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Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

birth control oral contraceptives cardiovascular risk PCOS polycystic ovary syndrome

shared by Nathan Goodyear on 28 May 13 - No Cached
  • Nathan Goodyear on 28 May 13
     
    The point of this post is not that the author concludes that metformin an statin therapy should be used in PCOS women on birth control with elevated cardiovascular risk; but that with struggling with PCOS should have cardiovascular risk assessment prior to starting birth control.  Again, back to the individualized approach paradigm.
Nathan Goodyear

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction - NEJM - 0 views

www.nejm.org/...NEJMoa055227

NORVIT trial homocysteine vitamin B12 B6 folic acid CVD cardiovascular disease MI stroke strokes events

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.
Nathan Goodyear

High total cholesterol levels in late life associated with a reduced risk of dementia - 0 views

www.neurology.org/...1689.abstract

cholesterol neurodegenerative disease dementia

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    higher cholesterol levels associated with a decreased dementia risk in the elderly population.  Stop the press!!  Yes, basic physiology tells us this. The brain loves cholesterol, cholesterol is needed. The question is: what will be the impact of "neurodegenerative diseases" by the overzealous use of statins?
Nathan Goodyear

Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unsta... - 0 views

www.lizscript.co.uk/...AMS01.pdf

cholesterol neurology brain neurodegenerative disease statins statin therapy

shared by Nathan Goodyear on 21 Jun 12 - No Cached
  • Nathan Goodyear on 21 Jun 12
     
    This article tells it all in the conclusion: "Changing our current practice pattern could take many years, but we may one day prescribe cholesterol-raising medications to certain patients". The long term effect of lowering cholesterol MAY stabilize plaques (not reduce), but at the expense of the brain. So, we may all have stable plaques, but we just won't know it because our brains will be fried.
Nathan Goodyear

Long-term Safety of Testosterone and Growth Hormone Supplementation: A Retrospective St... - 0 views

www.ncbi.nlm.nih.gov/...PMC3104655

hormones Testosterone growth GH hormone PSA cardiovascular male men

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    Retrospective study finds that 2 years of Testosterone and GH do not change metabolic biomarkers, PSA, or disease risk.  LDL and TC were in fact decreased in the study arm without statin therapy.
Nathan Goodyear

Saturated fat is not the major issue | BMJ - 0 views

www.bmj.com/bmj.f6340

saturated fats diet nutrition

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Saturated fats are not to blame.  This study debunks traditional medical dogma.  What next--statins?
Nathan Goodyear

Aged Garlic Extract Retards Progression of Coronary Artery Calcification, - J. Nutr. - 0 views

jn.nutrition.org/...741S.full

aged garlic extract plaque cardiovascular disease CVD

shared by Nathan Goodyear on 19 Feb 11 - No Cached
  • Nathan Goodyear on 19 Feb 11
     
    Amazing!  Aged garlic extract reduces plaque by 70% compared to placebo (placebo was statin + aspirin)
Nathan Goodyear

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology - 0 views

www.sciencemag.org/...1094

breast cancer cholesterol ER estrogen receptor

shared by Nathan Goodyear on 04 Jan 14 - No Cached
  • Nathan Goodyear on 04 Jan 14
     
    Study finds link between cholesterol metabolite and breast cancer.  The interesting point of this article is not that statins need to be given to all women to prevent breast cancer, which of course is what many will take.  But, that the cholesterol metabolite, 27-hydroxycholesterol showed ER agonist activity.  This would have to be ER-alpha agonist activity though the authors did not clarify.  The 27-hydroxymetabolite is created from CYP27A1.
Nathan Goodyear

The Effect of Atorvastatin and Atorvastatin-Ezetimibe Combination T... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25350347

statin therapy statins PCOS polycystic ovarian syndrome androgens Testosterone women female hormone hormones

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • Nathan Goodyear on 11 Nov 14
     
    Cholesterol lowering drug, atorvastatin, lowers androgen levels in women with PCOS.  The same has been shown in men.
Nathan Goodyear

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who... - 0 views

www.ncbi.nlm.nih.gov/...15765890

statin statin therapy diabetes

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Only abstract available here, but atorvastatin associated with a reduction in cardiovascular events but also associated with increased risk of diabetes.
Nathan Goodyear

Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 di... - 0 views

www.ajandrology.com/article.asp

Testosterone therapy diabetes lipids glucose triglycerides men male hormone hormones

