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Nathan Goodyear

The effects of repeated thermal ther... [J Altern Complement Med. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20569036

IR sauna diabetes DM type II QOL

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IR sauna improves quality of life measures in patients with type II diabetes
Nathan Goodyear

GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin... - 0 views

www.ncbi.nlm.nih.gov/...PMC2956412

Omega-3 n-3 DHA EPA inflammation insulin diabetes DM GPR120 receptor cytokines

shared by Nathan Goodyear on 16 Jul 12 - No Cached
  • Nathan Goodyear on 16 Jul 12
     
    Omega-3, DHA and EPA, exert anti-inflammatory effects through GPR120 receptor.  This improved insulin sensitivity and had diabetes effects in-vivo model.  The effect was through the reduction of macrophage-induced inflammatory cytokines.
Nathan Goodyear

Alpha-lipoic acid in the treatm... [Exp Clin Endocrinol Diabetes. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10595592

alpha-lipoic-acid LA alpha lipoic acid diabetic neuropathyType II DM diabetes

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    alpha lipoic acid shown to reduce diabetic neuropathy in this review of 15 clinical trials.  The trials included both IV and oral administration of alpha lipoic acid.  Both routes of administration revealed positive reduction of neuropathic symptoms.
Nathan Goodyear

Arch Intern Med -- Abstract: Statin Use and Risk of Diabetes Mellitus in Postmenopausal... - 0 views

archinte.ama-assn.org/...144

Statin statins type II 2 diabetes DM postmenopausal women

shared by Nathan Goodyear on 28 Feb 12 - No Cached
  • Nathan Goodyear on 28 Feb 12
     
    Statin drugs shown to increase risk of Diabetes in postmenopausal women
Nathan Goodyear

Obesity, Diabetes, and Gut Microbiota - 0 views

care.diabetesjournals.org/...2277.long

gut microbiota dysbiosis overweight obesity diabetes DM

shared by Nathan Goodyear on 01 Mar 12 - No Cached
  • Nathan Goodyear on 01 Mar 12
     
    the gut microbiota can alter energy  homeostasis, resulting in obesity and diabetes
Nathan Goodyear

Predictive parameters of accelerated muscle loss in... [Am J Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24524994

muscle Total Testosterone free T type II diabetes type II DM parathyroid PTH

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Study looked at muscle loss in older men and found that low activity, type II diabetes, low Total Testosterone and low free Testosterone, and increased PTH are associated with an increased muscle loss 
Nathan Goodyear

Singapore Medical Association (SMA) - Formed in 1959, the Singapore Medical Association... - 0 views

sma.org.sg/...articles.aspx

type II diabetes Diabetes DM omega 3 EPA HbA1C HgbA1C insulin sensitivity insulin resistance insulin

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Omega 3 associated with improved insulin sensitivity, reduced HbA1C, reduced fasting glucose.  This study looked at the specific effect of EPA in those with type II diabetes
Nathan Goodyear

Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systema... - 0 views

care.diabetesjournals.org/...569.abstract

coffee diabetes type II diabetes type II DM polyphenol

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Coffee, whether caffeinated or decaffeinated, is found to reduce the risk of type II diabetes in meta-analysis.  According to the authors, it is the polyphenols that provide the benefits.
Nathan Goodyear

Effect of Nigella sativa seeds on the glycemic con... [Indian J Physiol Pharmacol. 2010... - 0 views

www.ncbi.nlm.nih.gov/...21675032

Nigella Sativa herb herbs spice diabetes DM

shared by Nathan Goodyear on 17 Aug 11 - No Cached
  • Nathan Goodyear on 17 Aug 11
     
    Nigella sativa, spice, shown to improve blood sugar control in Type II Diabetes
Nathan Goodyear

The In Vivo Antidiabetic Activity of Nigella sativ... [Evid Based Complement Alternat M... - 0 views

www.ncbi.nlm.nih.gov/...21584245

Nigella Sativa cumin herb herbs spice glucose Diabetes DM cholesterol HDL

shared by Nathan Goodyear on 17 Aug 11 - No Cached
  • Nathan Goodyear on 17 Aug 11
     
    Nigella Sativa, the spice cumin, is found to lower glucose and raise HDL cholesterol
Nathan Goodyear

Mary Ann Liebert, Inc. - Diabetes Technology & Therapeutics - 2(3):401 - 0 views

www.liebertonline.com/...15209150050194279

alpha-lipoic-acid insulin sensitivity resistance Type II Diabetes DM

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    alpha lipoic acid improves insulin sensitivity in patients with type II Diabetes
Nathan Goodyear

A current update on ... [Endocr Metab Immune Disord Drug Targets. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19601918

alpha-lipoic-acid type II 2 Diabetes DM

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    alpha-lipoic-acid improves diabetes control and reduces complications
Nathan Goodyear

Vitamin D deficiency and insulin ... [J Pediatr Endocrinol Metab. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21528812

vitamin vitamin d insulin resistance diabetes DM obesity overweight adiponectin

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    vitamin D associated with low adiponectin, obesity and insulin resistance in african Americans
Nathan Goodyear

