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Nathan Goodyear

Molecular Neurodegeneration | Full text | alpha-Synuclein and neuronal cell death - 0 views

www.molecularneurodegeneration.com/...9

alpha synuclein Parkinsons disease neurodegeneration

shared by Nathan Goodyear on 13 Apr 11 - No Cached
  • Nathan Goodyear on 13 Apr 11
     
    alpha synuclein and Parkinsons disease
Nathan Goodyear

IOS Press - Journal Article - 0 views

iospress.metapress.com/...kj417684763h0523

Parkinson's disease mitochondrial dysfunction alpha-synuclein

shared by Nathan Goodyear on 18 Nov 11 - No Cached
  • Nathan Goodyear on 18 Nov 11
     
    study links mitochondrial dysfunction to Parkinson's disease. 
Nathan Goodyear

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Agg... - 0 views

www.nature.com/srep34477

neurodegenerative disease amyloid alzheimer's disease Parkinson's disease gut gut flora gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 06 Oct 16 - No Cached
  • Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
  • Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
  • Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
  • ...8 more annotations...
  • changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
  • Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
  • exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
  • AS aggregates seed aggregation of tau
  • involvement of the vagus nerve in PD
  • microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
  • the immune system in both AD and PD have now been extensively established
  • TLR2 activation through exposure to bacterial amyloid is pathogenic
  • Nathan Goodyear on 06 Oct 16
     
    Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease.  These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain.   More establishment of the gut-brain connection.  
Nathan Goodyear

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing ... - 0 views

www.jnutbio.com/...fulltext

mulberry mulberry fruit extract Parkinson's disease

shared by Nathan Goodyear on 23 May 17 - No Cached
  • Nathan Goodyear on 23 May 17
     
    full study of animal model that found neuroprotective effects of mulberry fruit extract in Parkinson's disease.
Nathan Goodyear

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing ... - 0 views

www.ncbi.nlm.nih.gov/...27741433

mulberry mulberry fruit extract Parkinson's disease

shared by Nathan Goodyear on 23 May 17 - No Cached
  • Nathan Goodyear on 23 May 17
     
    mulberry fruit extract found to treatment option to prevent dopaminergic damage and prevention of Parkinson's disease in animal model.
Nathan Goodyear

Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by mod... - 0 views

www.ncbi.nlm.nih.gov/...PMC7041105

BRCA curcumin

shared by Nathan Goodyear on 18 Jan 21 - No Cached
  • Nathan Goodyear on 18 Jan 21
     
    Curcumin induces BRCA re-expression in cell line study
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