In general, the effects of exposure
to organic mercury are primarily neurologic,
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shared by Nathan Goodyear on 06 Sep 11
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Biological monitoring survey of orga... [Environ Health Perspect. 2001] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...11333193
children pediatrics organic organophosphates pesticides toxins envirnomental
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shared by freshbombsusa on 07 May 20
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Reason to Use CBD Skincare CBD Products - 0 views
freshbombsusa.livejournal.com/3200.html
cbd products cbd beauty products cbd skincare products organic beauty products cbd oil cbd facial oil cbd night cream cbd eye cream
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Why should you add CBD face products to your daily skincare routine? Cannabidiol-infused products possess anti-inflammatory properties that are effective in treating different types of skin conditions. To know the reason for adopting organic CBD skincare read our blog. Visit our website to buy CBD organic beauty products.
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Dehydroepiandrosterone in the treatment of erectile... [Urol Res. 2001] - PubMed - NCBI - 0 views
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Adipose Tissue as an Endocrine Organ - 0 views
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shared by Nathan Goodyear on 29 Apr 15
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PLOS ONE: Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular ... - 0 views
journals.plos.org/...article
hormone hormones low T low Testosterone hypogonadism Testosterone probiotic L reuters probiotics Lactobacillus lactobacillus reuteri male aging
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Studies in both humans and rodents, however, suggest that low testosterone is due to age-related lesions in testes rather than irregular luteinizing hormone metabolism
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Various dietary factors and diet-induced obesity have been shown to increase the risk for late onset male hypogonadism and low testosterone production in both humans and mice
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Testosterone deficiency and metabolic diseases such as obesity appear to inter-digitate in complex cause-and-effect relationships
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dietary supplementation of aged mice with the probiotic bacterium Lactobacillus reuteri makes them appear to be younger than their matched untreated sibling mice
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These results indicate that gut microbiota induce modulation of local gastrointestinal immunity resulting in systemic effects on the immune system which activate metabolic pathways that restore tissue homeostasis and overall health
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all these studies we consistently observed that young and aged mice consuming purified L. reuteri organisms had particularly large testes and a dominant male behavior.
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The testes of probiotic-fed aged mice were rescued from both seminiferous tubule atrophy and interstitial Leydig cell area reduction typical of the normal aging process. Preservation of testicular architecture despite advanced age or high-fat diet coincided with remarkably high levels of circulating testosterone. The beneficial effects of probiotic consumption were recapitulated by the depletion of the pro-inflammatory cytokine Il-17.
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feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight
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mice with dietary L. reuteri supplements were rescued from diet-induced obesity and had normal body weight and lean physique
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Despite the comparable numbers of ST profiles, we determined that testes from L. reuteri-treated mice had increased ST cross-sectioned profiles
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the probiotic organism induced prominent Leydig cell accumulations in the interstitial tissue between the ST's
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The probiotic-associated increase of interstitial Leydig cell areas was sustained with advancing age at 7 (CD vs CD+LR, P = 0.0025; CD+E.coli vs CD+LR, P = 0.0251) and 12 months
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mice eating L. reuteri had profoundly increased levels of circulating testosterone regardless of the type of diet they consumed
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previous studies we found that dietary probiotics counteract obesity [19] and age-related integumentary pathology [18] at least in part by down-regulating systemic pro-inflammatory IL-17A-dependent signaling
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blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics
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L. reuteri-associated prevention of age- and diet-related testicular atrophy correlates with increased numbers and size of Leydig cells
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Lactobacillus reuteri we discovered that aging male animals had larger testes compared to their age-matched controls
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xamined testes of probiotic microbe-fed mice and found that they had less testicular atrophy coinciding with higher levels of circulating testosterone compared to their age-matched controls
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Similar testicular health benefits were produced using systemic depletion of the pro-inflammatory cytokine Il-17 alone, implicating a chronic inflammatory pathway in hypogonadism
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One specific aspect of this paradigm is reciprocal activities of pro-inflammatory Th-17 and anti-inflammatory Treg cells
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Feeding of L. reuteri organisms was previously shown to up-regulate IL-10 levels and reduce levels of IL-17 [19] serving to lower systemic inflammation
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insufficient levels of IL-10 may increase the risk for autoimmunity, obesity, and other inflammatory disease syndromes
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Westernized diets are also low in vitamin D, a nutrient that when present normally works together with IL-10 to protect against inflammatory disorders
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The hormone testosterone has been shown to act directly through androgen receptors on CD4+ cells to increase IL-10 expression
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studies in both humans and rodents suggest that hypogonadism is due to age-related lesions in testes rather than irregular LH metabolism
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We postulate that probiotic gut microbes function symbiotically with their mammalian hosts to impart immune homeostasis to maintain systemic and testicular health [34]–[35] despite suboptimal dietary conditions.
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Dietary factors and diet-induced obesity were previously shown to increase risk for age-associated male hypogonadism, reduced spermatogenesis, and low testosterone production in both humans and mice [2]–[4], [8]–[11], [14]–[17], phenotypic features that in this study were inhibited by oral probiotic therapy absent milk sugars, extra protein, or vitamin D supplied in yogurt.
