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Nathan Goodyear

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced d... - 0 views

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    decreased bifidobacterium gut flora results in increased absorption of LPS in high fat diets resulting in endotoxemia. This plays a significant role in diabetes
Nathan Goodyear

The gut-liver-axis: Endotoxemia, inflammation, insulin resistance and NASH - 0 views

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    metabolic endotoxemia starts with what you eat.  Chronic over nutrition results in elevated LPS. This starts a cascade of events that results in inflammation.  A well balanced gut flora of bifidobacterium is one way to slow this trigger.
Nathan Goodyear

Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopoly... - 0 views

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    cordyceps shown to decrease LPS stimulated macrophage inflammation.  Specifically, IL-1Beta, IL-6, TNF-alpha were shown to be inhibited.  Also, NF-kappaB inhibition was found with cordyceps
Nathan Goodyear

Histochemistry and Cell Biology, Volume 127, Number 2 - SpringerLink - 0 views

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    Abstract only, but this study shows that the innate immunity plays a role in the development of obesity through the TLR.  LPS was shown to stimulate the inflammatory cascade through the TLRs
Nathan Goodyear

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in... - 0 views

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    proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade.  This plays a key role in the obesity epidemic.
Nathan Goodyear

Figure 2 : Targeting gut microbiota in obesity: effects of prebiotics and pro... - 0 views

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    nice diagram of proposed mechanism of how diet and gut microbiota can influence the production of PPAR-gamma inducing growth of adipose tissue.  Also proposes how LPS and the endocannabinoid system contributed to a leaky gut and thus the proposed "metabolic endotoxemia"
Nathan Goodyear

Hypocortisolism and increased glucocorticoid... [Biol Psychiatry. 2004] - PubMed - NCBI - 0 views

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    low cortisol and elevated LPS, IL-6, and TNF-alpha found in people with PTSD.
Nathan Goodyear

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: ... - 0 views

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    Dysfunctions of the innate immune system, in the gastrointestinal system, in children with autism found. LPS found to be involved. Again, revealing a gut-brain connection in autism.
Nathan Goodyear

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fa... - 0 views

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    2008 article from diabetes.  This article supports metabolic endotoxemia arising out of the gut.  High fat diet intake results in disrupted gut flora, resulting in increrased LPS release, resulting in inflammation, leads to leaky gut, systemic endotoxemia, inflammation, and thus metabolic dysfunction: see obesity, DM..
Nathan Goodyear

Endotoxemia-induced inflammation and the effect on... [Crit Care. 2010] - PubMed - NCBI - 0 views

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    LPS endotoxemia shown to induce brain inflammation.  In this study, the inflammatory cytokine upregulation did not fully explain the septic encephalopathy so often found.  It was associated with elevated cortisol, which has been shown to shrink the hippocampus
Nathan Goodyear

Inflammation-induced vasoconstrictorhyporeactivity is caused by oxidative stress -- Ple... - 0 views

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    IV vitamin C shown to reduce the inflammatory associated complications (vasoconstriction, HTN...) found due to LPS in E. Coli endotoxemia
Nathan Goodyear

Anti-inflammatory effect of proteoglyca - PubMed Mobile - 0 views

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    progesterone inhibits LPS stimulated inflammation.  Progesterone actually inhibits TLR4 activation.  The statement that progesterone has no place in hormone therapy is both uneducated and uninformed.
Nathan Goodyear

Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotei... - 0 views

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    LPS and minimal oxidized LDL have synergistic effects on inflammatory signaling.  Together the two promote inflammatory signaling from macrophages at much lower levels than either one alone.  They do this through macrophage NF-KappaB and AP-1 pathways.  And this resultant inflammation promotes atherosclerosis.  Where does all this start?  our diet and our gut.
Nathan Goodyear

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Re... - 0 views

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    LPS linked to dsylipidemia, insulin resistance, obesity, and chronic inflammation.
Nathan Goodyear

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Ins... - 0 views

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    HFD and LPS endotoxin induce inflammation through TLR-4 to increase insulin resistance and obesity.
Nathan Goodyear

Mortality of Candida albicans-infected mice is ... [J Infect Dis. 1995] - PubMed - NCBI - 0 views

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    LPS from gram negative E. coli worsens negative effects of Candida albicans on mice cells.
Nathan Goodyear

Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX... - 0 views

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    essential oils inhibit LPS induced COX-2 activity.
Nathan Goodyear

http://eurheartj.oxfordjournals.org/content/26/16/1633.full.pdf - 0 views

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    Lp(a) associated with increased risk at levels > 30 in women.  The risk is double.
Nathan Goodyear

Abstract 3608: Lipoprotein (a) Cholesterol, But Not Lp(a) Mass, Is An Independent Predi... - 0 views

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    Lipoprotein (a) cholesterol is a better predictor of CAD and CVD events than Lipoprotein (a) mass.
Nathan Goodyear

Lipoprotein(a) Mass: A Massively Misunderstood Metric - Journal of Clinical Lipidology - 0 views

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    Lp(a), especially the particle #, is highly associated with increased cardiovascular risk.
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