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Nathan Goodyear

The Role of Androgens and Estrogens on Healthy Aging and Longevity - 0 views

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    Customized hormone therapy benefits muscle and bone loss in men and women.  This is abstract only.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper11376.html - 0 views

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    Higher levels of FSH and SHBG and lower levels of free Testosterone found to be associated with bone loss in older men.
Nathan Goodyear

High aromatase activity in hypogonadal men is associated with higher spine bone mineral... - 0 views

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    Only abstract available here--high Estradiol:Testosterone, thus high aromatase activity, increased abdominal fat and reduced lean muscle mass.  The authors also reported an higher bone mineral density, but that pales in the comparison of the metabolic dysfunction of high fat and low muscle mass causes.
Nathan Goodyear

Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views

  • The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
  • Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
  • With chronic exposure over a long period of time, most absorbed lead ends up in bone
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  • The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
  • n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
  • hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.
  • Late effects may include chronic renal failure, hypertension, gout and chronic encephalopathy.6
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    occupational lead poisoning
Nathan Goodyear

Rare Occurrence of 3 "H": Hypercalcemia, Hemolytic Anemia and Hodgkin's Lymphoma - 0 views

  • administered zoledronic acid (4 mg). Prednisolone (1 mg/kg/day) was started and simultaneously, she was administered first cycle of ABVD (Adriamycin: 25 mg/m2, Bleomycin: 10 U/m2, Vinblastine: 6 mg/m2 and Dacarbazine: 375 mg/m2), which led to normalisation of serum calcium levels over 4 days and improvement in her hemoglobin levels
  • Etiology of anemia in Hodgkin’s lymphoma is multifactorial. Anemia of chronic disease, decreased red cell survival, infiltration of bone marrow by tumor and marrow suppression by chemotherapy/radiotherapy are the common mechanisms
  • Our case had only a transient response to steroids and chemotherapy. Therefore, she was treated with Rituximab which brought hemolysis under control
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  • Mechanism of hypercalcemia in HL has long been suggested to involve extra-renal activation of 1α-hydroxylase leading to production of 1, 25(OD)2 Vitamin D3 or Calcitriol, an active metabolite of Vitamin D, which leads to increased re-absorption of calcium and phosphate from intestine, increased osteoclast activation and bone resorption as well as increased phosphate re-absorption in renal tubules
  • Hypercalcemia of malignancy involves three mechanisms: 1. Humoral hypercalcemia mediated by PTHrP—seen in solid tumors like breast cancer and adult T cell leukemia/lymphoma (ATLL), 2. Direct osteoclast mediated bone resorption due to bony metastasis—seen in solid tumors and multiple myeloma, 3. Calcitriol mediated hypercalcemia—seen in Hodgkin’s and non-Hodgkin’s lymphoma as well as granulomatous disorders like tuberculosis, sarcoidosis, leprosy and disseminated Candidiasis
  • Hypercalcemia in HL is rare and its incidence has been reported as 0.9, 1.6 and 5.4 % in different series
  • The source of 1α-hydroxylase in HL has been postulated as monocytes and macrophages infiltrating the tumor akin to tuberculosis or sarcoidosis and is stimulated by IFN-γ secreted by T-lymphocytes
  • Like sarcoidosis, patients with HL exhibit increased sensitivity to Vitamin D supplements and sunlight, which have been found to precipitate hypercalcemia in these patients
  • Classical biochemical profile in Calcitriol mediated hypercalcemia include: an elevated calcium, normal/slightly elevated phosphate, normal 25(OH) Vitamin D, suppressed PTHrP and PTH, elevated Calcitriol and a normal/increased tubular reabsorption of phosphate
  • not been associated with a poorer prognosis and tends to subside after treatment of the underlying disease
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    great read on hypercalcemia in hodgkin's lymphoma.
Nathan Goodyear

Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induce... - 0 views

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    Glutamate is a growth factor for cancer.  Cells make glutamate from glutamine in the diet.  Increased glutamate is associated with cancer metastasis and increased cancer bone pain.
Nathan Goodyear

