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Nathan Goodyear

Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treat... - 0 views

  • Experimental animal studies have shown that Borrelia burgdorferi, the agent of Lyme borreliosis, consistently establishes persistent infections in a variety of immunocompetent hosts, including laboratory mice [1], white-footed mice (Peromyscus leucopus) [2], [3], [4], rats [5], hamsters [6], guinea pigs [7], gerbils [8], dogs [9], and nonhuman primates, including rhesus macaques (Macaca mulatta) [10] and baboons (Papio spp.
  • With the advent of PCR, and more recently real-time quantitative PCR (qPCR), which offers greater sensitivity and specificity, B. burgdorferi-specific DNA has been found to persist for months following antibiotic treatment in tissues of experimentally infected mice [14], [15], [16], [17], [18], [19], [20], dogs [9], [21] and macaques [22], as well as humans
  • In addition, intact spirochetes have been demonstrated by immunohistochemistry in connective tissue of culture-negative treated mice and within ticks that fed upon them [15], [17] as well as in tissues of and ticks that fed upon treated macaques
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  • Results of this study demonstrated not only persistence, but also resurgence of non-cultivable B. burgdorferi in tissues of mice at up to 12 months following antibiotic treatment
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    mouse model using ceftriaxone treatment regimen found that non-cultivatable B. burgdorferia persisted 8+ months post treatment and there was an increase in B. burgdorferi DNA in multiple sites at 12 months.
Rejuvenate Hair Transplant

Best FUT Hair Transplant in India - 0 views

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    FUT means Follicle Unit Extraction. This is a technique of hair transplant. In this, a linear cut is given on the back side of the head to harvest a strip having multiple follicles. This technique is a very good technique but slowly in India, its use is decreasing because it needs a big trained team of assistants and more experience of the surgeon. The FUT is mainly done by plastic surgeons.
Nathan Goodyear

Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells - 1 views

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    Cell study finds that amygdalin inhibits cell proliferation and induces cytotoxicity in multiple breast cancer cell lines, including TNBC.
pharmacybiz

PDA expresses concerns as Boots decides to cut opening hours at some pharmacies - Lates... - 0 views

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    The Pharmacists' Defence Association (PDA) has expressed concerns over Boots UK's decision to reduce supplemental opening hours at some pharmacies. The association stated: "Some pharmacists and other staff at Boots are being notified this week of changes to opening hours at their place of work, with local briefings taking place. The PDA are supporting their members to deal with any potential impact on their employment." It said that reducing pharmacy opening hours would affect patients' access to a trusted healthcare professional, especially if it is being done by the largest community pharmacy multiple. It even called upon the NHS to adequately fund community pharmacies to ensure they remain open when patients and local communities need their services. Meanwhile, Boots management has informed PDA that most of its employees are not pharmacists, and "less pharmacists are expected to be directly impacted by these changes than other colleagues," PDA said.
spineneuro

Muntassir Khan from Saudi Arabia Receives Extensive Rehab in India ~ Medical Tourism M... - 0 views

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    After looking through multiple hospitals Abida decided to get her uncle treated by Dr. Vipul Gupta India. After a week of going through the entire process of obtaining the Visa and making the necessary travel arrangements, Muntassir and his niece arrived in India on the 6th of August.
pharmacybiz

Lateral Flow Tests Shortages Bear Customers Wrath - 0 views

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    Increased demand and shortages of lateral flow tests are pushing staff at pharmacies to bear the brunt from frustrated customers who are unable to get their free lateral flow tests, Daily Mail reported. Some Britons claimed that they have been unable to get lateral flow tests at their local pharmacies for up to a fortnight while some pharmacies were forced to put up sign warning stating they have run out of free tests. Given the patchy supply of test kits, pharmacy bosses warned that staff are facing 'unfair' and 'abusive' behaviour by customers, the newspaper reported.Dr Leyla Hannbeck, chief executive of the Association of Independent Multiple Pharmacies (AIMP), told the newspaper: "Up until yesterday the supply to pharmacies was still patchy. The past few days the situation has not improved. "Pharmacies are having to put up with a lot of abuse and aggressive behaviours by members of the public because of this situation which is unfair. "The demand is still very high now because the governments guidelines put a lot of emphasis on testing as a key out of self isolation, so naturally as Omicron cases are high people are reliant on tests to get on with daily life."
Nathan Goodyear

