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Nathan Goodyear

inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induce... - 0 views

ajprenal.physiology.org/...F634.full.pdf

testosterone hormone hormones kidney kidneys diabetes DM renal system aromatase

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    Study finds that inhibition of aromatase activity in diabetic male rats provided renal protection. There has been debate about the effects of testosterone therapy on the renal system. However, I propose that aromatase activity and conversion to estrogen is the negative effects of Testosterone. Other than over dosing men. Though this is a rat study, this study does support the theory.
Nathan Goodyear

Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease - 0 views

hyper.ahajournals.org/...1218.long

renal kidney disease kidney disease renal disease low t low testosterone testosterone estrogen estradiol diabetes DM hormone hormones

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    Diabetes associated with low serum testosterone.  This study points to a 4.7 fold decrease.  This is accompanied by a 2.9 fold increase in estradiol.  Castration worsened this imbalance by decreasing the testosterone level further.  Likely the low T and increased aromatase activity aid in the development of diabetic renal disease. Numerous studies have shown that testosterone therapy improves glucose homeostasis.
Nathan Goodyear

Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Tran... - 0 views

endo.endojournals.org/...609.abstract

thyroid hormone hormones T3 vitamin D

shared by Nathan Goodyear on 13 Feb 13 - No Cached
  • Nathan Goodyear on 13 Feb 13
     
    T3 can suppress kidney production of 1 alpha,25-dihyddroxyvitamin D.
lyfboat

Lyfboat - Medical Travel | Compare hospitals | Find Doctor | Free Cost Estimates - 0 views

www.lyfboat.com

medical travel compare hospitals doctor free cost estimates

shared by lyfboat on 28 Apr 16 - No Cached
  • lyfboat on 28 Apr 16
     
    Lyfboat | Compare best hospitals & doctors worldwide for cancer treatment, heart surgery, liver, kidney transplant, IVF & more. Save money - know your options.
Nathan Goodyear

Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men - NEJM - 0 views

www.nejm.org/...NEJMoa050080

fasting plasma glucose diabetes

shared by Nathan Goodyear on 15 Mar 12 - No Cached
  • Nathan Goodyear on 15 Mar 12
     
    Fasting glucose levels >90 require treatment.  Don't wait until they increase above 100, damage is actively occurring in the kidneys at levels above 90.  institute dietary/lifestyle changes at any point above 84.
star yu

Hay Alguna Esperanza para los Pacientes Etapa 5 Enfermedad Renal Crónica a Di... - 0 views

www.enfermedad-renal.com/...2226.html

Etapa 5 Enfermedad Renal Crónica tratamiento

shared by star yu on 30 Apr 15 - No Cached
  • star yu on 30 Apr 15
     
    Is there any hope for stage 5 chronic kidney disease patient to live a high quality life?As we all know most of the patients with stage 5 will face dialysis or renal transplant, both of them can help them live better but meanwhile they also will bring some side-effect, so either of them can not ensure the kidney disease patient to enjoy a quality life.
Nathan Goodyear

Renoprotective effects of green tea extract on renin-angiotensin-aldosterone system in ... - 0 views

ndt.oxfordjournals.org/...1188.abstract

green tea extract renoprotective effects

shared by Nathan Goodyear on 17 Apr 11 - No Cached
  • Nathan Goodyear on 17 Apr 11
     
    Gree tea extract protects kidneys
star yu

How to Avoid Dialysis for PKD Stage 3 Patients - 0 views

www.huaxiainstitute.com/...190.html

Dialysis PKD Stage 3

shared by star yu on 30 Jan 16 - No Cached
  • star yu on 30 Jan 16
     
    How to avoid dialysis for PKD stage 3 patients? As we all know, Polycystic Kidney Disease is a kind of genetic kidney disease, with the disease goes worse, doctors will recommend dialysis to patient.
Nathan Goodyear

