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Nathan Goodyear

Polyphenols: antioxidants and beyond - 0 views

ajcn.nutrition.org/...215S.full

polyphenols antioxidants nutrition

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Polyphenols are the most abundant antioxidants in the diet.
  • main dietary sources are fruits and plant-derived beverages such as fruit juices, tea, coffee, and red wine. Vegetables, cereals, chocolate, and dry legumes also contribute to the total polyphenol intake
  • Nathan Goodyear on 29 Sep 15
     
    polyphenols
Nathan Goodyear

Plant polyphenols as dietary antioxidants in human health and disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2835915

polyphenols antioxidants nutrition

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Polyphenols are naturally occurring compounds found largely in the fruits, vegetables, cereals and beverages
  • Polyphenols are secondary metabolites of plants
  • Nathan Goodyear on 29 Sep 15
     
    polyphenols
Nathan Goodyear

Polyphenols: food sources and bioavailability - 0 views

ajcn.nutrition.org/...727.full

polyphenols nutrition

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Fruit and beverages such as tea and red wine constitute the main sources of polyphenols
  • Nathan Goodyear on 29 Sep 15
     
    polyphenols
Nathan Goodyear

Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate foo... - 0 views

onlinelibrary.wiley.com/...abstract

polyphenols nutrition leptin insulin diet obesity

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    review article of polyphenols positive effect on neuroregulatory factors involved in food intake and energy balance.  Only abstract available here.
Nathan Goodyear

Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols - Lin -... - 0 views

onlinelibrary.wiley.com/...abstract

oolong green tea jade polyphenols weight-loss obesity overweight cholesterol hyperlipidemia breast cancer

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    oolong jade tea and other tea polyphenols shown to increase energy expenditure and provide aid in weight loss.  Also, has been shown to reduce cholesterol and inhibit breast cancer cell growth.
Nathan Goodyear

Natural polyphenols in the management of major depression, Expert Opinion on Investigat... - 0 views

informahealthcare.com/...13543784.2013.794783

polyphenols curcumin tumeric quercetin resveratrol natural depression

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Abstract only available, shows that polyphenols useful in the treatment of depression.
Nathan Goodyear

European Journal of Clinical Nutrition - Table 1 for article: Identification of the 100... - 0 views

www.nature.com/...ejcn2010221t1.html

polyphenols nutrition antioxidants

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Nathan Goodyear on 29 Sep 15
     
    top food sources for polyphenols
Nathan Goodyear

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-relate... - 0 views

www.ncbi.nlm.nih.gov/...21442412

curcumin polyphenols obesity diabetes lipids inflammation leptin resistance adiponectin

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Review article of Curcumin, a polyphenol, reduces insulin resistance, leptin resistance,  elevated glucose levels, elevated lipids, and inflammation in obesity and metabolic dysfunction.  Adiponectin levels were increased.
Nathan Goodyear

Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systema... - 0 views

care.diabetesjournals.org/...569.abstract

coffee diabetes type II diabetes type II DM polyphenol

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Coffee, whether caffeinated or decaffeinated, is found to reduce the risk of type II diabetes in meta-analysis.  According to the authors, it is the polyphenols that provide the benefits.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Resveratrol Levels and All-Cause Mortality in O... - 0 views

archinte.jamanetwork.com/article.aspx

resveratrol CVD CAD heart disease polyphenols red wine chocolate inflammation

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    New study finds no cardiovascular benefits from resveratrol.  It has long been claimed that reserveratrol is the polyphenol from red wine and chocolate that is the source of cardiovascular benefits such as found in the "french paradox".  However, this new study finds that resveratrol provides no benefit.  Studies still point to dark chocolate and red wine as means to reduce inflammation and reduce CVD risk, this study just points away from resveratrol as the source of the benefit.
Nathan Goodyear

The combined effects of exercise and foods in preventing neurological and cognitive dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3258093

diet nutrition exercise BDNF omega-3 omega 3 n-3 brain derived neurotrophic factor curcumin polyphenols neuroplasticity memory sugar saturated fats