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Similar beneficial effects of probiotic microbes on testosterone levels and sperm indices were reported in male mice that had been simultaneously supplemented with selenium
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Testes histomorphometry and serum androgen concentration data were both suggestive of a probiotic-associated up-regulation of spermatogenesis in mice
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the initial changes of testicular atrophy begin to occur in mice from the age of 6 moths onwards [7] and indicates that the trophic effect of L. reuteri on Leydig cells is a key event which precedes and prevents age-related changes in the testes of mice. This effect is reminiscent of earlier studies describing Leydig cell hyperplasia and/or hypertrophy in the mouse and the rat testis that were achievable by the administration of gonadotropins, including human chorionic gonadotropin, FSH and LH
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Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views
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Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
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No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
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a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
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Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
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Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
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Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
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Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
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Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
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Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis. Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L. The IV groups maintained elevated serum C levels for up to 96 hours post infusion.
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shared by Nathan Goodyear on 31 May 12
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Adipose Tissue: The New Endocrine Organ? - 0 views
www.springerlink.com/...fulltext.pdf
fat obesity adipocytokines cytokines adipocytes overweight inflammation inflammatory adipokines chemokines
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shared by Nathan Goodyear on 17 Feb 14
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http://www.epa.gov/teach/chem_summ/mercury_org_summary.pdf - 0 views
www.epa.gov/...mercury_org_summary.pdf
Mercury Organic methyl ethyl methylMercury Hg ethylMercury EPA heavy metals toxicity
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POISONING BY METHYL MERCURY COMPOUNDS - 0 views
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Annals of Occupational and Environmental Medicine | Full text | The Relationship of Liv... - 0 views
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shared by wheelchairindia9 on 31 Mar 16
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Tynor Rib Belt - 0 views
www.wheelchairindia.com/...Tynor-Rib-Belt
How to Effectively use a Rib Belt most common injuries to the chest rib cage is a protective organ flat chest bone called the sternum toning up abdominal muscles after surgery reduction of waist size compression belt to support
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Tynor Rib Belt Rib belt is applied to the thoracic and upper abdominal region to compress and bind the rib cage during rib fractures and postoperative care, while allowing sufficient flexibility for comfortable breathing. Extra porous. With splinting pad. No buckling or rolling over. Controlled compression. Tynor Rib Belt Features Light weight and thin construction, does not peep through the clothes improves patient compliance. Extra porous webbing improves ventilation and comfort of the patient. Broad hook and loop tape panel offers better holding and size adjust ability. Optimal compression, tones up abdominal muscles following surgery, CS or delivery. Special nylon reeves prevent rolling over of belt. Tynor Rib Belt Measurements Measure circumference around the chest.
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Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through t... - 0 views
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Tech-Enabled Contract Research Organization | Vial CRO - 1 views
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Measurement of salivary cortisol in 2012 - laboratory techniques and clinical indications - 0 views
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Review of data analyzing salivary cortisol finds saliva is a great medium, with sensitivity and specificity exceeding 90%, for evaluating the stress response. So, where is the Louisiana State Board of Medicine, BCBS, and other insurance companies on this. They are in favor of inferior testing and treatments ie. hysterectomies for pelvic pain (50% success rate). The great item here is this is not one study but an analysis of multiple studies. This is contrast to "opinions" that often govern the above mentioned organizations/businesses.
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Metabolic management of brain cancer - 0 views
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Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
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the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
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Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
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most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
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We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
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complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
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As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
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New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
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The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
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Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
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Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
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Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
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Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
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the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
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The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
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We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
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In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
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mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
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targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
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The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
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Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
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TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
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Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
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DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
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We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
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Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
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More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
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The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
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targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
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Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
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shared by Nathan Goodyear on 18 May 16
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Telomerase at the intersection of cancer and aging - 0 views
www.ncbi.nlm.nih.gov/...PMC3896987
telomere telomeres telomerase telomerase activator aging disease cancer
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The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
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increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
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In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
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Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
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the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
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telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
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Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
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recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
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Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
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telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
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These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
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a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
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Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging. In contrast, telomerase activity is found to be involved in carcinogenesis. Increased carcinogenic potential of telomerase activity has not borne out in studies. In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
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Top skincare tips for working women - 0 views
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Working Women Skincare Tips If you are able to run away from fast food fast sufficient, you might be doing a enormous favour to your skin. The ingredients in fast food can damage your health and your skin too. At work, have a some of almonds, berries or some fruits handy. You need habitually eat all types and colours of organic, fresh vegetables, particularly green and leafy ones. Be necessary at least one cup of two-three dissimilar types of berries thrice a week. Take in veggie juices in your diet. These types of foods are sure to improvement your antioxidant
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shared by Nathan Goodyear on 29 Sep 16
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http://www.cell.com/trends/endocrinology-metabolism/pdf/S1043-2760(00)00301-5.pdf - 0 views
www.cell.com/...S1043-2760(00)00301-5.pdf
fat adipose tissue aromatase cortisol leptin hormones obesity
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