excellent article on the imaging of excitotoxicity. Glutamate excitotoxicity is a key component in neurodegenerative diseases: Alzheimers, Parkinsons, ALS, MS...
High dose vitamin E, in doses up to 2,000 IU, in patients with Parkinson, Alzheimers and tar dive dyskinesia found to be safe and somewhat effective in these disease states in older individuals. The length of the studies reviewed were up to 2 years.
n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired
oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such
as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and
diabetes mellitus.
Testosterone therapy aids symptoms of Parkinson's disease. Whether low T is an associated finding or plays a role has yet to be determined. However, we do know that androgens play an anti-inflammatory role in men and we know that inflammation plays a role in the neurodegenerative disease that is Parkinson's disease.
pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud. Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.
it appears that dietary restriction promotes neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins designed to promote neuronal growth and surviva
Studies of animal models of Alzheimer disease and Parkinson disease have shown that, by decreasing homocysteine levels, dietary folic acid can be neuroprotective
The current average daily calorie intake of Americans is approximately 2700 for women and more than 3000 for men
Hyperketogenic diet shown to provide many therapeutic benefits in other disease states. This study, though very small, showed that symptoms did improve with a hyperketonemic diet. This was a feasibility study.
There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple sclerosis and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) associated with mitochondrial dysfunction