Doxycycline and other tetracyclines in the treatment of bone... : Anti-Cancer Drugs - 0 views

  • This hypothesis has now been confirmed by experimental evidence showing that doxycycline reduces tumor burden in a mouse model of breast cancer-derived osteolytic bone metastasis
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    Doxycycline inhibits MMPs, matrix metalloproteinases, and also inhibits tumor burden.
Nathan Goodyear

[Update of research on hyperthermia in relief of bone metastasis pain] - PubMed - 0 views

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    To be read
Nathan Goodyear

Hypovitaminosis D and bone mineral m... [J Clin Densitom. 2010 Oct-Dec] - PubMed - NCBI - 0 views

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    Hyperthyoid states found to be associated with low vitamin D.  The exact association is unknown.
Nathan Goodyear

The effect of short-term treatment with micronize... [Endocr Res. 2000] - PubMed - NCBI - 0 views

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    Estradiol increases SHBG in men.  This will lower the effective free levels of testosterone.  This study looked at the effect on bone turnover.
Nathan Goodyear

Asian Journal of Andrology - A role for dihydrotestosterone treatment in older men? - 0 views

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    This study shows that DHT is a good alternative androgen to Testosterone.  It was shown to have no positive/negative effect on the prostate.  The negative of this study was found to be bone loss from supra physiologic DHT.  The point there is to keep hormone replacement physiologic, as one should with all BHRT.
Nathan Goodyear

Comparison of Sex Steroid Measurements in Men by Immunoassay versus Mass Spectroscopy a... - 0 views

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    Mass Spectroscopy proves to be better test, specifically specificity, in men due to low Estradiol levels.  This study compared MS to Immunoassay.
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Plasma Total Homocysteine Level and Bone... - 0 views

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    elevated homocysteine and low folic acid levels associated with decreasing BMD in women.
Nathan Goodyear

Clinical relevance of optimizing vitamin d s... [J Spec Oper Med. 2014] - PubMed - NCBI - 0 views

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    Vitamin D has key impact in performance of soldiers.  low vitamin D has been shown to be associated with increased risk for muscle/bone injury, weakness, and poor healing.  Low vitamin D has been associated with low Testosterone.  Low vitamin D has also been associated with poor cognition, depression and less than optimal recovery after TBI.  This follows recent publication that normalization of vitamin D levels increases Testosterone levels.  
Nathan Goodyear

Vitamin D status and ill health: a systematic review : The Lancet Diabetes & Endocrinology - 0 views

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    Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.
Nathan Goodyear

Testosterone regulates bone response to inflammation. - PubMed - NCBI - 0 views

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    rat model finds low Testosterone is associated with increase inflammation.
wheelchairindia9

Cp Child Wheelchair - 0 views

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    young children have a different set of needs than adults. Aesthetically, devices designed for kids are often sleek and colorful, and functionally, they are typically lightweight and adjustable. As any parent knows, young people don't stay the same size for long and since a wheelchair is a major purchase -- don't want a simple growth spurt to render it useless. Wheelchair category offers models that feature seat width and depth adjustability, elevating legrests, and other versatile features. As a weight-bearing activity is critical to proper physical and mental function-which is why children with cerebral palsy, who may sit for stretches in a wheelchair and typically are unable to stand on their own, can benefit greatly from pediatric standers as part of a comprehensive pediatric rehabilitation program. Pediatric standers are offered in passive, active and mobile formats: Passive standers stay in one place and feature a support surface, active standers allow reciprocal movement of the extremities while in a standing position, and mobile standers enable users to self-propel. Cerebral Palsy Wheelchair: Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg. Folding action. Lever and paddle brakes provide
Nathan Goodyear

Effects of dietary calcium compared with calcium supplements on estrogen metabolism and... - 0 views

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    dietary calcium proves to be better source than Calcium supplement
Nathan Goodyear

Arch Intern Med -- Abstract: Soy Isoflavones in the Prevention of Menopausal Bone Loss ... - 0 views

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    Soy not shown to reduce menopausal symptoms in recent study
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