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Nathan Goodyear

Endurance exercise performance: the physiology of champions - 0 views

jp.physoc.org/...35.full

endurance exercise performance physiology

shared by Nathan Goodyear on 29 Apr 13 - No Cached
  • Nathan Goodyear on 29 Apr 13
     
    great review on performance physiology.  This article reviews  how VO2 max, lactate threshold, performance VO2, and mitochondria contribute to peak endurance performance.
Nathan Goodyear

alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and imp... - 0 views

care.diabetesjournals.org/...280.abstract

alpha-lipoic-acid alpha lipoic acid type II DM diabetes lactic lactate pyruvate ALA

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    alpha lipoic acid improves glucose control in individuals with type II DM.  This study showed decreased lactic acid and pyruvate levels with alpha lipoic acid therapy.  Therapy in this study consisted of ALA of 600 mg twice daily.
Nathan Goodyear

Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older... - 0 views

www.ncbi.nlm.nih.gov/...PMC3110835

Cordyceps Cordyceps sinensis exercise performance

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Cordyceps improved lactate threshold and improved exercise performance in healthy, older people.  The dosing was 333mg TID.
Nathan Goodyear

Cordyceps sinensis promotes exercise endura... [J Ethnopharmacol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21549819

Cordyceps Cordyceps sinensis exercise performance

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Cordyceps supplementation at 200 mg/kg/day improves exercise endurance capacity.  Parameters found: angiogenesis, improved glucose uptake, improved lactate uptake.  This occurred in both those rats in the exercise arm and those in the non-exercise arm.
Nathan Goodyear

Access : Oxytocin increases trust in humans : Nature - 0 views

www.nature.com/...nature03701.html

oxytocin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    Oxytocin has more than effects on labor and lactation.  Oxytocin has benefit in mood, particularly trust in this study.
Nathan Goodyear

European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views

www.nature.com/...ejcn2014158a.html

nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity

shared by Nathan Goodyear on 22 Dec 14 - No Cached
  • It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
  • An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
  • The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
  • ...8 more annotations...
  • Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
  • Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
  • increased adiposity, once established in childhood, tends to track into adulthood
  • Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
  • The acquisition of fat cells early in life appears to be an irreversible process
  • Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
  • In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
  • our systematic review highlights that most of the trials reviewed were prone to methodological limitations
  • Nathan Goodyear on 22 Dec 14
     
    Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.
Nathan Goodyear

http://www.tandfonline.com/doi/pdf/10.4161/cc.8.23.10238 - 0 views

www.tandfonline.com/...cc.8.23.10238

reverse warburg effect war warburg effect cancer mono-carboxylate transporters CAFs fibroblasts

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • Nathan Goodyear on 11 Nov 14
     
    Good biochemical review of the Reverse Warburg Effect.  In pdf format, so I can't highlight.
Nathan Goodyear

Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation - 0 views

www.ncbi.nlm.nih.gov/...PMC3601023

cancer DCA

shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • the oral bioavailability of DCA is nearly 100%
  • the oral bioavailability of DCA is almost 100%.
  • DCA can penetrate into the traditional chemotherapy sanctuary sites. Interestingly, it was reported that DCA could penetrate across the BBB,30 exhibiting the potential activity for brain therapy.
  • ...23 more annotations...
  • Clinical studies of DCA have shown reduced lactate levels
  • It has been reported that DCA activates the PDH by inhibition of PDK in a dose-dependent manner, and results in increased delivery of pyruvate into the mitochondria
  • The antitumor activity of DCA on nonsmall cell lung cancer, breast cancer, glioblastomas, and endometrial and prostate cancer cells has been demonstrated
  • It is well known that many chemotherapeutic agents have a low therapeutic index in brain tumors.
  • The most common metabolic hallmark of cancer cells is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen
  • Pyruvate dehydrogenase kinase (PDK) is a gate-keeping enzyme that regulates the flux of carbohydrates (pyruvate) into the mitochondria
  • In the presence of activated PDK, pyruvate dehydrogenase (PDH), a critical enzyme that converts pyruvate to acetyl-CoA instead of lactate in glycolysis, is inhibited, limiting the entry of pyruvate into the mitochondria.
  • the level of Hsp70 was significantly decreased
  • DCA can penetrate the BBB
  • It has been reported that DCA treatment resulted in an increase in the proportion of tumor cells in the S phase, showing a decrease in proliferation as well as the induction of apoptosis
  • Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport, and/or stabilization by acting as a molecular chaperone, leading to the inhibition of apoptosis by both caspase-dependent and/or independent pathways
  • HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, and metastasis
  • Considering the fact that high expression of HSPs is essential for cancer survival, the inhibition of HSPs is an important strategy of anticancer therapy.
  • In addition, after 5 years of continued treatment with oral DCA at a dose of 25 mg/kg, the serum DCA levels are only slightly increased compared with the levels after the first several doses, also showing its safety for oral administration at this dose.
  • DCA can enter the circulation rapidly after oral administration and then generate the stimulation of PDH activity generally within minutes.
  • Our in vivo results in tumor tissues indicated that DCA significantly induced ROS production and decreased MMP in tumor tissues
  • The numbers of microvessels in the DCA treatment groups were significantly decreased, suggesting the potential antiangiogenic effect of DCA
  • Under hypoxic conditions, hypoxia-inducible factor (HIF-1α) is activated and induces angiogenesis
  • In addition, HIF-1α can also induce the expression of PDK,48 which can inhibit the activity of PDH
  • The inhibition effect of DCA on HIF-1α would decrease vascular endothelial growth factor and inhibit angiogenesis
  • the antiangiogenic effect in the 25 mg/kg treatment group was lower than that in 75 mg/kg or 125 mg/kg treatment groups
  • In conclusion, DCA induces the apoptosis of C6 cells through the activation of the mitochondrial pathway, arresting the cell cycle of C6 cells in S phase and down-regulating Hsp70 expression.
  • DCA significantly induced the ROS production and decreased the MMP in tumor tissues. Our in vivo antitumor activity results also indicated that DCA has an antiangiogenic effect
  • Nathan Goodyear on 12 Nov 14
     
    DCA as proposed therapy in cancer.
Nathan Goodyear

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Ac... - 0 views

cancerres.aacrjournals.org/...2677.long

pH acid tumor cancer alkaline NaHCO3

shared by Nathan Goodyear on 19 Nov 18 - No Cached
  • Nathan Goodyear on 19 Nov 18
     
    Great diagram of the pH in/around solid tumors. Cancer exists in an obvious hypoxic environment which favors the HIF-1alpha which favors lactate production which drops the pH in the tumor extracellular environment effecting chemoresistance, radioresistance, angiogenesis, invasion, aggressiveness, metastasis, immune evasion...
Nathan Goodyear

Acidic extracellular microenvironment and cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3849184

acid tumor cancer cancer lactate "lactic acid"

shared by Nathan Goodyear on 16 Nov 18 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 16 Nov 18
     
    Cancer thrives in an acidic micro environment, which also limits penetration of the immune system and other therapies often used in the treatment of cancer.
Nathan Goodyear

Serum lactate dehydrogenase and survival following cancer diagnosis - 0 views

www.ncbi.nlm.nih.gov/...PMC4815785

LDH 'lactate dehydrogenase cancer

shared by Nathan Goodyear on 08 Jun 18 - No Cached
  • Nathan Goodyear on 08 Jun 18
     
    LDH found to correlate with overall and cancer-specific mortality.
Nathan Goodyear

H2O2-mediated Cytotoxicity of Pharmacologic Ascorbate Concentrations to Neuroblastoma C... - 0 views

www.karger.com/...315098

Ferritin H2O2 vitamin C lactate cancer

shared by Nathan Goodyear on 08 Jul 19 - No Cached
  • Nathan Goodyear on 08 Jul 19
     
    Study finds that ferritin in the tumor microenvironment is critical to the cytotoxicity elicited through its interaction with vitamin C through H2O2.
Nathan Goodyear

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer ... - 0 views

pubmed.ncbi.nlm.nih.gov/30688660

cancer stem cells breast cancer CSC LDH lactate dehydrogenase stress cancer epinephrine

shared by Nathan Goodyear on 22 Jul 22 - No Cached
  • Nathan Goodyear on 22 Jul 22
     
    Epinephrine increases LDH-A in breast cancer
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