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Nathan Goodyear

Access : Cardiovascular effects of leptin : Nature Reviews Cardiology - 0 views

www.nature.com/...nrcardio.2009.224.html

cardiovascular leptin effects

shared by Nathan Goodyear on 24 May 11 - No Cached
  • obesity and hyperleptinemia have often been associated with hypertension, and regulation of sympathetic tone or direct effects of leptin on contributors such as atherosclerosis, endothelial dysfunction, and thrombosis have been documented
  • Nathan Goodyear on 24 May 11
     
    Leptin and cardiovascular disease
Nathan Goodyear

Weight Regain after a Diet-Induced Loss Is Predicted by Higher Baseline Leptin and Lowe... - 0 views

jcem.endojournals.org/...5037.abstract

weight loss overweight obesity leptin ghrelin

shared by Nathan Goodyear on 31 May 11 - No Cached
  • Appetite-related hormones may play an important role in weight regain after obesity therapy.
  • Subjects with higher plasma leptin and lower ghrelin levels at baseline could be more prone to regain lost weight
  • Nathan Goodyear on 31 May 11
     
    leptin plays role in rebound weight gain after "diet" programs
Nathan Goodyear

Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased... - 0 views

www.ncbi.nlm.nih.gov/...PMC535701

sleep leptin ghrelin overweight weight loss obesity

shared by Nathan Goodyear on 14 Jul 11 - No Cached
  • Participants with short sleep had reduced leptin and elevated ghrelin
  • Nathan Goodyear on 14 Jul 11
     
    poor sleep reduces leptin and elevates ghrelin.  This will contribute to weight gain.
Nathan Goodyear

ScienceDirect.com - Cell Metabolism - Estrogen Receptors and the Metabolic Network - 0 views

www.sciencedirect.com/...S1550413111003123

ER-alpha ER-beta estrogen receptor receptors metabolic syndrome MetS hormone hormones

shared by Nathan Goodyear on 11 Oct 12 - No Cached
  • The pro-opiomelanocortin (POMC) neurons have an anorexigenic action and, when activated, reduce food intake through the release of two peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine-and-amphetamine-regulated transcripts (CART). The neuropeptide Y (NPY) neurons, on the other hand, release NPY hormone and agouti gene-related protein (AgRP), which prevent the binding of α-MSH to MC3R and MC4R, increasing food intake
  • This suggests that the central anorexic effects of E2 may occur via ERβ
  • The main hypothalamic areas involved in food intake and satiety are the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), the ventromedial hypothalamus (VMH), and the dorsomedial hypothalamus (DMH)
  • ...22 more annotations...
  • Leptin is a potent anorexigenic and catabolic hormone secreted by adipose cells that reduces food intake and increases energy expenditure
  • E2 not only modulates leptin receptor mRNA in the ARC and VMH, but also increases hypothalamic sensitivity to leptin, altering peripheral fat distribution
  • ghrelin. It acts on growth hormone secretagogue receptors (GHSR1a) located in the ARC and is a potent stimulator of food intake
  • It thus appears that of the two ERs, ERα plays a predominant role in the CNS regulation of lipid and carbohydrate homeostasis.
  • Both ERs have been identified in the ARC
  • Stimulation of MCH neurons increases food intake and fat accumulation while its inhibition leads to decreased food intake and reduced fat accumulation.
  • Both ERs have been identified in the LH
  • both ERs have been identified in this nucleus
  • The PVN is the region of the hypothalamus with the highest expression of ERβ and is reported to be weakly ERα positive
  • The VMH is ERα regulated
  • Skeletal muscle is responsible for 75% of the insulin-induced glucose uptake in the body
  • GLUT4 is highly expressed in muscle and represents a rate-limiting step in the insulin-induced glucose uptake
  • data suggest that in the physiological range, E2 is beneficial for insulin sensitivity, whereas hypo- or hyperestrogenism is related to insulin resistance
  • In aging female rats, E2 treatment improves glucose homeostasis mainly through its ability to increase muscle GLUT4 content on the cell membrane
  • It is evident that ERα and ERβ have distinct actions and that much more research is needed to clearly identify the function of each receptor in muscle.
  • E2 prevents accumulation of visceral fat, increases central sensitivity to leptin, increases the expression of insulin receptors in adipocytes, and decreases the lipogenic activity of lipoprotein lipase in adipose tissue
  • In rats, ovariectomy increases body weight, intra-abdominal fat, fasting glucose and insulin levels, and insulin resistance followed by decreased phosphorylation of AMPK and its substrate acetyl-CoA carboxylase in adipose tissue
  • decreased adiponectin, PPARγ coactivator-1α (PGC-1α), and uncoupling protein 2 (UCP2) and increased resistin
  • Men with aromatase deficiency have truncal obesity, elevated blood lipids, and severe insulin resistance
  • Although not all studies are in agreement, polymorphisms of ERα in humans have been associated with risk factors for CVDs
  • Human subcutaneous and visceral adipose tissues express both ERα and ERβ, whereas only ERα mRNA has been identified in brown adipose tissue
  • suggesting that ERα is the main regulator of GLUT4 expression in adipose tissue
  • Nathan Goodyear on 11 Oct 12
     
    very nice article that looks at the balance of ER-alpha/ER-beta and their role in metabolic syndrome.  This article discusses the balance of  these receptors are tissue dependent in their effect.  I like their conclusion: "...but these mechanisms will never be completely understood if they are not considered in the context of a whole system.
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21826100

leptin leptin resistance obesity probiotics metabolic syndrome gut gut flora gut microbiota

