). This indoor outdoor mobility equipment gives great comfort, stability and safety even in the toughest outdoor conditions. The body panels and the shopping basket make this equipment best suited for your kind of lifestyle. Pristine Flex Ostrich Mobility Wheelchair Features Split Frame Chassis (SFC). Call alarm, fault alarm, reverse alarm (on request). Low voltage alarm. Key pad locking. Mobility cut-off while charging. Auto shut-off after 3 minutes. Five speed selector. Length adjustable joystick control unit (can be changed from left to right and vice versa). Foldable, height adjustable and angle adjustable foot rest. Wide arm rest with height and width adjustment. Bucket seat with headrest and lap belt. Seat can be folded for transportation. Seat reclines 25 degrees in 6 steps. Removable and width adjustable calf support. Reflectors as per standards. Head lamp. Tail lamp. Pristine Flex Ostrich Mobility Wheelchair Specifications Load capacity: 110 Kg Speed: 9.5 Kmph max Speed selection: 5 speeds, Speed 1- 1.5Kmph, Speed 2-2.5 Kmph, speed 3- 4.8 Kmph, Speed 4- 7.2 Kmph, Speed 5- 9.5 Kmph Power: 320W Motor speed: 5300 rpm Gear ratio: 32:1 Brake: Electromagnetic Permissible Gradeability: 12 Degrees Drive range: 32-35 Km Ground clearance:2.5 inches Turn circle radius: 620mm Tire: Puncture free foam filled rubber tires Front- Tire diameter: 220X55 mm, Rear- Tire diameter: 320X72mm, Anti tippers-1 inch solid Battery: 24 Volt 48 Ah Sealed Maintenance Free VRLA Charger Input-230/240 Volts AC Single phase, Output-24 Volts-4 Amps DC Overall length with footrest (at 90 degree):1180mm, Overall width:640mm, Overall height: 1250mm, Overall height after folding the seat: 690mm, Overall weight: 102 Kg Seat depth: 500mm, Seat width:480mm, Backrest height: 540mm (without head rest), Backrest width: 440mm, Se
Nathan Goodyear

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate ... - 0 views

www.ncbi.nlm.nih.gov/...26589415

prostate cancer prostate cancer Testosterone SHGB men male hormones

shared by Nathan Goodyear on 09 Dec 15 - No Cached
  • Nathan Goodyear on 09 Dec 15
     
    study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer.  Included: no association with SHBG and estrogen to Testosterone ratio.
Nathan Goodyear

Revised estimates for the number of human and bacteria cells in the body | bioRxiv - 0 views

biorxiv.org/...036103

gut flora gut gut microbiome gut microbiota

shared by Nathan Goodyear on 12 Jan 16 - No Cached
  • Nathan Goodyear on 12 Jan 16
     
    Good science always challenges established dogma.  Only abstract available here.  Study calls into question the 10:1 claim: bacteria out number human cells by 10:1.  New study finds ratio more near 1:1.  
Nathan Goodyear

Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses: The Jou... - 0 views

press.endocrine.org/...jc.2015-2687

low T low Testosterone Testosterone hormones stroke ischemic stroke obesity overweight hypertension

shared by Nathan Goodyear on 18 Jan 16 - No Cached
  • Nathan Goodyear on 18 Jan 16
     
    study finds Testosterone levels <10th percentile compared to men with Testosterone levels in the 11-90th percentile were associated with increased rate of ischemic stroke (34%).  The hazard ratio was overweight/obese, and hypertension in men.  no correlation was found in women.
Nathan Goodyear

Transaminase Levels and Vigorous Exercise - 0 views

www.ncbi.nlm.nih.gov/...PMC3104191

exercise liver enzymes

shared by Nathan Goodyear on 14 Mar 18 - No Cached
  • We accept 1–2 times the upper limit of normal to be attributable to exercise
  • Some physicians, whether they are gastroenterol-ogists or internists, forget that exercise can cause this abnormality
  • it is good for patients with liver disease to exercise, particularly those with fatty liver disease
  • ...4 more annotations...
  • we see a trend toward improved ALT and AST levels in patients performing moderate exercise, regardless of the etiology of their liver disease
  • We therefore discourage very heavy exercise in these patients, but a moderate amount does not cause a problem
  • once enzymes are abnormal, they remain abnormal for up to 1 week. Were subjects to exercise vigorously again during that week, transaminase levels could increase further
  • there is a ratio that in healthy individuals is considered normal. AST levels normally measure at approximately 0.8 of ALT levels. A dysregularity of this ratio can also signal hepatic illness but usually inflammation of any kind affects both measures
  • Nathan Goodyear on 14 Mar 18
     
    Vigorous exercise yields abnormal liver enzymes.  How one defines vigorous exericse is going to vary from person to person.
Nathan Goodyear

Blood Hormones as Markers of Training Stress and Overtraining | SpringerLink - 0 views

link.springer.com/...00007256-199520040-00004

OTS overtraining syndrome hormones Testosterone cortisol

shared by Nathan Goodyear on 14 Mar 18 - No Cached
  • Nathan Goodyear on 14 Mar 18
     
