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Nathan Goodyear

JAMA Network | JAMA Neurology | Beneficial Effects of Testosterone Replacement for the Nonmotor Symptoms of Parkinson Disease - 0 views

archneur.jamanetwork.com/article.aspx

testosterone therapy treatment Parkinson's parkinson's disease non motor symptoms neurology

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    Testosterone shown to provide benefit for non motor Parkinson symptoms.
Nathan Goodyear

Nicotine from edible Solanaceae and risk of Parkinson disease - Nielsen - 2013 - Annals of Neurology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...5BC47A800DBC9C1E382613A.d04t03

nicotine peppers Solanaceae Parkinson's disease Parkinson's neurology

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    Nicotine from plants like peppers found to be associated with reduced incidence of Parkinsons disease.
Nathan Goodyear

Pictorial Review of Glutamate Excitotoxicity: Fundamental Concepts for Neuroimaging - 0 views

www.ajnr.org/...1813.full

excitotoxicity Glutamate glutamic acid neurodegenerative disease Alzheimers Parkinsons ALS MS

shared by Nathan Goodyear on 13 Dec 11 - No Cached
  • Nathan Goodyear on 13 Dec 11
     
    excellent article on the imaging of excitotoxicity.  Glutamate excitotoxicity is a key component in neurodegenerative diseases: Alzheimers, Parkinsons, ALS, MS...
Nathan Goodyear

Molecular Neurodegeneration | Full text | alpha-Synuclein and neuronal cell death - 0 views

www.molecularneurodegeneration.com/...9

alpha synuclein Parkinsons disease neurodegeneration

shared by Nathan Goodyear on 13 Apr 11 - No Cached
  • Nathan Goodyear on 13 Apr 11
     
    alpha synuclein and Parkinsons disease
Nathan Goodyear

HE3286 as Treatment for Parkinson's Disease | The Michael J. Fox Foundation - 0 views

www.michaeljfox.org/...grant-detail.php

DHEA Parkinson's disease Parkinson's

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    Synthetic analogue of DHEA metabolite, HE3286, analyzed as treatment in Parkinson.s disease.
Nathan Goodyear

High doses of vitamin E in the treatment of disorders of the central nervous system in the aged - 0 views

ajcn.nutrition.org/...793.full

vitamin E Parkinson's disease Parkinson's alzheimer's disease Alzheimers alternative medicine

shared by Nathan Goodyear on 13 Jun 16 - No Cached
  • Nathan Goodyear on 13 Jun 16
     
    High dose vitamin E, in doses up to 2,000 IU, in patients with Parkinson, Alzheimers and tar dive dyskinesia found to be safe and somewhat effective in these disease states in older individuals.  The length of the studies reviewed were up to 2 years.
Nathan Goodyear

The development of mitochondrial medicine - 0 views

www.pnas.org/...8731.short

mitochondrial mitochondria disease Parkinson Alzheimer Huntington ALS

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and diabetes mellitus.
  • Nathan Goodyear on 03 Mar 11
     
    good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction
Nathan Goodyear

JAMA Network | JAMA Neurology | Refractory Nonmotor Symptoms in Male Patients With Parkinson Disease Due to Testosterone DeficiencyA Common Unrecognized Comorbidity - 0 views

archneur.jamanetwork.com/article.aspx

testosterone Parkinson's Parkinson's disease therapy low T treatment inflammation neurodegenerative disease excitotoxicity neurology male

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    Testosterone therapy aids symptoms of Parkinson's disease.  Whether low T is an associated finding or plays a role has yet to be determined.  However, we do know that androgens play an anti-inflammatory role in men and we know that inflammation plays a role in the neurodegenerative disease that is Parkinson's disease.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

www.neurology.org/...2035.abstract

pesticides disease Parkinson's Parkinson's disease solvents environmental toxins toxins paraquat

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    meta-analysis finds that exposure to pesticide and solvents increase Parkinson's disease by 80%.  One potentially problematic pesticide was paraquat.
Nathan Goodyear

LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons (S13.003) -- Kuo et al. 80 (1001): S13.003 -- Neurology - 0 views

www.neurology.org/...S13.003

Parkinsons disease neurology Lewy Bodies Chaperone-mediated autophagy

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    impaired auto destruction process leads to the Lewy bodies found in Parkinson's disease.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

www.neurology.org/...2035

pesticides Parkinson's disease PD Parkinson's disease

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Meta-analysis finds link between insecticides and Parkinson's disease.  This is not a political issue.  This is science.
Nathan Goodyear

PLOS ONE: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data - 0 views

journals.plos.org/...article

Parkinsons Parkinson's disease NAC N-acetylcysteine brain

shared by Nathan Goodyear on 17 Jun 16 - No Cached
  • Nathan Goodyear on 17 Jun 16
     
    pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud.  Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.
Nathan Goodyear

Annals of Internal Medicine | Gene-Diet Interactions in Brain Aging and Neurodegenerative Disorders - 0 views

annals.org/article.aspx

diet calorie neurodegenerative disease brain neurology parkinson's disease Alzheimer's disease aging

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • it appears that dietary restriction promotes neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins designed to promote neuronal growth and surviva
  • Studies of animal models of Alzheimer disease and Parkinson disease have shown that, by decreasing homocysteine levels, dietary folic acid can be neuroprotective
  • The current average daily calorie intake of Americans is approximately 2700 for women and more than 3000 for men
  • Nathan Goodyear on 25 Jun 12
     
    what you eat and how many calories you eat effects you brain and your risk of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.
Nathan Goodyear

Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study - 0 views

www.direct-ms.org/...s%20and%20ketagenic%20diet.pdf

hyperketogenic diet parkinson's disease PD parkinson's ketones

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Hyperketogenic diet shown to provide many therapeutic benefits in other disease states. This study, though very small, showed that symptoms did improve with a hyperketonemic diet. This was a feasibility study.
Nathan Goodyear

Glutathione and Parkinson's Disease - ACAM Integrative Medicine (IM) Blog - 0 views

acam.typepad.com/...ne-and-parkinsons-disease.html

IV glutathione Parkinson's disease treatment therapy

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    IV glutathione therapy as adjuvant in people with Parkinson's disease
Nathan Goodyear

Astrocytes and therapeutics for Parkinson'... [Neurotherapeutics. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20880505

Astrocytes neurodegenerative disorders disease Parkinson's ALS

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    astrocytes play role in neurodegenerative disorders.
Nathan Goodyear

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007 - Annals of Neurology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

TCE environmental toxins mitochondria Parkinson's Disease PD

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    TCE shown to mitochondrial toxic and risk factor for Parkinson's disease
Nathan Goodyear

Risk of Parkinson Disease Onset in Patients With Diabetes - 0 views

care.diabetesjournals.org/...1047.abstract

diabetes parkinson's disease neurodegenerative disease

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    Diabetes associated with an increased risk of Parkinson's disease in young men, middle aged women, and the elderly.
Nathan Goodyear

Unrecognized vitamin D3 deficiency is common in Parkinson disease - 0 views

www.neurology.org/...WNL.0b013e3182a95818.abstract

vitamin d deficiency Parkinson's disease

shared by Nathan Goodyear on 30 Sep 13 - No Cached
  • Nathan Goodyear on 30 Sep 13
     
    low Vitamin D associated with Parkinson's disease
Nathan Goodyear

Oxidative stress, mitochondrial dysfunction and ce... [J Neurol Sci. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15896810

CoQ10 mitochondria neurodegenerative disease Alzheimer's Parkinsons MS ALS oxidative stress

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple sclerosis and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) associated with mitochondrial dysfunction
  • Nathan Goodyear on 07 Feb 11
     
    Mitochondrial dysfunction at heart of diseases such as Parkinson's, Alzheimers, MS, ALS..
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