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Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.full

low T3 syndrome T4 TSH CVD cardiac hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    low T3, not T4 or TSH, found to be associated with a strong predictor of death in cardiac patients.  This also has implications in predicting outcome in cardiac patients.
Nathan Goodyear

Thyroid function and thyroid hormone metabol... [Klin Wochenschr. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7241955

hypothyroid hypothyroidism TSH T3 syndrome low aging thyroid hormone

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    This study doesn't find evidence of low t3-syndrome, but suggests the impairment of TSH secretion (low TSH)is the first potential sign of thyroid dysfunction.
Nathan Goodyear

Prevalence of Neuroendocrine Dysfunction in Patients Recovering from Traumatic Brain In... - 0 views

jcem.endojournals.org/...2752.full

TBI traumatic brain injury HGH pituitary cortisol thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    TBI results in pituitary dysfunction.  The result in low cortisol, low thyroid, and low HGH.  Other hormones appeared to be unaffected
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.short

T3 low hypothyroid hypothyroidism cardiac CHF

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    low T3 is found to be a poor prognostic finding in cardiac patients.
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

www.ajconline.org/...abstract

CHF T3 hypothyroid hypothyroidism heart failure

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure: The C... - 0 views

www.sciencedirect.com/...S0735109708024029

heart failure CHF TSH hypothyroid hypothyroidism

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    increased risk of heart failure found in patients with TSH > 10.
Nathan Goodyear

Regulation of 11beta-HSD genes in human adipose tis... [Obes Res. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14742837

stress cortisol cortisone obesity fat cells adipocytes adipose tissue

shared by Nathan Goodyear on 09 Mar 12 - No Cached
  • Nathan Goodyear on 09 Mar 12
     
    adipocytes increase genetic expression of 11beta-HSD. This increases local cortisol production from cortisone.  This plays a pivotal role in obesity.  Question:  would this play a role in peripheral hypothyroid?  I think so.
Nathan Goodyear

Effects of selective serotonin reuptake inhibitors o... [Thyroid. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19583486

thyroid SSRI antidepressants

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Interesting study.  They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid.   The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.
Nathan Goodyear

Combination L-T3 and L-T4... [Curr Opin Endocrinol Diabetes Obes. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23974776

hypothyroid hypothyroidism T4 T3 thyroid therapy

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    This article reviews the genetic polymorphisms that play role in low T4 to T3 conversion and thus combination T4/T3 therapy is indicated.  This study fails to recognize the environmental impacts on the deiodinase enzymes.
Nathan Goodyear

Assessment of thyroid function during ... [Clin Endocrinol (Oxf). 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19094075

Hashimoto's thyroiditis hypothyroid hypothyroidism autoimmune disease thyroid hormone hormones inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's Thyroiditis can show variability in thyroid function.
Nathan Goodyear

Racial and age-related differences in incid... [Am J Clin Pathol. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8209854

Hashimoto's thyroiditis hypothyroid hypothyroidism thyroid autoimmune disease inflammation hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's thyroiditis is more common in white females.
Nathan Goodyear

Thyroid Function Tests and Mortality in Aged Hospitalized Patients: A 7-Year Prospectiv... - 0 views

jcem.endojournals.org/...4683.abstract

free T3 fT3 hypothyroid hypothyroidism T3 mortality cardiovascular disease thyroid function

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    Here is an interesting finding:  low free T3 is significantly associated with increased cardiovascular and all-cause mortality in 7 prospective study on hospitalized patients.
Nathan Goodyear

Celiac Disease and Autoimmune Thyroid Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2111403

autoimmune thyroid disease hypothyroidism hypothyroid TPO gluten sensitivity gluten celiac disease celiac

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    increased incidence of autoimmune thyroid disease and celiac disease or gluten sensitivity.
Nathan Goodyear

Subclinical hypothyroidism ... [Eur J Obstet Gynecol Reprod Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24768234

LDL cholesterol lipids PCOS polycystic ovarian syndrome TSH thyroid hypothyroid women female hormone hormones

shared by Nathan Goodyear on 14 May 14 - No Cached
  • Nathan Goodyear on 14 May 14
     
    Women with PCOS need a closer follow of their thyroid function.  TSH positively correlated with increasing LDL.
Nathan Goodyear

Relative vitamin D insufficiency in Hashimoto's thyr... [Thyroid. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21751884

vitamin D vitamin D Hashimoto's thyroiditis hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    low vitamin D levels associated with Hashimoto's thyroiditis.
Nathan Goodyear

Proinflammatory cytokines inhibit the expre... [Eur J Endocrinol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11916626

inflammation cytokines cytokine IL-1beta IL-6 TNF-alpha thyroid hypothyroid hypothyroidism deiodinase

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    inflammatory cytokine IL-1beta reduced deiodinase transcription, thus reducing T4 to T3 conversion.  The inflammatory cytokines TNF-alpha and IL-6 did also but to a lesser degree.
Nathan Goodyear

Potential uses of T3 in the treatment of human dis... [Clin Cornerstone. 2005] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...16399246

T3 hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • riiodothyronine (T3), formed by the monodeiodination of T4, is the biologically active form of thyroid hormone
  • Nathan Goodyear on 01 Feb 11
     
    T3 is the active, biologically form of the thyroid hormone
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.long

T3 low T3 cardiac heart disease CVD cardiovascular thyroid hormone hormones hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
  • Nathan Goodyear on 03 Jul 12
     
    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
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