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Nathan Goodyear

Leptin stimulates fatty-acid oxidation by activati... [Nature. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11797013

leptin fat obesity

shared by Nathan Goodyear on 10 Mar 11 - No Cached
  • Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of fatty acids and the uptake of glucose, and prevents the accumulation of lipids in nonadipose tissues, which can lead to functional impairments known as "lipotoxicity"
  • Nathan Goodyear on 10 Mar 11
     
    Leptin and fat accumulation called "lipotoxicity"
Nathan Goodyear

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Relat... - 0 views

content.onlinejacc.org/...1201

leptin resistance obesity inflammation

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6
  • Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk
  • Nathan Goodyear on 12 Apr 11
     
    leptin resistance, inflammation and obesity
Nathan Goodyear

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension - 0 views

diabetes.diabetesjournals.org/...2012.short

obesity leptin resistance cardiovascular disease

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Nathan Goodyear on 21 Apr 11
     
    leptin resistance and thus elevated leptin increase cardiovascular complications
Nathan Goodyear

Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men: T... - 0 views

press.endocrine.org/...jcem.82.8.4174

Testosterone leptin low T low Testosterone low T hypogonadism male men hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Study of hypogonadal men with low T and elevated leptin levels finds that Testosterone therapy reduced leptin levels.
Nathan Goodyear

Androgen Therapy Improves Insulin Sensitivity and Decreases Leptin Level in Healthy Adu... - 0 views

care.diabetesjournals.org/...2149.extract

low T low Testosterone leptin obesity Testosterone therapy insulin resistance

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • Nathan Goodyear on 22 Oct 14
     
    Three month study of men with low T, found that Testosterone therapy improved insulin sensitivity and reduced leptin levels.  The group of men here were described as "healthy, non-obese men".   Remember, low T is a biomarker of poor health in men, so the authors statement about the study group is inaccurate.  This also points to a relatively quick metabolic effect by Testosterone and a direct effect on insulin receptor effect and adipocyte leptin release.
Nathan Goodyear

ScienceDirect.com - Physiology & Behavior - Effects of leptin and orexin-A on food inta... - 0 views

www.sciencedirect.com/...S0031938400003413

leptin orexins appetite

shared by Nathan Goodyear on 28 May 13 - No Cached
  • orexin-A and orexin-B, localized in the posterior and lateral hypothalamic perifornical region were discovered in the rat brain and they increase food intake
  • Leptin, a protein encoded by an obesity gene, expressed in adipose tissue and released into the blood also affects food intake
  • Nathan Goodyear on 28 May 13
     
    Leptin and orexins regulate appetite regulate food intake.
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and lep... - 0 views

ajpendo.physiology.org/...E649.long

exercise insulin resistance leptin resistance leptin insulin PTP1B

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    exercise found to improve central insulin and leptin resistance in obese animal model.  The mechanism was via a decrease in inflammation through decrease in PTP1B protein transcription.
Nathan Goodyear

High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in ma... - 0 views

www.sciencedirect.com/...S0955286314000023

fructose HFCS leptin leptin resistance obesity visceral fat triglycerides diet nutrition

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    high fructose diet for just 9 weeks, > 60% liquid fructose, in rat model found to increase visceral adiposity, triglycerides, and lead to leptin resistance.
Nathan Goodyear

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic O... - 0 views

www.ncbi.nlm.nih.gov/...PMC3198091

prebiotics probiotic Bifidobacterium leptin resistance leptin glucose lipids inflammation LPS

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    prebiotics found to increase leptin sensitivity, improved glucose metabolism, lipid metabolism, reduced inflammation and improved leaky gut.  The probiotics increased the bifidobacterium species versus a decrease in the Firmicutes phyla.
Nathan Goodyear

Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat... - 0 views

dl-web.dropbox.com/...Leptin%20Testing.pdf

leptin hormone weight loss overweight obesity

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    Dr. Braverman nicely discusses the importance of evaluating leptin in the evaluation of obesity.
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

www.andrologyjournal.org/...534

leptin resistance low T testosterone low T hormone hormones insulin cardiovascular disease men male

shared by Nathan Goodyear on 28 Aug 12 - No Cached
  • Nathan Goodyear on 28 Aug 12
     
    leptin resistance, increased leptin, reduces testosterone production in men.
Nathan Goodyear