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Only abstract available here.  Review finds probiotics can be used in the arsenal to treat obesity and metabolic syndrome.  The authors conclude that leptin sensitivity is one of the possible mechanisms.
Nathan Goodyear

http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN106_03%2FS000711451100033Xa... - 0 views

journals.cambridge.org/download.php

sugar fructose leptin leptin resistance diet nutrition obesity

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    elimination of sugar, fructose in rat model found to reverse leptin resistance.
Nathan Goodyear

Exercise protects against high-fat diet-induced hypothalamic inflammation. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22483785

exercise inflammation insulin resistance leptin resistance leptin insulin microglia diet nutrition

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    regular treadmill exercise reduced hypothalamic inflammation, improved insulin resistance, improved leptin resistance, improved glucose tolerance, and decreased microglia activation in high-fat animal model.
Nathan Goodyear

Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglycerid... - 0 views

www.ncbi.nlm.nih.gov/...20222050

curcumin polyphenols leptin obesity leptin resistance insulin insulin resistance fructose diet

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    curcumin found to reduce leptin resistance and insulin resistance in fructose-induced hypertriglyceridiemia in rat model.
Nathan Goodyear

Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese chil... - 0 views

www.ncbi.nlm.nih.gov/...11444441

leptin hormones fat obesity weight-loss Testosterone male hormones

shared by Nathan Goodyear on 04 Feb 17 - No Cached
  • Nathan Goodyear on 04 Feb 17
     
    weight loss decreases leptin in boys and the result is an increase in Testosterone
Nathan Goodyear

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23... - 0 views

jcem.endojournals.org/...1655.abstract

leptin PTH obesity

shared by Nathan Goodyear on 25 May 12 - No Cached
  • Nathan Goodyear on 25 May 12
     
    high leptin, high PTH, fibroblastic growth factor, and bone alkaline phosphatase associated with obesity.
Nathan Goodyear

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Relat... - 0 views

content.onlinejacc.org/...1201

leptin obesity overweight inflammation CVD cardiovascular disease

shared by Nathan Goodyear on 15 Nov 11 - No Cached
  • Nathan Goodyear on 15 Nov 11
     
    Leptin plays central role in obesity and inflammatory conditions
Nathan Goodyear

Obesity - Relation of Leptin to Insulin Resistance Syndrome in Children - 0 views

www.nature.com/...oby2003153a.html

insulin resistance leptin childhood obesity IR children

shared by Nathan Goodyear on 15 Nov 11 - No Cached
  • Nathan Goodyear on 15 Nov 11
     
    leptin and insulin resistance and the web they play in childhood obesity
Nathan Goodyear

Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats - 0 views

ajpendo.physiology.org/...E949.full

leptin gherlin obesity overweight weight-loss weight

shared by Nathan Goodyear on 21 Nov 11 - No Cached
  • Nathan Goodyear on 21 Nov 11
     
    leptin sensitivity and not gherlin shown to play role in obesity in Diet induce obesity rat model
Nathan Goodyear

Ghrelin, leptin, adiponectin, and insulin levels a... [Menopause. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21449093

obesity ghrelin leptin adiponectin insulin weight-loss overweight menopause

shared by Nathan Goodyear on 21 Nov 11 - No Cached
  • Nathan Goodyear on 21 Nov 11
     
    ghrelin, leptin, adiponectin, and insulin weave a complex web in obesity
Nathan Goodyear

Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17725965

Leptin adrenal HPA hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin inhibits hormone production from the adrenal cortex, but increases catecholamine release from the adrenal medulla.
Nathan Goodyear

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regula... - 0 views

www.nature.com/...ncomms7266.html

Leptin HPA hormone hormones

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    Leptin does have inhibitory activity at the level at the HPA; in addition to the inhibition at the gonadal level.
Nathan Goodyear

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. - P... - 0 views

www.ncbi.nlm.nih.gov/...9275075

leptin CRH HPA axis HPA hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin inhibits CRH, thus decreasing the HPA axis.
Nathan Goodyear

Neuronal protein tyrosine phosphatase 1B deficienc... [Mol Cell Biol. 2009] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...19528236

leptin weight loss obesity overweight

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • the mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues.
  • Nathan Goodyear on 08 Mar 11
     
    improved leptin sensitivity leads to weight loss and increased energy expenditure
Nathan Goodyear

Research on Leptin Biological Characters and Mechanism of Controlling Weigh--... - 0 views

en.cnki.com.cn/...CJFDTOTAL-GZTX200603025.htm

leptin research weight loss

shared by Nathan Goodyear on 04 Mar 11 - No Cached
  • Nathan Goodyear on 04 Mar 11
     
    leptin physiology and weight loss
Nathan Goodyear

Journal of Clinical Investigation -- Pathophysiological role of leptin in obesity-relat... - 0 views

www.jci.org/...1

leptin resistance obesity hypertension

shared by Nathan Goodyear on 04 Mar 11 - No Cached
  • Nathan Goodyear on 04 Mar 11
     
    leptin-resistance as cause of obesity and contribution to hypertension
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