Nutrition & Metabolism | Full text | Fructose, insulin resistance, and metabolic dyslip... - 0 views
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For thousands of years humans consumed fructose amounting to 16–20 grams per day
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daily consumptions amounting to 85–100 grams of fructose per day
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Of key importance is the ability of fructose to by-pass the main regulatory step of glycolysis, the conversion of glucose-6-phosphate to fructose 1,6-bisphosphate, controlled by phosphofructokinase
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Role of Oxidative Stress and the Microenvironment in Breast Cancer Development and Prog... - 0 views
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oxidative stress leads to HIF-1α accumulation
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increased levels of hydrogen peroxide in exhaled breath condensate from patients with localized breast malignancy, associated with increased clinical severity
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Oxidative stress generated by breast cancer cells activates HIF-1α and NFκB in fibroblasts, leading to autophagy and lysosomal degradation of Cav-1
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Really fascinating article on tumor signaling. The article points to a complex signaling between cancer cells and stromal fibroblasts that results in myofibroblast transformation that increases the microenvironment favorability of cancer. This article points to oxidative stress as the primary driving force.
Cancer as a metabolic disease: implications for novel therapeutics - 0 views
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The Crabtree effect involves a glucose-induced suppression of respiration leading to lactate production whether or not mitochondria are damaged
Muscle Hypertrophy 2011 - 0 views
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mechanical tension, muscle damage and metabolic stress are the three primary factors that promote hypertrophy from exercise
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The mechanical tension is directly related to intensity of the exercise, which is the key to stimulating muscle growth
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Muscle damage, that leads to muscle soreness, from exercise training initiates an inflammatory response, which activates satellite cells growth processes
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Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treate... - 0 views
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delayed hemolytic events occur in ≈20% of patients with severe imported malaria, and 60% of these patients require blood transfusion
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Delayed-onset anemia (herein referred to as postartesunate delayed-onset hemolysis [PADH] pattern of anemia) has been observed to occur 2–3 weeks after initiation of IV artesunate
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The mechanism of this anemia is hemolytic, as demonstrated by high serum lactate dehydrogenase (LDH) and low plasma haptoglobin levels
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The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cance... - 0 views
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biochemistry strikes again: hexokinase 2 shown to be key step in cancer proliferation, energy metabolism and mortality. 3BP shown to be a potent glycolytic inhibitor and in animal studies shown to have significant mortality effects on cancer. Also, great review of cancer cell metabolism i.e Warburg effect, Crabtree effect, LDH, PD, PDK...
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for ... - 0 views
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The ‘Glucose Ketone Index’ (GKI) was created to track the zone of metabolic management for brain tumor management
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The GKI is a biomarker that refers to the molar ratio of circulating glucose over β-OHB, which is the major circulating ketone body.
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We present evidence showing that the GKI can predict success for brain cancer management in humans and mice using metabolic therapies that lower blood glucose and elevate blood ketone levels
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Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views
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Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
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Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
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ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
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The future of cancer therapy is cancer stem cells. Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells. Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs. The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
Metabolic Regulation of Macrophage Polarization in Cancer - PMC - 1 views
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