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Nathan Goodyear

ScienceDirect - Environmental Research : Reducing bone lead content by chelation treatm... - 0 views

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    Case study of a patient with chronic Lead exposure treated with EDTA chelation
Nathan Goodyear

Subtype-specific activation of estrogen recept... [Phytomedicine. 2007] - PubMed - NCBI - 0 views

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    Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells.  This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.
Nathan Goodyear

The association between serum dehydroepiandrosterone sulfate (DHEA-... - PubMed - NCBI - 0 views

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    Only abstract available here, but lower DHEA-S (still in reference normal range) associated with lower bone mineral density and increased osteoporosis risk.
Nathan Goodyear

Relationship of serum sex steroid levels and bone turnover markers with bone mineral de... - 0 views

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    Total Testosterone in men decreased by 30% over the lifetime of men in this study compared to 64% decrease in bioavailable Testosterone in men.  Decreased BMD was associated with this loss.  Similar findings for Estrogen was also noted in men.
Nathan Goodyear

Anemia in cancer - 0 views

  • Anemia is a frequent finding in cancer patients, occurring in >40% of cases
  • chemotherapy, the incidence of anemia may rise to 90%
  • Anemia exerts a negative influence on the quality of life
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  • Anemia has also been identified as an adverse prognostic factor
  • mild (10 g/dl—normal), moderate (8–10 g/dl), severe (6.5–8 g/dl) and life threatening (<6.5 g/dl or unstable patient) anemia
  • anemia in cancer patients is often multifactorial.
  • Cancer itself can directly cause or exacerbate anemia either by suppressing hematopoiesis through bone marrow infiltration or production of cytokines that lead to iron sequestration, or by reduced red blood cell production
  • in inflammatory anemia, iron deficiency should be defined by a low transferrin saturation of <20%, ferritin levels of <100 ng/ml and a low reticulocyte hemoglobin concentration of <32 pg
  • anemia to thrombocytosis, as commonly seen in cancer patients
  • TNF-α inhibits hemoglobin production
  • treatment itself may be a major cause of anemia
  • Other cytokines, such as interleukin-6 (IL-6), IL-1 and interferon-γ, have also been shown to inhibit erythroid precursors in vitro [9], albeit to a lesser extent
  • In inflammation, from whatever cause, IL-6 induces the liver to produce hepcidin. Hepcidin decreases iron absorption from the bowel and blocks iron utilization in the bone marrow
  • Numerous in vitro studies have illustrated the central role of TNF-α in the pathogenesis of anemia
  • nephrotoxic effects of particular cytotoxic agents such as platinum salts can also lead to the persistence of anemia through reduced Epo production by the kidney
  • Currently two options are at the disposal of the clinician for the treatment of anemia in cancer patients: transfusion of packed red blood cells and the use of erythropoiesis-stimulating agents (ESAs)
  • The goal of the treatment is to relieve the symptoms of anemia such as fatigue and dyspnea.
  • Transfusion of 1 unit of packed red blood cells has been estimated to result in an increase in the hemoglobin level of 1 g/dl in a normal-sized adult
  • a higher mortality rate in patients receiving ESA treatment
  • Recent concerns regarding the risk of thromboembolism in patients treated with ESA have been corroborated by the meta-analyses conducted by Tonnelli and Bennett
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    Great review of anemia in Cancer:  1)  blood loss 2)  increased RBC loss 3)   decreased RBC production Cancer infiltration of marrow can reduce hematopoiesis.  Inflammatory cytokines can reduce hematopoiesis.  Inflammatory cytokines can block Fe absorption.  Chemo and radiation can cause anemia--particularily platinum based therapies.
wheelchairindia9

Hip Cycle - 0 views

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    Hip Cycle is a stationary regular cycle exerciser used in physical therapy and as a sports fitness aid. Cycling is a low-impact exercise to increase muscle strength and mobility of the hips and knees. Cycling assists in hip toning by muscle growth and burning of calories. Hip Cycle Features Pedaling uses thigh muscles: quadriceps to push down, and hamstrings to pull up during the circular motion Cycling workout results in isometric engagement of the abdomen as a supporting muscle group Range of motion exercises help improve joint function Reduce hip pain caused by bone diseases such as osteoarthritis and necrosis Hip Cycle can be used in preferably recumbent position or in sitting position
wheelchairindia9

Tynor PUF Liner Skin Traction Set - 0 views

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    Tynor PUF Liner Skin Traction Set Skin traction Set (PUF liner) is used for providing indirect traction to leg or the arm to reduce fractures, skeletal deformities, muscle contractures, muscle spasms, pressure on nerves or regain normal length and alignment of involved bone. Hypoallergenic. Extra porous. Controlled adhesion and friction. Extra comfortable. Tynor PUF Liner Skin Traction Set Features Available as Complete Kit Convenient for emergencies Cost effective High performance Inbuilt cord, Quick to apply Foam liner and Bandage High performance crepe bandage for extra security Enhanced skin friction of the foam liner Easy application and removal Measure distance from knee to foot. Cut Liners for accurate use
Nathan Goodyear

https://www.nature.com/articles/6603740.pdf?origin=ppub - 0 views

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    Zometa (a bisphosophate) plus doxycycline reduce bone metastasis tumor burden on breast cancer model.
Nathan Goodyear