Obesity, adipocytokines, and cancer - 0 views

dl-web.dropbox.com/...ytokines%2C%20and%20cancer.pdf

adipocytokines leptin adiponectin inflammation cancer insulin resistance IR obesity

shared by Nathan Goodyear on 12 Jan 12 - No Cached
  • Nathan Goodyear on 12 Jan 12
     
    adipocytokines, such as leptin and adiponectin, impact much more than insulin resistance and obesity. Leptin and adiponectin play some role in the development of certain cancers. Bringing together the common thread of inflammation
Nathan Goodyear

Metabolic influences on neuroendocrine regulation of reproduction - 0 views

www.ncbi.nlm.nih.gov/...PMC3898855

metabolism metabolic regulation reproduction Leptin Ghrelin Insulin Kisspeptin GNRH

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
  • humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
  • Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
  • ...4 more annotations...
  • GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
  • AgRP and NPY have the opposite (orexigenic) effect, inducing food intake.
  • Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
  • Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.
  • Nathan Goodyear on 17 Feb 14
     
    Good, although brief, discussion of the interaction between metabolism and hormones.  Kisspeptin is a GNRH secreatagogue "upstream".   Insulin, Leptin, and Gherlin can inhibit GNRH through resistance and low levels.  Probably a U shaped graph of optimal activity.
Nathan Goodyear

http://www.researchgate.net/profile/Costanzo_Moretti/publication/12777565_Leptin_and_an... - 0 views

www.researchgate.net/...02bfe50e5334207a93000000.pdf

leptin low T low Testosterone obese men male hormone hormones obesity

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Normal leptin levels are critical to puberty; but in obese men, increased leptin is associated with gonadal decrease in Testosterone.  It appears to occur through a decrease in 17-OH progesterone to Testosterone: suggesting an inhibitory activity in the conversion of 17-OH progesterone to Testosterone in obese men.
Nathan Goodyear

Importance of TNF-alpha and leptin in obesity and ... [Exerc Immunol Rev. 1998] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...9644096

obesity leptin inflammation exercise

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • weight loss reduces adipose TNF-alpha expression and serum leptin levels and is associated with improved insulin sensitivity and lipid metabolism
  • Nathan Goodyear on 08 Mar 11
     
    weight loss reduces adipose inflammation signaling, TNF-alpha expression, and serum leptin levels and is associated with improved insulin sensitivity and lipid metabolism.
Nathan Goodyear

Study finds leptin plays a key role in women's health | Harvard Gazette - 0 views

news.harvard.edu/...ys-a-key-role-in-womens-health

leptin

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    Leptin improves weight and fertility in under weight women
Nathan Goodyear

Leptin and obesity--《Chinese Journal of Pathophysiology》2003年07期 - 0 views

en.cnki.com.cn/...CJFDTOTAL-ZBLS200307037.htm

leptin obesity

shared by Nathan Goodyear on 04 Mar 11 - No Cached
  • This review elucidates the structure, the main biological function, the mechanism of leptin and it's relationship with obesity.
  • Nathan Goodyear on 04 Mar 11
     
    leptin physiology and obesity
Nathan Goodyear

Irvingia: Understanding the Risks of Leptin Resistance - Life Extension - 0 views

www.lef.org/...ks-of-Leptin-Resistance_01.htm

leptin irvingia resistance weight loss obesity

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • Nathan Goodyear on 09 Mar 11
     
    nice review on Leptin resistance and weight gain from LifeExtensions
Nathan Goodyear

Serum leptin concentrations in patients with thyroid disorders - Yoshida - 2001 - Clini... - 0 views

onlinelibrary.wiley.com/...full

leptin thyroid hormone obesity overweight

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • These results indicate that thyroid hormone may play an important role in the appropriate secretion of leptin in humans.
  • Nathan Goodyear on 08 Mar 11
     
    thyroid hormone plays role in stimulating leptin secretion
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