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • The most prevalent types of cognitive impairments include disturbances in attention and learning and memory function
  • An association between BDNF and learning and memory was found when measuring the performance of rats on the Morris water maze task
  • exercise and BDNF have been associated with reducing depression and promoting cognitive enhancement.
  • ...3 more annotations...
  • In addition to reducing oxidative stress and inflammation, DHA serves to improve neuronal function by supporting synaptic membrane fluidity
  • Curcumin has also been shown to protect the hippocampus and to counteract learning impairment
  • insufficient DHA in the brain can compromise neuronal function with subsequent effects on a broad range of neurological and behavioral faculties.
  • Nathan Goodyear on 01 Nov 13
     
    diet and exercise increases BDNF.  Diets rich in omega 3, curcumin, and polyphenols increase BDNF and thus increase neuroplasticity and associated cognition.   In contrast, sugar and saturated fats in crease oxidative stress and worsened spatial learning.  This study is a review.  
Nathan Goodyear

Modulation of Wnt/β-catenin signaling pathway by bioactive food components | ... - 0 views

academic.oup.com/...2463714

cancer Wnt natural therapies natural natural therapy curcumin EGCG polyphenols Resveratrol

shared by Nathan Goodyear on 28 Mar 18 - No Cached
  • Mutations that result in Wnt/β-catenin signaling pathway being constitutively active lead to cancer
  • Nathan Goodyear on 28 Mar 18
     
    Great review of the Wnt/Beta-catenin pathway in initiation and progress of cancer.  The paper also highlights the common naturally occuring therapies to block this pathway: Flavonoids, curcumin, EGCG, green tea polyphenols, resveratrol, retinoids, lycopenes, lupeol, isothiocyanates.
Nathan Goodyear

Efficacy of liposomal curcumin in a human pan... [Anticancer Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24023285

curcumin tumeric pancreatic cancer

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    liposomal curcumin at 20 mg/kg reduced pancreatic tumor growth by 42% in in vitro and xenograft studies.  The curcumin, the most prevalent polyphenol in tumeric, was given intraperitoneal in this study.
Nathan Goodyear

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57... - 0 views

jn.nutrition.org/...919.abstract

curcumin adipogenesis obesity weight loss

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • Dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism
  • curcumin, the major polyphenol in turmeric spice
  • curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain
  • ...1 more annotation...
  • Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity
  • Nathan Goodyear on 28 Apr 11
     
    Curcumin useful in obesity
Nathan Goodyear

The emerging role of nutrition in Parkinson's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3945400

nutrition disease Parkinson's disease Parkinson's

shared by Nathan Goodyear on 18 Oct 17 - No Cached
  • Nathan Goodyear on 18 Oct 17
     
    Good review of the current data on the role of nutrition in Parkinson's disease.  Take home, a lot of data is conflicting.  But the figure at the end does well to summarize: diet rich in polyphenols in fruits/veggies, carotenoids, resveratrol, Vitamin C, D, E, and MUFA and PUFA are neuroprotective compared to dairy being neurodegenerative.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

mitochondria oxidative stress heart failure heart

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
      Nathan Goodyear on 19 Mar 13
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
  • Nathan Goodyear on 19 Mar 13
     
    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast ... - 0 views

toxsci.oxfordjournals.org/...71.full

resveratrol wine red wine aromatase inhibitor inhibition cancer

shared by Nathan Goodyear on 18 Dec 12 - No Cached
  • Nathan Goodyear on 18 Dec 12
     
    resveratrol in red wine is an aromatase inhibitor.
Nathan Goodyear

Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglycerid... - 0 views

www.ncbi.nlm.nih.gov/...20222050

curcumin polyphenols leptin obesity leptin resistance insulin insulin resistance fructose diet

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    curcumin found to reduce leptin resistance and insulin resistance in fructose-induced hypertriglyceridiemia in rat model.
Nathan Goodyear

Overview of antibacterial, antitoxin, anti... [Mol Nutr Food Res. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17195249

green tea EGCG flavanoids polyphenols flu influenza anti-viral cold viral virus

shared by Nathan Goodyear on 22 Nov 11 - No Cached
  • Nathan Goodyear on 22 Nov 11
     
    green tea flavanoids shown to have antiviral properties
Nathan Goodyear

Journal of Investigative Dermatology - Abstract of article: Green Tea Polyphenol Epigal... - 0 views

www.nature.com/...jid2008103a.html

EGCG keloid green tea epigallocatechin-3-gallate

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG suppressed collagen production in keloid formation in this study.
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