Waldenstroms Macroglobulinemia Patient Presenting with Rare 'lytic' Lesions and Hyperca... - 0 views

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    Interesting case study of sclerotic bone lesion in Waldenstrom's Macroglobulinemia.
Nathan Goodyear

The role of vitamin C in the treatment of pain: new insights - 0 views

  • recommended that during illness one should be careful about the intake of vitamin C, keeping in mind that acute illness rapidly depletes stores of ascorbic acid
  • it is possible that other hospital-associated pain may be partly due to vitamin C deficiency, which is relatively prevalent in hospital settings
  • Vitamin C deficiency (defined as plasma vitamin C concentrations <11 µmol/L
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  • Vitamin C is cost effective and appears to be a safe and effective adjunctive therapy for specific pain relief
  • it decreases the requirement for opioid analgesics, particularly post surgically and for bone metastasis
  • recent research has indicated a positive impact of high dose vitamin C on cancer- and chemotherapy-related quality of life, including pain
  • Cameron and Campbell [81] reported a number of cases of dramatic to complete amelioration of bone pain in patients with severe cancer-related pain given both high dose oral and intravenous vitamin C
  • hypovitaminosis C (defined as plasma vitamin C concentrations <23 µmol/L
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    vitamin C reduces pain; mechanism of action likely anti-inflammatory antioxidant, but yet inconclusive.
olivehealthcare

BCG Clinic - BCG Vaccine | BCG Injection | BCG NHS - 0 views

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    The BCG vaccine (which stands for Bacillus Calmette-Guérin vaccine) protects against Tuberculosis, commonly known as TB. TB is a serious infection which affects the lungs, but it can affect other parts of the body such as the bones, joints and kidneys. It can also cause meningitis.
Nathan Goodyear

http://cancerres.aacrjournals.org/content/canres/62/6/1588.full.pdf - 0 views

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    doxycycline to treat bone mets.
Nathan Goodyear

The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Ske... - 0 views

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    VEGF plays role in prostate cancer spread and its particular spread to and growth in bone.
Nathan Goodyear

Preliminary report on treatment of bone tumors with microwave-induced hyperthermia - Pu... - 0 views

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    To be read
krsnaphysio1

Physiotherapist in Gurgaon - 0 views

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    Since its establishment in the year 2011, Krshna Physio Plus is aimed to provide patients with comprehensive, high quality and professional physiotherapy treatments and rehabilitation to people in need. The efficient team of three, Dr. Ravi Sahauta - A very well-known complex trauma surgeon and Orthopaedician, Dr. Dharm Pal Sharma - an ex-Air force Physio trainer and Dr. Parmila Sharma - an experienced and talented physio expert, Krshna Physio Plus is counted among the well-known Physiotherapy clinic in Gurgaon and Delhi/NCR regions.  This clinic is one of the oldest organizations which was started with a vision to help people suffering from diverse dysfunctionalities with proper guidance and treatment which encompasses mainly physical, psychological, emotional, and social well being. With 8 centers in Delhi/NCR and Bihar, we are aimed at setting over 300 centers across Asia by 2020 and become the Physiotherapy clinic in Gurgaon.  Moreover, KRSNA Physio Plus is well equipped with various advanced facilities and equipment used to treat people to assure patient satisfaction and fast recovery. We have with us Top Physiotherapist in Gurgaon and Delhi/NCR regions with us who are specialized in offering treatment in physiotherapy dealing with Orthopedic, Neurological, Pediatric, Cardio-pulmonary, and Sports Injury, etc. All the experts here put their best for providing the best results.  Our experienced team of doctors and physiotherapists in Gurgaon who would be better able to diagnose what might be making it impossible for you to crane your neck, or pick articles off the floor, or simply kneel before your deity. Sports-Related Injuries Could Happen to Anyone It could be just that badminton match on a winter evening, or an office football match. Before you realize what is happening you've pulled a back muscle or your hamstring. Playing tug-of-war in colleges and office parties is fraught with the risk of a rotator cuff injury. Cricketers diving to save
finchloe121

5 Things You Need To Understand If You are Having Chronic Pain! - 0 views

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    Chronic pain is a type of pain that usually lasts for weeks to months. This pain can come and go, and it can be anywhere in the body. Chronic pain can lead to anxiety, depression, and insomnia. Chronic pain is quite different from acute pain and there are some differences between the two types. People usually experience severe pain, when it is injured by a broken bone or a cut on the skin. This pain does not last long. Pain is not something that can be ignored. If it grows, it should be fixed. As fear and pain persist, one begins to think negatively. Long-term negative thoughts begin to form in his mind, a process called fear conditioning. This factor causes an increase in blood pressure and anxiety disorders. Chronic pain is difficult to treat, and results in increased pain, fear, and negative thoughts. Extreme levels of fear lead to more pain, and the cycle of pain threats can be difficult to break. One of the best pills used to treat body pain symptoms is Hydrocodone 325mg, which you can easily buy from any trusted online pharmacy, such as Pharma Health Online.
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