Group items tagged

Chapter of Thyroid from oxford textbook of endocrinology and diabetes

salivary testing of cortisol proven to be a better test than blood cortisol.  Published in Clinical Endocrinology, '05.  Salivary cortisol testing is best test to evaluate cortisol levels.

hormone levels in women fluctuate.  Saliva testing used to evaluate hormone fluctuations.  Published in Journal of Endocrinology of Europe

Good discussion of the arousal/sexual response differences between men and women from a physiological perspective.  

Great, but older, discussion of aromatase link to gynecomastia in men.

Fat is a very active organ.  Increased aromatase due to cortisol.  Good review of Leptin signaling as well.  

study finds no correlation between gonadotropin levels, increasing Testosterone levels and homocysteine levels.  The treatment group had significant decline in folic acid and B12 after 6 months of treatment and this correlated with the decline in homocysteine.

Everything you wanted to know about hormones and then some.

European Journal of Endocrinology finds that salivary cortisol can be used as a diagnostic tool for Cushing's syndrome and adrenal insufficiency.  Thus both hypercortisol and hypocortisol states can be followed using saliva.  This statement was using immunoassay.  Mass spectroscopy provides even better results

European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.

salivary cortisol testing said to be "screening test of choice".  Salivary cortisol testing validated.

Individuals with ACTH secreting microadenomas have a higher incidence of hypothyroidism and should be evaluated. This only makes physiologic sense, knowing the impact on 5'deiodinase, and TSH production. Also of importance, is the methodology of cortisol evaluation.  They used salivary cortisol levels to follow.  This study was conducted at John Hopkins school of Medicine, Division of Endocrinology.  Some how others here in Louisiana have missed this (Namely LSBME and BCBS).

Good review of intra-tumor androgen synthesis from DHT metabolites.

knowledge of progesterone and its metabolites are important in the use of hormones.  As the authors concluded here: "natural steroids should not be disparaged...an update on endocrinological knowledge and experience is rather mandatory for gynecologists".  There in lies the problem.  The IOM has shown that the average physician practices at a level of 17 years behind the current scientific knowledge and the environment created by medical governing bodies discourages questions, so as to protect the system.

Testosterone therapy aids weight loss in study of obese men.  The presentation of the potentially biased study (study was funded by the makers of the Testosterone used in the study) proposes Testosterone as a pharmacologic bariatric treatment.  That conclusion is ludicrous!  Testosterone therapy has been shown to improve insulin sensitivity, improve glucose uptake, reduces inflammation, improve muscle building, and reduce the parameters of metabolic syndrome--all of which underlies the obesity.  Thus, men with low T and obesity, Testosterone therapy is playing a causal role in the obesity and thus Testosterone therapy is treating the cause.  But to describe it as pharmacologic bariatric therapy is false and misleading. http://ow.ly/CKrje 

good discussion of the estrogen metabolites and increased estrogenic activity; including cancer risk.  Particular attention is given to the 4-hydroxyestrone metabolite.

Leptin shown to inhibit steroid hormone synthesis in the gonads via inhibition of 17beta-HSD.  This is in addition to other reports of inhibition of 17,20 lyase, adrenal cortisol inhibition, inhibition of CRF, and inhibition of LH/FSH.

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women

Saliva as a medium for chronobiological studies: its particular potential in steroid endocrinology.

The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls