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Nathan Goodyear

The Detoxification Enzyme Systems - 0 views

www.adltests.com/...etoxification_Review_Liska.pdf

detoxification detox liver kidney

shared by Nathan Goodyear on 29 Oct 12 - No Cached
  • Nathan Goodyear on 29 Oct 12
     
    Great review of phase I and II detoxification pathways and mechanisms.
Nathan Goodyear

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative... - 0 views

www.ncbi.nlm.nih.gov/...20186128

blood pressure hypertension vitamin C oxidative stress

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    animal study finds vitamin C improves hypertension via renovascular source and oxidative stress.  The dosage was 150 mg/kg/day.  This would be equivalent to 10,800 grams daily for a 72 human.  But what about a 200 lb male or female?  That would be 13,650 grams of vitamin C daily.
Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

www.ncbi.nlm.nih.gov/...PMC303514

cortisol mineralcorticoid low potassium hypokalemia hypertension 11-betaHSD

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
  • Nathan Goodyear on 24 Apr 12
     
    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Environmental Health | Full text | Arsenic in drinking water and cerebrovascular diseas... - 0 views

www.ehjournal.net/4

arsenic diabetes environmental health disease mortality drinking

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    low levels of Arsenic in drinking water in Michigan shown to increase diabetes and other diseases
Nathan Goodyear

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the met... - 0 views

ajcn.nutrition.org/...899.short

fructose diabetes hypertension metabolic syndrome cardiovascular disease obesity nutrition

shared by Nathan Goodyear on 19 Sep 13 - No Cached
  • Nathan Goodyear on 19 Sep 13
     
    Fructose implicated in just about every chronic disease of aging through obesity.
Nathan Goodyear

Effect of intravenous ascorbic ac... [Saudi J Kidney Dis Transpl. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18974579

IV vitamin C IV vitamin C antioxidant antioxidants

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    IV vitamin C safe and improves response to EPO in those on hemodialysis.
Nathan Goodyear

Therapy in the Early Stage: Incretins - 0 views

care.diabetesjournals.org/...S264.full

incretins glucose diabetes

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
  • in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
  • β-cell failure
    • Nathan Goodyear
      Nathan Goodyear on 11 Dec 13
       
      and studies have shown that a reduction in insulin function will decrease LH production and thus lead to a decrease in Testosterone production in men.
  • ...2 more annotations...
  • Incretins are gut-derived hormones, members of the glucagon superfamily, released in response to nutrient ingestion (mainly glucose and fat)
  • They exert a wide range of effects, including stimulation of pancreatic insulin secretion in a glucose-dependent manner and play an important role in the local gastrointestinal and whole-body physiology
  • Nathan Goodyear on 11 Dec 13
     
    good discussion on incretins and their role in glucose homeostasis. 
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

Potential Mechanisms of Estrogen Quinone Carcinogenesis - 0 views

www.ncbi.nlm.nih.gov/...PMC2556295

estrogen metabolites estrogen quinones 4-OH-estrone cancer hormones

shared by Nathan Goodyear on 19 Sep 15 - No Cached
  • 4-hydroxyestrone/estradiol was found to be carcinogenic in the male Syrian golden hamster kidney tumor model, whereas, 2-hydroxylated metabolites were without activity
  • 4-hydroxyestradiol induced uterine tumors in 66% of CD-1 mice; whereas, mice treated with 2-hydroxyestradiol or 17β-estradiol had much lower uterine tumor incidence
  • DNA adducts of catechol estrogen quinones have been detected in the mammary glands of ACI rats treated with 4-hydroxyestradiol or it’s quinone
  • Nathan Goodyear on 19 Sep 15
     
    great read on the proposed mechanisms of how estrogen metabolites produce quinone intermediates that are carcinogenic.
Nathan Goodyear

Kidney International - Abstract of article: Inflammation enhances cardiovascular risk a... - 0 views

www.nature.com/...4490624a.html

inflammation CRP cardiovascular disease risk

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • Nathan Goodyear on 04 Feb 11
     
    Inflammation (point 5 of 5 points of wellness) increases CRP, which increases cardiovascular risk
Nathan Goodyear

Environmental Health | Abstract | Arsenic in drinking water and cerebrovascular disease... - 0 views

www.ehjournal.net/...abstract

Arsenic drinking water environmental health

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • suggest that exposure to low-to-moderate levels of arsenic in drinking water may be associated with several of the leading causes of mortality
  • Nathan Goodyear on 08 Mar 11
     
    low levels of Arsenic in drinking water contribute to cerebrovascular disease, diabetes, and cancer
Nathan Goodyear

Magnesium metabolism in health and disease. [Dis Mon. 1988] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...3282851

magnesium disease health

shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Less than 1% of the total body magnesium is present in blood
  • A large segment of the U.S. population may have an inadequate intake of magnesium and may have a chronic latent magnesium deficiency that has been linked to atherosclerosis, myocardial infarction, hypertension, cancer, kidney stones, premenstrual syndrome, and psychiatric disorders.
  • Nathan Goodyear on 21 Mar 11
     