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-co... - 0 views

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    effect of time and temperature on the viability of melanoma cell lines and expression of HSP 70 & 90 after brief exposure to hyperthermia. While hyperthermia has multiple mechanisms of action, this paper elucidates two essential benefits of high-dose hyperthermia. First, the study illustrates why high-dose hyperthermia treatments (45°C - 47°C) are so much more effective than the low-dose hyperthermia (39°C - 43°C) produced by commercially available heating devices.
Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
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  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
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    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

Access : Neuroimmunology: Estrogen receptor ligands suppress inflammatory responses in ... - 0 views

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    Granted, this study was in an animal model of MS, but signaling through ER-beta was shown to decrease inflammation from astrocytes and microglial cells in the brain.  These immune cells are known to play prominent roles in excitotoxic diseases such as MS.  So, again, it is not just about the message, but also about how the message is interpreted.
Nathan Goodyear

PLOS Medicine: Causal Relationship between Obesity and Vitamin D Status: Bi-Directional... - 0 views

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    increasing BMI associated with decreasing vitamin D levels
Nathan Goodyear

PLOS Medicine: Causal Relationship between Obesity and Vitamin D Status: Bi-Directional... - 0 views

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    Study finds that obesity is linked to lower vitamin D.  Not that there is merely an association, but that the elevated BMI is the cause of lower vitamin D levels.
Nathan Goodyear

Transrepression of Inflammation -- Foley 4 (173): ec141 -- Science Signaling - 0 views

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    ER-beta agonist activity/agnoists inhibit inflammatory gene expression in microglia and astrocyte cells.
Nathan Goodyear

Glutathione S-transferase polymorphisms in MS: their relationship to disability. - PubM... - 0 views

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    Polymorphisms in GST appear to play a role in MS.
Nathan Goodyear

http://www.anh-usa.org/wp-content/uploads/2010/03/1Estriol_MS_2.pdf - 0 views

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    High dose Estriol found to be effective therapy in Th1 MS.  This pilot study used 8mg of Estriol daily.
Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

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    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
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  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
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    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency-re... - 0 views

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    case study of a young boy with MADD treated with ketones. Significant improvement/resolution after 5 months of therapy with ketone therapy.  There was even improvement in brain MRI.
toxlab

Tox lab billing and collections - 2 views

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    To ease off the process of tox lab billing and collections, Nath has rolled out software which is a perfect blend of multiple processes, contemporary technology and the manpower involved. Check out today and incorporate it into your system effortlessly!
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In ... - 0 views

  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
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  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
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    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
wheelchairindia9

R O M Knee Brace - 0 views

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    PF Night Splint Compared to plantar based splints, patients prefer dorsal models because they are less bulky, cooler, lower profile and easier to walk in at night. PF Night Splint includes all of these features and more. Neoprene calf and toe straps along with gel padding on the top of the foot help reduce pressure points and the plastic-free bottom offers safer nighttime ambulation. Even added more room in the forefoot to accommodate wider feet and new flexible shell allows easier nighttime ambulation without compromising the ability to hold the foot at 90° during rest. Finally, a plantar fasciitis splint patients will wear all night! Neoprene calf. Padded foam liner. Fits right or left. Not made with natural rubber latex. PF Night Splint (Derotation) Applications Prevention and correction of foot drop. Night splint for early healing. Ambulatory, can be used as a day splint. Perfect post-operative immobilisation and derotation. Peroneal / Peritibial nerve or muscle damage. Ankle or Plantar flexion contracture and functional alignment. Can be used to protect the diabetic/ injured ankle & foot. PF Night Splint (Derotation) Features Removable de-rotation bar. Moulded foot casing, aesthetically pleasing and durable. Effective Liner, improved comfort. Highly functional Design, customized degree of dorsiflexion. Double strapping mechanism, better grip. Tynor R O M Knee Brace Prefabricated, custom adjusted R.O.M. Knee Brace controls and restrict flexion/extension of the knee joint through a multi-point joint fixation system to allow a range of motion or immobilization to the knee. Universal design allows it to be used on quite a big range of population and for a multiple orthopedic problems associated with knee joint. Immobilization at any angle Controlled motion between any two angles Quick and easy application and removal. Tynor R O M Knee Brace Features R.O.M. Dial 0 to 120 degree flexion. 0 to 60 degree hyper extention Locking at any
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