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Testosterone therapy post brachytherapy radiation found to have no recurrence and/or documented cancer progression in follow up out to 9 years.  Not all the men included in this study had none detectable psa levels.  PSA levels were all less than 1 ng/ml; 74.2% were none detectable, but 22% were detectable up to 0.5 ng/ml.  One of the patients had a transient rise in psa, but no recurrence or cancer progression was noted, and therapy was continued.

computer-aided detection in mammograms shown to not improve the detection rate or the prognosis of breast cancer

Britain's biotech firm Avacta Group on Monday (January 10) announced halting sales of its Covid-19 rapid antigen lateral flow test AffiDX to replace antibodies in the device and increase its ability to diagnose the Omicron variant. The company stated that AffiDX is capable of detecting Omicron when the virus is present in high numbers in samples, but the sensitivity of the test reduces at lower viral loads. The performance of all rapid antigen tests came under scanner in wake of a large number of mutations in the Omicron variant. AffiDX contains both a proprietary Affimer reagent and a commercially available antibody. The Affimer reagent detects the Omicron variant with the same sensitivity as the Delta variant, and performance of the antibody is paired with the Affimer reagent in the test. This has been affected by the additional Omicron mutations, the firm said. Alastair Smith, chief executive of Avacta Group, said: "Our determination to only provide high quality, high performance diagnostic tests has led us to the correct decision to pause all marketing of the AffiDX® lateral flow antigen test. We have, of course, been unable to market the product in the UK since October 2021, as the product continues to await approval under the new CTDA regulatory process.

This article reveals how data is massaged to promote a viewpoint. In this case mammograms.  Don't let your passions get the best of you, objectively review the data.  Scientists are not doing that these days. Mammograms do help and are needed in the screening, however, mammograms do cause harm and help to promote the same disease it seeks to detect early.  This is in some cases. Also, remember, mammograms are early detection, not prevention.

computer-aided mammography results in increased biopsy rate, yet no improvement in invasive breast cancer detection seen.

Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children.  These levels are very low in pre-pubertal children and makes detection by ELIZA difficult.  This proposed mechanism improves hormone detection.

saliva testing used in early disease detection

Iron and Copper accumulation in blood vessel wall may play role in diesease progression

This study shows that "healthy marathon" runners may not be as healthy as once thought.  Basically, current strategies to assess coronary artery calcification is inadequate.  Point: damage is being done that is not being detected.

Small study looking at testosterone in men with ED.  They found "serum total testosterone level is not a sensitivity indicator for detection of hypogonadism".  Salivary free testosterone levels is the best way to evaluate androgen levels.

this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.

this study found no increase in inflammatory cytokines in those men on androgen deprivation therapy for prostate cancer.  The question, is they evaluated testosterone in the serum, so did they really see a decrease in androgens or just a decrease in the transport of androgens.  Saliva would have detected a true androgen deficient state.

night-time cortisol via LC shown to reliable in detection of Cushing Syndrome

This study looked at combined sex hormone analysis via gas chromatography-mass spec.  Levels were able to be detected as low as 0.002 mcro/L in saliva.  This study validates the GC-MS for the use of multiple, simultaneous steroid hormone analysis

Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.

Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...

Glyophosate found to be increased in the urine of animals and humans eating GMO food products.  Interesting association that "ill" humans had higher urinary glyophosate levels.  What is defined as "ill" is left to be determined. But clearly, glyophosate is not the innocent product that we have told it was.

salivary testosterone proven statistically reliable method to detect changes in the biologically active hormone.

Eye exams are important for patients of all ages to get regular eye exams whether they are having problems or not. Eye exams can detect a problem before you even know you have one. This is particularly important if you have a family history of eye problems.

Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.