    Magnesium in health and disease
Nathan Goodyear

Protective effect of reduced glutathione ... [Chem Biol Interact. 1989] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2736678

glutathione cisplatin chemotherapy toxicity renal kidney systemic

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    glutathione protects against cisplatin induced toxicities
Nathan Goodyear

Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views

www.aafp.org/...stauding.html

occupational poisoning lead

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
  • Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
  • With chronic exposure over a long period of time, most absorbed lead ends up in bone
  • ...4 more annotations...
  • The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
  • n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
  • hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.
  • Late effects may include chronic renal failure, hypertension, gout and chronic encephalopathy.6
  • Nathan Goodyear on 05 Jul 11
     
    occupational lead poisoning
Nathan Goodyear

Effect of intravenous ascorbic acid in hemod... [Am J Kidney Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16564942

IV vitamin C IV vitamin C antioxidant antioxidants anemia

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    High dose IV vitamin C shown to be well tolerated in those on hemodialysis.  Liver enzymes were followed throughout the course of the 6 month trial.  In fact, IV vitamin C was shown to improve the response of the EPO therapy.
Godwin Daniel

You can live a more healthy life than that - 0 views

Join us in changing lives through 4Life Transfer Factor. Using Science, Success, and Service we'll work Together, Building People. 4life offers products that boost immune system and improve general...

low cholesterol obesity lose weight fast blood sugar bone brain cancer ulcer kidney bladder

started by Godwin Daniel on 02 Dec 14 no follow-up yet
Nathan Goodyear

Anemia in cancer - 0 views

annonc.oxfordjournals.org/...vii167.long

cancer anemia

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is a frequent finding in cancer patients, occurring in >40% of cases
  • chemotherapy, the incidence of anemia may rise to 90%
  • Anemia exerts a negative influence on the quality of life
  • ...17 more annotations...
  • Anemia has also been identified as an adverse prognostic factor
  • mild (10 g/dl—normal), moderate (8–10 g/dl), severe (6.5–8 g/dl) and life threatening (<6.5 g/dl or unstable patient) anemia
  • anemia in cancer patients is often multifactorial.
  • Cancer itself can directly cause or exacerbate anemia either by suppressing hematopoiesis through bone marrow infiltration or production of cytokines that lead to iron sequestration, or by reduced red blood cell production
  • in inflammatory anemia, iron deficiency should be defined by a low transferrin saturation of <20%, ferritin levels of <100 ng/ml and a low reticulocyte hemoglobin concentration of <32 pg
  • anemia to thrombocytosis, as commonly seen in cancer patients
  • TNF-α inhibits hemoglobin production
  • treatment itself may be a major cause of anemia
  • Other cytokines, such as interleukin-6 (IL-6), IL-1 and interferon-γ, have also been shown to inhibit erythroid precursors in vitro [9], albeit to a lesser extent
  • In inflammation, from whatever cause, IL-6 induces the liver to produce hepcidin. Hepcidin decreases iron absorption from the bowel and blocks iron utilization in the bone marrow
  • Numerous in vitro studies have illustrated the central role of TNF-α in the pathogenesis of anemia
  • nephrotoxic effects of particular cytotoxic agents such as platinum salts can also lead to the persistence of anemia through reduced Epo production by the kidney
  • Currently two options are at the disposal of the clinician for the treatment of anemia in cancer patients: transfusion of packed red blood cells and the use of erythropoiesis-stimulating agents (ESAs)
  • The goal of the treatment is to relieve the symptoms of anemia such as fatigue and dyspnea.
  • Transfusion of 1 unit of packed red blood cells has been estimated to result in an increase in the hemoglobin level of 1 g/dl in a normal-sized adult
  • a higher mortality rate in patients receiving ESA treatment
  • Recent concerns regarding the risk of thromboembolism in patients treated with ESA have been corroborated by the meta-analyses conducted by Tonnelli and Bennett
  • Nathan Goodyear on 30 Mar 15
     
    Great review of anemia in Cancer:  1)  blood loss 2)  increased RBC loss 3)   decreased RBC production Cancer infiltration of marrow can reduce hematopoiesis.  Inflammatory cytokines can reduce hematopoiesis.  Inflammatory cytokines can block Fe absorption.  Chemo and radiation can cause anemia--particularily platinum based therapies.
star yu

How to Deal with it When Blood Pressure Falls During Dialysis - 0 views

www.huaxiainstitute.com/...169.html

Dialysis Blood Pressure

shared by star yu on 19 Jan 16 - No Cached
  • star yu on 19 Jan 16
     
    "Dear, doctor. Is there natural home remedies for kidney disease, especially for Creatinine 8.1 patients. Many patients asked about what to do when blood pressure falls during dialysis and consequences of doing dialysis. My father is a CKD stage 3 and sufferer from pain on his left side between and left hip and last rib. How to alleviate it?"
Nathan Goodyear

Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidne... - 0 views

ndt.oxfordjournals.org/...608.short

fructose HFCS inflammation CRP insulin nutrition

shared by Nathan Goodyear on 10 Jan 16 - No Cached
  • Nathan Goodyear on 10 Jan 16
     
    low fructose diet decreased CRP, insulin, and uric acid levels.  
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