Urinary glucose and vitamin C. [Am J Clin Pathol. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...920657

Vitamin C DM diabetes

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • vitamin C added, false-positive tests for glucose were found
  • Nathan Goodyear on 13 Jul 11
     
    high dose vitamin C causes false positive glucose elevations
Nathan Goodyear

Alt/Trad Medical Review - 0 views

www.mountainmistbotanicals.com/..._Interactions_Interference.htm

Vitamin C glucose DM diabetes

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • Vitamin C interferes with several glucose tests, including tests diabetics use at home. U
  • rinary glucose test strips will test false positive with as little as 2,000mg of vitamin C daily
  • Nathan Goodyear on 13 Jul 11
     
    Vitamin C will induce false positives on glucose test strips
Nathan Goodyear

Prevalence of Low Testosterone and Predisposing Risk Factors in Men With Type 1 Diabete... - 0 views

press.endocrine.org/...jc.2014-1317

type I DM type I diabetes free Testosterone Testosterone obesity age SHBG insulin men male hormone hormones diabetes

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Study of men with type I Diabetes finds no significant increase in association with low T. What they did find was an association with obesity, age, and decreased SHBG.   Increasing insulin dosage was associated with lower "calculated" free Testosterone--this is something that should be explored further.  
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

www.ajandrology.com/article.asp

Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and Metabolic Syndrome.
tom cruze

Clinical Trial Data Management Ensuring regulation and accuracy of clinical trial data | - 0 views

blog.worksure.org/clinical-trial-data-management

Clinical Trial Data Management

shared by tom cruze on 25 Feb 15 - No Cached
  • tom cruze on 25 Feb 15
     
    The data management of a clinical trial is a crucial step for the firms that are undergoing research studies in the hospitals. Maintaining the quality and integrity of clinical data is yet another daring task to perform. Many of recent studies showed numerous troubles with data management system (DMS) in clinical trials performed at academic organizations.
Nathan Goodyear

Evolving landscape of human epidermal growth factor receptor 2-positive breast cancer t... - 0 views

www.sciencedirect.com/...S0960977617300103

HER-2 breast cancer cancer herceptin Perjeta

shared by Nathan Goodyear on 06 Aug 18 - No Cached
  • 15%–20%
  • key mediator of cell growth, differentiation, and survival
  • of higher histological grade and are more likely to invade axillary lymph nodes
  • ...15 more annotations...
  • shortened survival and an increased risk of disease recurrence and metastasis
  • Currently, four HER2-directed agents are approved for the treatment of patients with HER2+ breast cancer: trastuzumab, pertuzumab, lapatinib, and ado-trastuzumab emtansine (T-DM1)
  • biosimilars
  • trastuzumab may provide greater benefit when administered concurrently with chemotherapy rather than after, and this has become the standard approach
  • concurrent use of anthracyclines (ie, doxorubicin or epirubicin) and trastuzumab is not recommended because of an increased risk for cardiac toxicity
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      avoid herceptin in conjuction with antracyclines i.e. doxorubicin
  • Sequential doxorubicin plus cyclophosphamide followed by concomitant paclitaxel or docetaxel and trastuzumab is recommended for most patients
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      top recommended regimen combination
  • Guidelines also recommend trastuzumab in combination with paclitaxel, docetaxel and carboplatin, or docetaxel and cyclophosphamide, particularly for patients with increased risk for cardiac toxicity or those with small (≤1 cm), node-negative HER2+ tumors
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      good alternative in patients with increased risk of cardiac toxicity.
  • guidelines recommend up to 1 year of adjuvant trastuzumab
  • Neoadjuvant chemotherapy with trastuzumab is associated with higher rates of pathologic complete response (pCR) than chemotherapy alone or in combination with lapatinib
  • the combination of trastuzumab, lapatinib, and chemotherapy is not recommended because it failed to demonstrate noninferiority versus trastuzumab and chemotherapy in the adjuvant setting
  • recommend the combination of trastuzumab, pertuzumab, and chemotherapy as neoadjuvant treatment for patients with locally advanced HER2+ breast cancer and for some patients (node-positive or tumor ≥2 cm) with early-stage disease
  • neoadjuvant chemotherapy in combination with pertuzumab and trastuzumab reduced the risk of progression or death by 31% and recurrence or death by 40% versus trastuzumab alone
  • Concurrent chemotherapy and HER2-directed therapy improves survival outcomes over chemotherapy alon
  • dual inhibition of HER2 with trastuzumab and pertuzumab in combination with paclitaxel reduced the risk of death or progression by approximately 40% compared with concurrent trastuzumab and paclitaxel
  • the combination of trastuzumab, pertuzumab, and taxane chemotherapy is the preferred first-line regimen
  • Nathan Goodyear on 06 Aug 18
     
    HER-2 + breast cancer = appx 15-20% of all breast cancers and is a marker of worse prognosis and an indication for targeted immunotherapy blockade.
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