    Older article, but good one still on hormones and overtraining.  Look to the Testosterone/Cortisol ratio.  OTS will lead to decreased Testosterone and increased cortisol resulting in chronic catabolic state.
Nathan Goodyear

American Journal of Obstetrics &amp; Gynecology Home Page - 0 views

www.ajog.org/...fulltext

"Vaginal mesh" immune system

shared by Nathan Goodyear on 31 Aug 18 - No Cached
  • M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
  • M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
  • an overzealous M2 response can also lead to excess tissue deposition and fibrosis
  • ...14 more annotations...
  • Studies of similar meshes that&nbsp;are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
  • the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
  • All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table&nbsp;3Table&nbsp;3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
  • Comparison of the ratio of&nbsp;the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P&nbsp;=&nbsp;.003), which indicated a shift towards a proinflammatory profile.
  • Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P &lt; .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P&nbsp;= .001), which supported an ongoing proinflammatory response.
  • the&nbsp;host response was proportional to&nbsp;the amount of material in contact with the host
  • A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
  • The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
  • Mesh-tissue complexes removed for&nbsp;mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
  • The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
  • In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
  • For hernia meshes, if the fibers are too close&nbsp;(&lt;1 mm), the fibrotic response to&nbsp;neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
  • Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
  • mesh shrinkage (50-70%) has&nbsp;been described to occur after transvaginal insertion of prolapse meshes
  • Nathan Goodyear on 31 Aug 18
     
    Mesh and the abnormal immune response.
Nathan Goodyear

Testosterone may increase rat anterior cruciate ligament strength - The Knee - 0 views

www.thekneejournal.com/...abstract

Testosterone low T low Testosterone athletes anterior cruciate ligament ACL knee knee injury sports sports injury sports medicine

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    animal study finds Testosterone likely improves ACL strength.  This study looked at castrated rats versus non-castrated rats.  The Testosterone levels were significant between the two groups.  The stress load tolerated by the ACL was different between the 2 groups. One wonders how the C:T ratio may have an impact here?
Nathan Goodyear

Levels of estradiol and testosterone are altered in Chinese men with sexual dysfunction... - 0 views

onlinelibrary.wiley.com/...abstract

male hormones' hormones estradiol Testosterone sexual dysfunction ED erectile dysfunction

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Men with sexual dysfunction found to have higher E:T ratio and higher Estradiol overall.  This was a retrospective study.
Nathan Goodyear

Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer... - 0 views

www.tandfonline.com/...1354750X.2010.491557

neutrophil to lymphocyte ratio NLR cancer

shared by Nathan Goodyear on 31 Mar 20 - No Cached
  • Nathan Goodyear on 31 Mar 20
     
    NLR <5 associated with increase in overall survival in patients with pancreatic cancer.
Nathan Goodyear

Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS - 0 views

www.ncbi.nlm.nih.gov/...PMC3893977

PCOS polycystic ovarian syndrome LH FSH SHBG Testosterone progesterone hormones bmi

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Nathan Goodyear on 13 Sep 17
     
    study of Saudi women with PCOS finds elevated LH/FSH ratio and elevated total Testosterone levels independent of age and weight; in addition, lower FSH, SHBG, and progesterone levels we found.
Nathan Goodyear

Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: pl... - 0 views

bmcmedicine.biomedcentral.com/...1741-7015-10-153

PCOS polycystic ovary syndrome glycolysis kreb's cycle TCA gluconeogenesis

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    Study found that PCOS was associated with increased glycolysis, reduced kreb's cycle activity, and decreased gluconeogenesis.  Also found a decrease in the BCAA/AAA ratio.
fitspresso

https://www.fitspresso-co.com/ - 0 views

www.fitspresso-co.com

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
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Nathan Goodyear

Frontiers | Antitumor Effects of Cannabinoids in Human Pancreatic Ductal Adenocarcinoma... - 0 views

www.frontiersin.org/...full

cannabinoids medical marijuana medical cannabis pancreatic cancer THC CBD

shared by Nathan Goodyear on 28 Nov 22 - No Cached
  • Nathan Goodyear on 28 Nov 22
     
    dose-dependent trigger of pancreatic cancer apoptosis in mouse model. They dosed up to 10 mg/kg at a ratio of THC:CBD of 1:6.
Nathan Goodyear

Seasonality, waist-to-hip ratio, an... [Psychoneuroendocrinology. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16675146

testosterone seasonal variation hormone hormones saliva salivary

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    another article discusses the seasonal variation of testosterone.  Again, testosterone levels are shown to be highest in the fall months and lowest during the summer months.  This has been found to be the case in both sexes.
Nathan Goodyear

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of pa... - 0 views

www.ncbi.nlm.nih.gov/...14719200

RA rheumatoid arthritis estrogen Testosterone inflammation

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    high estrogen to Testosterone levels in synovial fluid in those with RA.  The authors here propose that DHEA can stimulate inflammation through aromatase activity.
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