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Nathan Goodyear

Abstract 21277: Homocysteine and Cardiovascular Risk in Low Risk Healthy Adults - An An... - 0 views

circ.ahajournals.org/...A21277

homocysteine cardiovascular CAD disease

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Homocysteine significantlyimproves risk prediction of cardiovascular events in healthyadults
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine found to be helpful in predicting cardiovascular events in healthy adults
Nathan Goodyear

Vitamin D and all-cause mortality among adults in USA: findings from the National Healt... - 0 views

ije.oxfordjournals.org/...998.abstract

vitamin vitamin d mortality nutrition health

shared by Nathan Goodyear on 10 Sep 11 - No Cached
  • Nathan Goodyear on 10 Sep 11
     
    low Vitamin D inversely related to mortality rates
Nathan Goodyear

Homeopathy service in a National Health Service community menopause clinic: audit of cl... - 0 views

mi.rsmjournals.com/...72.abstract

homeopathy health menopause

shared by Nathan Goodyear on 21 Sep 11 - No Cached
  • Nathan Goodyear on 21 Sep 11
     
    study shows that homeopathy improves 81.4% of menopause symptoms
Nathan Goodyear

Obese Americans now outweigh the merely overweight | Reuters - 0 views

www.reuters.com/...sity-usa-idUSTRE50863H20090109

obese overweight americans statistics obesity weight loss

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • Numbers posted by the National Center for Health Statistics show that more than 34 percent of Americans are obese, compared to 32.7 percent who are overweight. It said just under 6 percent are "extremely" obese.
  • More than one-third of adults, or over 72 million people, were obese in 2005-2006, the NCHS said in its report
  • In May, the CDC reported that 32 percent of U.S. children fit the definition of being overweight, 16 percent were obese and 11 percent were extremely obese.
  • Nathan Goodyear on 15 Apr 11
     
    obesity in America
Nathan Goodyear

Salivary sex hormone measurement in a national, po... [J Gerontol B Psychol Sci Soc Sci... - 0 views

www.ncbi.nlm.nih.gov/...19204073

saliva salivary estradiol progesterone DHEA testosterone hormone hormones

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • These data demonstrate a high cooperation rate with in-home salivary specimen collection from older adults and good validity of sex hormone measurements
  • Nathan Goodyear on 13 Jul 11
     
    salivary estradiol, progesterone, DHEA, and testosterone validated in study of 3,005 men and women
Nathan Goodyear

Effectiveness of computer-aided detection... [J Natl Cancer Inst. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/pubmed

computer-aided detection CAD breast cancer prevention

shared by Nathan Goodyear on 17 Oct 11 - No Cached
  • Nathan Goodyear on 17 Oct 11
     
    computer-aided detection in mammograms shown to not improve the detection rate or the prognosis of breast cancer
Nathan Goodyear

PLOS ONE: Are Baby Boomers Healthier than Generation X? A Profile of Australia's Workin... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0093087

obesity overweight baby boomers generation X health

shared by Nathan Goodyear on 27 Mar 14 - No Cached
  • Nathan Goodyear on 27 Mar 14
     
    Generation X more obese than baby boomers.  There was no difference in physical activity levels.  This points only to environment i.e. diet, environmental toxins...
Nathan Goodyear

Deiodinases - National Academy of HypothyroidismNational Academy of Hypothyroidism - 0 views

www.nahypothyroidism.org/deiodinases

Thyroid hormone hormones physiology T4 T3 rT3 reverse T3 metabolites deiodinase

shared by Nathan Goodyear on 23 Nov 14 - No Cached
  • Nathan Goodyear on 23 Nov 14
     
    Great review of thyroid metabolism.
Nathan Goodyear

National Institutes of Health Pathways to Prevention Workshop: The Role of Opioids in t... - 0 views

annals.org/article.aspx

NIH opioids chronic pain pain health

shared by Nathan Goodyear on 16 Jan 15 - No Cached
  • Nathan Goodyear on 16 Jan 15
     
    NIH panel review finds little empirical evidence to support the use of opioids in chronic pain.
Shelia Morales

Skincare Maryville | Belleville | National Makeup Artist Event - 0 views

www.kristenjacobs.com/specialevents

Skincare St. louis Skincare Edwardsville Skincare Maryville Skincare Fairview heights Skincare Belleville Skincare Swansea Skincare Shiloh Skincare O'fallon

shared by Shelia Morales on 10 Feb 15 - No Cached
  • Shelia Morales on 10 Feb 15
     
    Invites you and a friend to special Hands on Tutorial demonstrating how to achieve a flawless look as a recognized industry leader, Michael is highly sought after and offers limited engagements.
Nathan Goodyear

Sex Hormone-Binding Globulin and the Free Androgen Index Are Related to Cardiovascular ... - 0 views

circ.ahajournals.org/...1242.full

CVD cardiovascular disease SHBG free androgen index hormone hormones women perimenopause

