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Nathan Goodyear

Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Dis... - 0 views

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    Testosterone therapy, injected intracoronary, resulted in vasodilation and improved blood flow in men with CAD.
Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
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  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
Nathan Goodyear

Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal... - 0 views

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    Prospective study finds that elevated total and free Estradiol levels in the follicular phase and elevated total and free Testosterone levels in both the follicular and luteal phase are associated with increased breast cancer in women.  The risk is for pre menopause in this study.  This and several other studies point to serious questions about the massive dosing of Testosterone via pellets, injections, and topicals for libido.  We appear to be following the same patter as seen with premarin, provera, now Testosterone in men and this may be the next ball to drop.  Is the Testosterone therapy merely producing an environment that feeds breast cancer?
Nathan Goodyear

The effect of human chorionic gonadotropin-based h... [Andrology. 2013] - PubMed - NCBI - 0 views

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    HCG injections useful in raising intra-testicular testosterone levels and aiding sperm production in those with azoospermia.
Nathan Goodyear

Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments b... - 0 views

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    Rat model induced inflammatory reaction in brain via LPS injection.  The result was impaired memory.  RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
Nathan Goodyear

Macrophagic myofasciitis: characterization and pathophysiology - 0 views

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    Aluminum in vaccines shown to stimulate a massive autoimmune reaction.  These reactions can be localized or distant from site of injection.  Accumulation occurs in the brain and CNS.  The name give is macrophagic myofasciitis.
Nathan Goodyear

Arch Intern Med -- Abstract: Human Chorionic Gonadotropin (HCG) Treatment of Obesity, F... - 0 views

  • hese results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss.
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    HCG injections appear to have no effect on weight loss over those following 500 cal diets
Nathan Goodyear

Chorionic Gonadotropin in Weight Control, November 29, 1976, Young et al. 236 (22): 249... - 0 views

  • here was no statistically significant difference between those receiving HCG vs placebo during any phase of this study
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    NO difference in weight loss in those receiving HCG injections
Nathan Goodyear

Human chorionic gonadotrophin and weight loss. A d... [S Afr Med J. 1990] - PubMed result - 0 views

  • Subjects receiving HCG injections showed no advantages over those on placebo in respect of any of the variables recorded.
  • weight loss on our diet was similar to that on severely restricted intake
  • We conclude that there is no rationale for the use of HCG injections in the treatment of obesity.
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    HCG versus diet alone shows no difference in weight loss
Nathan Goodyear

Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study - 0 views

  • There was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings
  • HCG does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction.
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    HCG ineffective in weight loss in a double-blinded study
Nathan Goodyear

[Hyperandrogenism or insulin resistance. What... [Lakartidningen. 1993] - PubMed - NCBI - 0 views

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    This study shows that induced hyperandrogenism in women causes insulin resistance.  This should be taken well note of by many physicians and patient.  Many women are prescribed massive amounts of testosterone through pills or injections, which is likely contributing to weight increase.  
Nathan Goodyear

Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor,... - 0 views

  • the MAF precursor activity of prostate cancer patient Gc protein is lost or reduced, because their serum Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells
  • Administration of 100 ng of GcMAF
  • 100 ng of GcMAF was administered intramuscularly once a week
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  • As GcMAF therapy progressed the MAF precursor activity of all five patients increased and their serum Nagalase activity decreased inversely
  • As GcMAF therapy progressed, the MAF precursor activity increased with a concomitant decrease in serum Nagalase activity
  • serum Nagalase is proportional to tumor burden
  • as GcMAF therapy progressed, serum Nagalase activity decreased and, concomitantly, tumor burden decreased
  • the serum Nagalase activities of all 16 patients decreased as GcMAF therapy progressed
  • annual computed tomographic scans of these patients confirmed them being tumor recurrence-free for the 7 years
  • undifferentiated cells were killed rapidly during the first few weeks, and the differentiated cells were killed slowly in the remaining GcMAF therapeutic period
  • PSA levels of prostatectomized patients decreased as serum Nagalase decreased during GcMAF therapy
  • In patients without tumor resection, however, although serum Nagalase activity decreased as GcMAF therapy progressed, their PSA values remained unchanged. The result suggests that the PSA derived from tumor-bearing prostate did not change while tumor burden decreased. Because tumor-induced inflammation in the noncancerous prostate tissues causes secretion of PSA [38], the PSA produced from these inflamed noncancerous prostate tissues cannot be changed by the decrease in tumor burden
  • Advanced cancer patients have high serum Nagalase activities, resulting in no macrophage activation and severe immunosuppression that explain why cancer patients die with overwhelming infection
  • Prognostic utility of serum α-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients
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    GC-MAF levels exist in inverse relationship to nagalase.  In this study of men with prostate cancer, weekly GCMAF injections reduced Nagalase activity to levels found in healthy controls suggesting tumor free. The dose was 100 ng/week. Nagalase is a protein that suppresses GC-MAF production and thus is immunosuppressive.
Nathan Goodyear

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11... - 0 views

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    animal study finds LPS, via injection in this mouse study, increases atherosclerosis via increased .  What is very interesting is that Boswellia inhibited LPS stimulate NF-kappa B
Nathan Goodyear

Antitumor effect of avermectins. - PubMed - NCBI - 0 views

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    Ivermectin shown to inhibit tumor growth by up to 80% after intraperitoneal injection.  This effect was found following the administration of vincristine.
fnfdoc

How Bad Vitamin B12 Deficiency | Your Health Our Priority - 0 views

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    Vitamin b12 called cobalamine, important for vital functions in body, like maintenance. Deficiency cause malnutrition and digestion problems. Treatments including supplements, injections and vitamins regulatory measures.
Nathan Goodyear

[Antitumor effect in mice of an organic germanium compound (Ge-132) when different admi... - 0 views

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    IV germanium augments NK activity in mouse blood providing anti-tumor activity.  Different activity found with po and intra-peritoneal injection--augmentation of cytotoxic macrophages.  Prolongation of life was not found in the IV arm.
olivehealthcare

BCG Clinic - BCG Vaccine | BCG Injection | BCG NHS - 0 views

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    The BCG vaccine (which stands for Bacillus Calmette-Guérin vaccine) protects against Tuberculosis, commonly known as TB. TB is a serious infection which affects the lungs, but it can affect other parts of the body such as the bones, joints and kidneys. It can also cause meningitis.
olivehealthcare

Olive Health & London Travel Clinic | Blood Tests | Private BCG London - 0 views

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    Olive health & travel clinic ilford, London provide quality medical services in different fields like Private BCG london, Slimming jab, InterVax, Mobile phlebotomy, BCG NHS, Umrah vaccination, Ear irrigation, Hajj vaccination, BCG Injection. We also provide Travel vaccinations and antimalarials, Health Immunisations such as BCG, Shingles, HPV, Meningitis, Hepatitis B etc., Blood tests, Mobile phlebotomy (blood tests at home), Ear wax removal by irrigation method, Weight loss clinic (Saxenda), DNA/Paternity tests, and a range of health checks including STI testing.
trungtamnamkhoa

Pharma Injectable Sust 250mg of the faculty Men's Health - 1 views

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    Pharma Sust 250mg injections treat hypogonadism disorders in men, after the illness, impotence due to lack of hormones, menstrual symptoms in men such as reducing sexual pleasure and physiological activities. Side effects: The drug can cause erectile dysfunction, signs of excessive sexual stimulation, reduced sperm count, decreased volume of ejaculation, water & salt retention. In pre-puberty boys: develop sex early, increase the frequency of erectile dysfunction, enlargement of the penis, and early growth of bone heads.
Nathan Goodyear

Diabetes Care - 0 views

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    contraceptive patch and progestin injectable contraception associated with highest risk of thromboembolism in women with diabetes.
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