Renin-angiotensin system and cancer: A review - 0 views

www.oatext.com/system-and-cancer-A-review.php

renin angiotensin system cancer

shared by Nathan Goodyear on 10 Sep 18 - No Cached
  • crucial role of the RAS in the development and maintenance of cancer
  • kidneys, which produce renin in response to decreased arterial pressure, reduced sodium in the distal tubule, or sympathetic nervous system activity via the β-adrenergic receptors
  • Renin is secreted from the juxtaglomerular cells into the bloodstream where it encounters angiotensinogen (AGN), normally produced by the liver
  • ...22 more annotations...
  • Renin catalyses the conversion of AGN to angiotensin I (ATI), which is quickly cleaved by angiotensin converting enzyme (ACE) to form angiotensin II (ATII)
  • ATII triggers the release of aldosterone from the adrenal glands, which stimulates reabsorption of sodium and water and thereby increases blood volume and blood pressure
  • ATII also acts on smooth muscle to cause vasoconstriction of the arterioles
  • ATII promotes the release of antidiuretic hormone from the posterior pituitary gland, which results in water retention and triggers the thirst reflex
  • ability of non-CSCs to ‘de-differentiate’ into CSCs due to epigenetic or environmental factors, which further increases the complexity of tumour biology and treatment
  • efficacy of RAS modulators on cancer in both cancer models and cancer patients
  • A localised (‘paracrine’) RAS mechanism has been identified in many types of cancers, and interruption of the control of the RAS is thought to be the basis for its role in cancer
  • Components of the RAS are expressed by these CSCs, supporting the hypothesis of the presence of a ‘paracrine RAS’ in regulating these CSCs
  • Renin is an enzyme normally released by the kidneys in response to falling arterial pressure
  • a study of GBM demonstrating overexpression of PRR coupled with the observation that inhibition of renin reduces cellular proliferation and promotes apoptosis
  • PRR has been found to be vital for normal Wnt signalling
  • A major focus of PRR research is its relationship with Wnt signalling
  • suggest a crucial role for PRR activation on the proliferation of CSCs, possibly via Wnt/β-catenin signalling, leading to carcinogenesis.
  • Angiotensin converting enzyme (ACE), also known as CD143, is the endothelial-bound peptidase which physiologically converts ATI to ATII
  • ACE is crucial in the regulation of blood pressure, angiogenesis and inflammation
  • results suggest that an overactive ACE promotes cancer growth and progression, and an inhibited or low-activity ACE may have cancer-protective effects
  • When bound to ATII or ATIII it causes vasoconstriction by stimulating the release of vasopressin, reabsorption of water and sodium by promoting secretion of aldosterone and insulin, fibrosis, cellular growth and migration, pro-inflammation, glucose release from the liver, increased plasma triglyceride concentration, and reduced gluconeogenesis
  • ATIIR1 is a G-protein-coupled receptor, with downstream signalling involved in vasodilation, hypertrophy and NF-κB activation leading to TNF-α and PAI-1 expression
  • ATIIR1 has well-documented links with cancer, with one study demonstrating its overexpression in ~20% of breast cancer patients
  • the effect of RAS dysregulation has been associated with increased VEGF expression and angiogenesis in cancers
  • In ovarian and cervical cancer, ATIIR1 overexpression has been shown to be an indicator of tumour invasiveness
  • administration of ATIIR1 blockers (ARBs) have been associated with reduced tumour size, reduction in tumour vascularisation, lower occurrence of metastases, and lower VEGF levels
  • Nathan Goodyear on 10 Sep 18
     
    Great review on RAS in cancer.
Nathan Goodyear

Intravenous Fluids and Acute Kidney Injury - FullText - Blood Purification 2017, Vol. 4... - 1 views

www.karger.com/...452702

LR NS lactated ringers normal saline kidney

shared by Nathan Goodyear on 04 Jul 18 - No Cached
  • Nathan Goodyear on 04 Jul 18
     
    good review of LR versus NS.
Nathan Goodyear

Clinical Case Reports / Endocrine Practice - - 0 views

journals.aace.com/...EP.12.2.227

Hodgkin's lymphoma lymphoma hyercalcemia

shared by Nathan Goodyear on 17 Jan 19 - No Cached
  • Nathan Goodyear on 17 Jan 19
     
    great case study of Hypercalcemia presented with Hodgkin's. The patient was treated with IV hydration and lasix for intravascular volume depletion and kidney perfusion and to flush the calcium; prednisone and pamidronate-a bisphosphonate.
Nathan Goodyear

DISTRIBUTION OF ASCORBIC ACID, METABOLITES AND ANALOGUES IN MAN AND ANIMALS - Hornig - ... - 0 views

onlinelibrary.wiley.com/...full

vitamin C brain adrenals heart

shared by Nathan Goodyear on 28 Feb 18 - No Cached
  • Nathan Goodyear on 28 Feb 18
     
    The tissues that have the highest concentrations of vitamin C are adrenal, pituitary, brain, heart, pancrease, and kidneys.
olivehealthcare

BCG Clinic - BCG Vaccine | BCG Injection | BCG NHS - 0 views

www.olivehealthandtravel.co.uk/bcg-clinic

BCG NHS BCG Injection BCG vaccination Travel vaccinations

shared by olivehealthcare on 14 Jun 18 - No Cached
  • olivehealthcare on 14 Jun 18
     
    The BCG vaccine (which stands for Bacillus Calmette-Guérin vaccine) protects against Tuberculosis, commonly known as TB. TB is a serious infection which affects the lungs, but it can affect other parts of the body such as the bones, joints and kidneys. It can also cause meningitis.
Nathan Goodyear

Induction of Heme Oxygenase-1 and Ferritin in the Kidney in Warm Antibody Hemolytic Anemia - 0 views

www.ncbi.nlm.nih.gov/...PMC2709285

ferritin HO-1 acute kidney injury heme-oxygenate-1 AKI

shared by Nathan Goodyear on 24 May 20 - No Cached
  • Nathan Goodyear on 24 May 20
     
    induction of HO-1 induces ferritin increase to counter ROS to prolong survival. This is not a bad thing, but a survival mechanism in the short term.
indiacardiacsurg

Lifetime Monitoring After Pediatric Heart Surgery In India May Reduce Adult Hypertensio... - 0 views

www.briefingwire.com/...reduce-adult-hypertension-risk

Pediatric Cardiac Surgery In India Child Heart Treatment Pediatric Cardiac Surgery Cost Pediatric Cardiac

shared by indiacardiacsurg on 19 Mar 22 - No Cached
  • indiacardiacsurg on 19 Mar 22
     
    Other factors raising the risk of future hypertension were CHD repair surgery at age 3 months or younger, needing kidney dialysis during recovery from the low cost of pediatric cardiac surgery in India, and one or more cardiac surgeries after the initial repair.
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