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    The opposite effect strikes again: elevated free androgen index is associated with CV risk in perimenopause women across 5 ethnic groups.  Low SHBG was associated with increased CVD.
Nathan Goodyear

Erectile Dysfunction and Mortality in a National Prospective Cohort Study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26559652

ED erectile dysfunction men CVD cardiovascular death mortality

shared by Nathan Goodyear on 06 Jan 16 - No Cached
  • Nathan Goodyear on 06 Jan 16
     
    ED equals CVD in men.  This cohort found a 70% increase in early mortality in men with ED.
Nathan Goodyear

Evidence of estrogenic endocrine disruption in smallmouth and largemouth bass inhabitin... - 0 views

www.sciencedirect.com/...S0147651315301093

low T low Testosterone hormones environment EDC endocrine disruptor endocrine disruptors fish estrogen

shared by Nathan Goodyear on 05 Jan 16 - No Cached
  • Nathan Goodyear on 05 Jan 16
     
    Is our effect on the environment and the environments, in turn, effect on us politics or science?  It is science that is manipulated by politicians for political gain/power.  In this study of male small/large mouth bass in NE America are found to have significant female characteristics  i.e. eggs where testes should exist...where none should exist.  The numbers were as high as 85% in the small mouth base compared to 27% for the large mouth bass.  Is there any wonder we have a low T epidemic in men?  The most likely cause are endocrine disruptors.  It is a concern that the authors did not look for endocrine disruptors in the water at the time of this study of the fish.
annebronte

Environmental Issues in Pakistan : News 313 | Pakistan Latest News | - 1 views

news313.pk/...vironmental-issues-in-pakistan

envirnoment issues

shared by annebronte on 09 Aug 18 - No Cached
  • annebronte on 09 Aug 18
     
    Usually and mostly we know about three types of pollutions; air pollution, water pollution, and noise pollution. These changes to the planet have already caused much of the disastrous conditions for the future. So, in this article, we will discuss Environmental Issues in Pakistan.
Nathan Goodyear

Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colo... - 0 views

academic.oup.com/...5038128

insulin diet nutrition cancer colon cancer

shared by Nathan Goodyear on 26 Jun 18 - No Cached
  • Nathan Goodyear on 26 Jun 18
     
    New prospective study of 1023 patients finds that high-insulogenic diet, also know as a traditional American diet, high glycemic, high sugar diet... is associated with an increased risk of cancer recurrence and mortality compared to low insulogenic diet.  The authors concluded that this would be beneficial for after surgical resection in people with stage III colon cancer. My question, is why wait on the development of cancer: use a low-insulogenic diet to prevent the cancer all together or when diagnosed implement immediately.  Why wait? Treat early! Prevent!
Nathan Goodyear

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epitheli... - 0 views

www.pnas.org/E7301

Ivermectin cancer ovarian cancer oncogene oncogenes

shared by Nathan Goodyear on 20 Mar 18 - No Cached
  • we functionally validated a potent EOC oncogene, KPNB1, and showed its clinical relevance to human EOC
  • a well-established antiparasitic drug, ivermectin, has antitumor effects on EOC through its inhibition of KPNB1
  • EOC has high intertumor and intratumor heterogeneity at the molecular and epigenetic levels
  • ...22 more annotations...
  • the mortality rate of EOC has not been significantly changed for several decades
  • Sequencing revealed that almost all tumors (96%) had mutations in TP53, which serves as a major driver of this cancer
  • Low-prevalence but statistically significant mutations in nine other genes including NF1, BRCA1, BRCA2, RB1, and CDK12 were also identified, but the majority of genes were mutated at low frequency, making it difficult to distinguish between driver and passenger mutations
  • KPNB1 inhibition via any of three KPNB1 siRNAs or importazole treatment induced apoptosis in human EOC cell lines (Fig. 3 A–F and Fig. S4), and was accompanied by an increase in the expression levels of the proapoptotic proteins BAX and cleaved caspase-3
  • Stable overexpression of KPNB1 in SKOV3 and OVCAR3 (Fig. S6) significantly accelerated cell proliferation/survival (Fig. 5 A–C), confirming that KPNB1 functions as an oncogene in EOC
  • KPNB1 overexpression significantly decreased caspase-3/7 activity (Fig. 5D), in addition to the expression levels of cleaved caspase-3 and BAX proteins (Fig. 5E). KPNB1 overexpression also decreased p21 and p27 protein levels (Fig. 5E), as opposed to their increase by KPNB1 inhibition
  • KPNB1 functions as an antiapoptotic and proproliferative oncogene in EOC.
  • Patients with higher expression levels of KPNB1 showed earlier recurrence and worse prognosis than those with lower expression levels of KPNB1
  • KPNB1 acts as an oncogene in human EOC and represents a promising therapeutic target.
  • ivermectin treatment suppressed cell proliferation/viability in a dose-dependent manner (Fig. 7A), indicating that it exerts an antitumor effect on EOC
  • ivermectin also induced apoptosis
  • ivermectin increased the expression levels of BAX, and cleaved PARP, as well as p21 and p27
  • KPNB1 inhibition is responsible for the antitumor effect of ivermectin
  • we found that ivermectin synergistically reduced cell proliferation/viability in combination with paclitaxel in human EOC cells
  • Single treatment of ivermectin or paclitaxel reduced tumor growth in nude mice, but, notably, combination treatment of ivermectin and paclitaxel almost completely suppressed tumor growth
  • ERBB2, is amplified and overexpressed in many cancers, including breast (31), ovary (31), colon (32), bladder (33), non-small-cell lung (34), and gastric cancer (35), and is a poor prognostic factor in certain cancer types
  • KPNB1 was the second-highest-ranked gene identified in our screen
  • Increased KPNB1 protein levels have been reported in several cancers, including cervical cancer (42), hepatocellular carcinoma (43), and glioma (44), suggesting KPNB1’s oncogenic potential in these tumor types
  • our findings suggest that KPNB1 might serve as a master regulator of cell cycle by regulating several cell cycle-related proteins, including p21, p27, and APC/C family members
  • higher and/or more-frequent doses of ivermectin than currently approved for humans are well tolerated in humans
  • none of the mice in this study treated with the effective dosage of ivermectin for in vivo anticancer therapy showed severe adverse event
  • we found that the combination of ivermectin and paclitaxel produces a stronger antitumor effect on EOC cell lines than either drug alone
  • Nathan Goodyear on 20 Mar 18
     
