Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views
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These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
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major site for the oxidation of cortisol to cortisone is the kidney
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congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
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Therapy in the Early Stage: Incretins - 0 views
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Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
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in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
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β-cell failure
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Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views
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he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
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Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
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The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
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Potential Mechanisms of Estrogen Quinone Carcinogenesis - 0 views
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4-hydroxyestrone/estradiol was found to be carcinogenic in the male Syrian golden hamster kidney tumor model, whereas, 2-hydroxylated metabolites were without activity
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4-hydroxyestradiol induced uterine tumors in 66% of CD-1 mice; whereas, mice treated with 2-hydroxyestradiol or 17β-estradiol had much lower uterine tumor incidence
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DNA adducts of catechol estrogen quinones have been detected in the mammary glands of ACI rats treated with 4-hydroxyestradiol or it’s quinone
Environmental Health | Abstract | Arsenic in drinking water and cerebrovascular disease... - 0 views
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suggest that exposure to low-to-moderate levels of arsenic in drinking water may be associated with several of the leading causes of mortality
Magnesium metabolism in health and disease. [Dis Mon. 1988] - PubMed result - 0 views
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Less than 1% of the total body magnesium is present in blood
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A large segment of the U.S. population may have an inadequate intake of magnesium and may have a chronic latent magnesium deficiency that has been linked to atherosclerosis, myocardial infarction, hypertension, cancer, kidney stones, premenstrual syndrome, and psychiatric disorders.
Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views
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The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
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Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
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With chronic exposure over a long period of time, most absorbed lead ends up in bone
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You can live a more healthy life than that - 0 views
Join us in changing lives through 4Life Transfer Factor. Using Science, Success, and Service we'll work Together, Building People. 4life offers products that boost immune system and improve general...
Anemia in cancer - 0 views
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Anemia is a frequent finding in cancer patients, occurring in >40% of cases
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chemotherapy, the incidence of anemia may rise to 90%
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Anemia exerts a negative influence on the quality of life
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Great review of anemia in Cancer: 1) blood loss 2) increased RBC loss 3) decreased RBC production Cancer infiltration of marrow can reduce hematopoiesis. Inflammatory cytokines can reduce hematopoiesis. Inflammatory cytokines can block Fe absorption. Chemo and radiation can cause anemia--particularily platinum based therapies.
How to Deal with it When Blood Pressure Falls During Dialysis - 0 views
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"Dear, doctor. Is there natural home remedies for kidney disease, especially for Creatinine 8.1 patients. Many patients asked about what to do when blood pressure falls during dialysis and consequences of doing dialysis. My father is a CKD stage 3 and sufferer from pain on his left side between and left hip and last rib. How to alleviate it?"
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