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Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

  • In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
  • no relationship between LV function and biomarker levels
  • focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
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  • he cardiac impact of both acute and cumulative exercise is greatest on the RV.
  • Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
  • cardiac injury is greatest in the least trained
  • Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
  • We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
  • Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
  • The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
  • The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
  • a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
  • The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
  • BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
  • BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
  • It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
  • This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
  • Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
  • there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
  • RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
  • the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
  • focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
  • emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
  • RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
  • it is premature to conclude that these changes may represent a proarrhythmic substrate
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    Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.
Nathan Goodyear

The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glyco... - 0 views

  • Whey protein was superior to that of casein in upregulating protein synthesis
  • ability to digest more rapidly than casein protein
  • Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
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  • it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
  • The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
  • 291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
  • it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
  • Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
  • A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
  • A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
  • Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
  • adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
  • The rapid phase lasts approximately 30-60 minutes and does not require the presence of insulin
  • slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated
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    Good review of recovery supplement strategy.
Nathan Goodyear

Effects of Acute Exposure to M... [Res Sports Med. 2014 July-September] - PubMed - NCBI - 0 views

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    Article looked at the anabolic effect of low-intensity resistance exercise.  This study found a decrease in cortisol post-exercise, but no increase in anabolic effects: GH and total Testosterone.  The exercise was in untrained men, which could explain some of the decrease in the anabolic effect with the men in this study.
Nathan Goodyear

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity ex... - 0 views

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    The early post menopause phase is critical for women. This is the phase that requires intensify strategy for exercise. The ER alpha signaling is actually increased and the ability to build muscle is intensified if exercise, particularly resistance training, is employed.
Nathan Goodyear

Reversal of fatigue during prolonged exercise by carbohydrate infusion or ingestion -- ... - 0 views

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    carbohydrate intake during exercise reduces post-exercise fatigue
Nathan Goodyear

Regulation of muscle glycogen repletion, muscle, protein synthesis and repair following... - 0 views

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    Nice study and review of other studies that looked at post-exercise recovery strategies. This authors conclusion, and I concur, is that a mixture of carb 0.8 g/kg and protein 0.2 g/kg mixture immediately and 2 hours post is the best to restore glycogen stores and promote an anabolic state
Nathan Goodyear

Dehydration, rehydration, and exercise in... [Can J Appl Physiol. 1999] - PubMed - NCBI - 0 views

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    post exercise rehydration is important for adequate recovery
Nathan Goodyear

Evaluation of the antiobesity effects of an amino ... [J Int Med Res. 2010 May-Jun] - P... - 0 views

  • four amino acids (lysine, proline, alanine and arginine)
  • with or without conjugated linoleic acid to healthy overweight humans before and after exercising
  • When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo
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  • These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.
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    certain amino acids pre and post exercise help to preserve muscle mass.  This has profound implications on fat loss and maintenance of fat loss long term
Nathan Goodyear

http://www.biomed.cas.cz/physiolres/pdf/prepress/932627.pdf - 0 views

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    good discussion of the effects of resistance training on Testosterone and cortisol in obese men.  The literature is more more clear on the effects of resistance training on healthy men, but the evidence in obese men is less clear--likely due to the disrupted metabolism.
Nathan Goodyear

Thieme E-Journals - International Journal of Sports Medicine / Abstract - 0 views

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    Only abstract available here: compound resistance treaining in highly trained young men found to increase GH and Testosterone over isolation exercises. Those that trained > 2 years had significnt increase in Testosterone pre/post exercise compared to no statistical change in those traing < 2 years.
wheelchairindia9

Weight Cuff - 0 views

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    Tynor Weight Cuff Tynor Weight cuffs are used to exercise ailing joints to build strength and aid recovery. Tynor Weight Cuff is flexible and cushion, so it does not injure. Recommended for use to improve muscle tone, muscle mass, strength and stamina. Tynor Weight Cuff Features Offers 1 kg resistance when wrapped around Weight is wrapped in comfortable and soft fabric Used to build muscles, flexibility or to lose weight Can be secured easily around to prevent injuries or accidents Cuff is safe to be used during everyday activities as well Tynor Weight Cuff Measurements Sizes Available: 1/2 Kg / 1Kg / 2 Kg
Nathan Goodyear

Protein Ingestion Prior To Sleep Improv... [Med Sci Sports Exerc. 2012] - PubMed - NCBI - 0 views

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    protein intake post exercise improves recovery. In this study, they had young men take in 20 gm of protein prior to bed after resistance training at 8 pm.
Nathan Goodyear

Leucine-enriched essential amino acid supplementation during moderate steady state exer... - 0 views

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    leucine shown to increase muscle protein synthesis post exercise
Nathan Goodyear

Testosterone and cortisol in relationship to dietary nutrients and resistance exercise - 0 views

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    resistance training increases testosterone post exercise.  Dietary protein increased basal testosterone production.
Nathan Goodyear

Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after ... - 0 views

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    Leucine, a branch chain amino acid, important in promoting protein synthesis and thus muscle growth.  Very important post-exercise and in athletes
Nathan Goodyear

Effect of training status and exercise mode on endogenous steroid hormones in men - 0 views

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    decreased testosterone production/secretion in men post exercise. This was more pronounced in resistance training versus endurance training.
wheelchairindia9

Chest Binder - 0 views

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    Tynor Chest Binder Chest Binder is applied to the thoracic region to compress and bind the rib cage and provide splinting to the sternum while allowing sufficient flexibility for comfortable breathing. Anatomic chest pad. Controlled compression. Optimum chest splinting. Soft feel. Tynor Chest Binder Features 50 mm thick PUF pad hold and binds the fractured sternum without compromising on patient comfort. Strong elastic band gives good grip and helps in equidistribution of pressure. Reduces post operative pain and discomfiture. Facilitates phlegm expulsion after cardio thoracic surgery. Tynor Chest Binder Measurements Measure circumference around the chest.
Nathan Goodyear

Cambridge Journals Online - British Journal of Nutrition - Abstract - Post-exercise whe... - 0 views

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    Whey protein hydrolysate shown to be superior to amino acids in recovery phase of exercise.  
Nathan Goodyear

PLOS ONE: Alcohol Ingestion Impairs Maximal Post-Exercise Rates of Myofibrillar Protein... - 0 views

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    makes sense.  Alcohol impairs recovery from exercise--specifically protein synthesis.
Nathan Goodyear

Salivary estradiol, interleukin-6 product... [Eur J Appl Physiol. 2011] - PubMed - NCBI - 0 views

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    In this study, in addition to Estradiol, IL-6 was followed via salivary testing. This study found that post-exercise IL-6 elevation reduced energy availability from fat stores.  
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