    Ivermectin found to be pro-apoptotic for the epithelial ovarian cancer oncogene, KPNB1 in in Vivo study.  This effective anti-parasitic drug inhibits the KPNB1 oncogene.
Nathan Goodyear

PET/CT Standardized Uptake Values (SUVs) in Clinical Practice and Assessing Response to... - 0 views

www.ncbi.nlm.nih.gov/...PMC3026294

cancer PET scan PET_CT CT PET_CT scan

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • use of PET in clinical research, clinical trials, and drug discovery
  • use of PET/CT in assessing response to therapy
  • In some cases, such as Hodgkins lymphoma, quantitative PET/CT imaging may not actually be needed, as success can be defined by the complete absence of tracer uptake in the PET image following a course of standardized therapy
  • ...9 more annotations...
  • The utilization of PET/CT to assess response to therapy is increasing in the US related, in part, to the creation and subsequent favorable results of the National Oncologic PET Registry (NOPR)
  • Changes in size as a result of therapy may take many months to develop and any opportunity to make early decisions about therapy success or failure is often unduly delayed or lost altogether
  • measures of changes in metabolic activity via FDG PET/CT can provide an alternate approach to assess response to therapy -- often very early in the course of treatment
  • Current recommendations are that tumor SUVs should be reported
  • The true tracer uptake in a patient is composed of two components: the first being the amount of tracer uptake (e.g. FDG) associated with the disease status (the signal of interest), which can be modified by the biophysiological status of the patient. One of the more important patient parameters is the blood glucose level, which has been shown to inversely-linearly affect SUVs
  • A prospective study by Crippa et al.30 in eight patients showed that as blood glucose levels were increased from 92.4 ±10.2 to 158 ± 13.8 mg/100 ml by glucose loading, the average SUV of 20 liver metastases decreased from 9.4 ± 5.7 to 4.3 ± 8.3
  • chemotherapy can result in impaired renal function, significantly reducing the clearance of plasma FDG through the kidney and thus increasing tumor SUV relative to an initial PET scan
  • The second component of the true tracer uptake is biological variability
  • The biological variability has been estimated in several test-retest studies7,32–35 at approximately 10% for scans repeated within a few days
  • Nathan Goodyear on 20 Feb 18
     
    Good review of the SUVs of a PET/CT scan.
Nathan Goodyear

Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systemati... - 0 views

www.ncbi.nlm.nih.gov/...PMH0027131

low T low Testosterone Testosterone testosterone therapy cancer prostate cancer male hormones

shared by Nathan Goodyear on 01 Oct 16 - No Cached
  • Nathan Goodyear on 01 Oct 16
     
    meta-analysis finds no evidence of testosterone therapy and increased risk of prostate cancer.
Nathan Goodyear

Cancer Drugs - National Cancer Institute - 0 views

www.cancer.gov/...drugs

cancer chemotherapy cancer drugs

shared by Nathan Goodyear on 09 May 18 - No Cached
  • Nathan Goodyear on 09 May 18
     
    NIH resource of cancer drugs
Nathan Goodyear

Immunotherapy targets metastatic breast cancer-cell mutations - National Cancer Institute - 0 views

www.cancer.gov/...gets-breast-cancer-case-report

immunotherapy cancer tumor-infiltrating lymphocytes TILs

shared by Nathan Goodyear on 08 Jun 18 - No Cached
  • Nathan Goodyear on 08 Jun 18
     
    This is simply a press release from the NCI, but it highlights the move to immunotherapy as the future of cancer therapy.
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