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • up to 40% of men with T2DM have testosterone deficiency
  • Among diabetic patients, a reduction in sex hormone binding globulin levels induced by insulin resistance leads to a further decline of testosterone levels
  • low bioavailable testosterone concentration was related to decreased lean body mass and muscle strength
  • ...13 more annotations...
  • Testosterone deficiency has a high prevalence in men with T2DM, and it is also associated with impaired insulin sensitivity, increased percentage body fat, central obesity, dyslipidemia, hypertension and cardiovascular diseases (CVD)
  • A meta-analysis of four randomized controlled trials (RCTs) showed that TRT seemed to improve glycemic control as well as fat mass in T2DM subjects with low testosterone levels and sexual dysfunction.
  • testosterone administration could increase muscle mass and strength
  • Insulin stimulates glucose uptake into muscle and adipose tissue via the Glut4 glucose transporter isoform. When insulin activates signaling via the insulin receptor, Glut4 interacts with insulin receptor substrate 1 to initialize intracellular signaling and facilitate glucose transportation into the cell
  • The benefits of TRT on glucose metabolism can mainly be explained by its influence on the insulin signaling pathway
  • Insulin resistance as assessed by, which is calculated from the equation (If*Gf/22.5, where If is fasting insulin and Gf is fasting glucose), was definitely improved by TRT after testosterone administration in three studies
  • Testosterone was observed to elevate the expression levels and stimulate translocation of Glut4 in cultured skeletal muscle cells and to upregulate Glut4 by activating insulin receptor signaling pathways in neonatal rats
  • These effects were inhibited by a dihydrotestosterone (DHT) blocker, indicating that glucose uptake may correlate with conversion of testosterone to DHT and activation of the androgen receptor.
  • TRT reduced triglyceride levels
  • TRT has been reported to have a positive effect in the decrease of total and LDL cholesterol levels and triglycerides in hypogonadal men
  • a recent meta-analysis showed that statins could significantly lower testosterone concentrations.
  • Epidemiological studies have found a negative relationship between testosterone levels and typical cardiovascular risk markers, such as body mass index, waist circumference, visceral adiposity and carotid intima-media thickness.
  • Testosterone treatment was shown to raise hemoglobin, hematocrit and thromboxane, all of which might give rise to CVD
  • Nathan Goodyear on 17 Jan 14
     
    Low Testosterone is a very significant problem in men with type II Diabetes.  Estimated to reach 40%, likely much higher.  They based these estimates only on T levels and sexual symptoms. Testosterone improves glycemic control primarily through Increased transcription and transloction of GLUT4 insulin receptors to the cell surface.  Inflammation reduction is also a mechanism.  Testosteorne lowers Triglycerides in the traditional lipid profile.  Studies are mixed on the other aspects of  lipids.  
Nathan Goodyear

Nutrition Journal | Full text | Effects of coenzyme Q10 supplementation (300 ... - 0 views

www.nutritionj.com/...142

CoQ10 inflammation cytokines

shared by Nathan Goodyear on 19 Nov 13 - No Cached
Click Here . liked it
  • Nathan Goodyear on 19 Nov 13
     
    CoQ10 reduced inflammatory cytokines IL-6 and TNF-alpha.  CoQ10 also increased SOD, catalase, and glutathione perioxidase.  The duration of therapy was quite short--12 weeks.  The patients included in the study had pre-existing CAD.
  • Click Here . on 20 Nov 13
     
    study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!Thanks visit; blog.hoop.la
Nathan Goodyear

A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-... - 0 views

www.ncbi.nlm.nih.gov/...PMC3252497

natural cholesterol red yeast rice diet nutrition fiber niacin plant sterols

shared by Nathan Goodyear on 28 Aug 15 - No Cached
  • Nathan Goodyear on 28 Aug 15
     
    review of a few natural therapies to manage cholesterol.
Nathan Goodyear

Coenzyme Q10 in neuromuscular and neurodegenerativ... [Curr Drug Targets. 2010] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...20017723

CoQ10 Alzheimer's Parkinson's ALS Dementia Neurodegenerative disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • a deficit in CoQ10 status has been determined in a number of neuromuscular and neurodegenerative disorders
  • A secondary loss of CoQ10 status following HMG-Coa reductase inhibitor (statins) treatment has be implicated in the pathophysiology of the myotoxicity associated with this pharmacotherapy
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 contributes to neurodegenerative disease, Parkinson's, Alzheimer's, ALS..., in some
Nathan Goodyear

Arch Intern Med -- Abstract: Effect of Different Antilipidemic Agents and Diets on Mort... - 0 views

archinte.ama-assn.org/...725

Omega-3 fish oil lipids cholesterol

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Statins and n-3 fatty acids are the most favorable lipid-lowering interventions with reduced risks of overall and cardiac mortality.
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 most favorable lipid lowering agent
Nathan Goodyear

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of stat... - 0 views

www.ncbi.nlm.nih.gov/...PMC2936758

Lp(a) lipoprotein(a) cardiovascular disease risk heart health

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Lp(a) found to highly correlate with obstructive coronary disease.
Nathan Goodyear

Apolipoproteins versus lipids as indices of coronary risk and as targets for statin tre... - 0 views

www.thelancet.com/...fulltext

lipoproteins Apolipoprotein B apo B CVD cardiovascular disease risk heart health

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    apo B is a surrogate marker for LDL particle #.  However, it is an independent risk biomarker itself.
Nathan Goodyear

Lower low density lipid cholesterol levels are associated with Parkinson's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC1906875

LDL cholesterol Parkinson's Parkinson's disease statins Parkinsons disease brain health low density cholesterol

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • Nathan Goodyear on 19 Mar 15
     
    Lower LDL levels associated with increased risk of Parkinson's disease.  LDL levels < 113 were associated with a 3.5 fold increase in Parkinson's disease compared to LDL of 138.
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