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Nathan Goodyear

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients ... - 0 views

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    This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke... - 0 views

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    Lower DHEAS in women (25 percentile) in this study associated with increased risk of stroke.  
Nathan Goodyear

Run for your life … at a comfortable speed and not too far -- O'Keefe and Lav... - 0 views

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    Running beyond 25 miles weekly is damaging to the heart according to this editorial.  
Nathan Goodyear

Human semen quality in the new millennium: a prospective cross-sectional popu... - 0 views

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    2012 study that shows a slight uptick in sperm count/concentration in Danish men.  However, as the conclusion states, on 25% have optimal sperm quality.  When you look at the numbers deeper, the current general population sperm count/concentration was lower than that of men of infertile couples from 1940-1943 cohort.  Additionally, when the general population sperm count/concentration was lower than that of compared recent fertile men.
Nathan Goodyear

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Reprod... - 0 views

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    Testosterone has moved from therapy to recreational for many men.  The 50-25-21 rule.
Nathan Goodyear

http://iai.asm.org/content/early/2011/04/25/IAI.00076-11.full.pdf - 0 views

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    Estradiol and progesterone inhibit TNF-alpha and IL-6.
Nathan Goodyear

JAMA Network | JAMA | Vaccinated Populations Can Get Flu - 0 views

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    startling study of poor prevention of flu vaccine in US navy; mandatory vaccine in US navy, yet 25 developed flu, with 18 matching the strain in vaccine.
Nathan Goodyear

Testosterone decreases after ingestion of sugar (glucose) | Endocrine Society - 0 views

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    sugar intake can decrease Testosterone levels by as much as 25% in men.
Nathan Goodyear

Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of... - 0 views

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    Bulbine natalensis (Baker) stem found to be useful in libido/ED at doses of 25-50 mg/kg in animal studies.
Nathan Goodyear

Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats: Phar... - 0 views

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    Bulbine natalensis Baker stem found to increase Testosterone by up to 350% in animal studies in 2 weeks.  The dose with the optimum response was 25 and 50 mg/kg, with the most best effect at 50 mg/kg.  LH and FSH production was increase but exact mechanism not discussed.  Only abstract available here.
Nathan Goodyear

Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino... - 0 views

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    Bulbine natalensis Baker stem extract found to increase LH and Testosterone in wistar rats in 7 days at doses of 25 to 50 mg/kg; this effect was not found at 100 mg/kg.  The result was an increase in testes size, rate of mating, libido, and fertility.
Nathan Goodyear

Low-Dose Hydrocortisone for Treatment of Chronic Fatigue Syndrome, September 23/30, 199... - 0 views

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    this study revealed symptom improvement with hydrocortisone treatment in those with CFS. Pre/post treatment was with serum cortisol and not salivary cortisol.  This is a weakness of the study.  The starting dosage of 25-30 mg hydrocortisone is high and with inadequate evaluation, this high dosage could have resulted in high dosage and adrenal suppression.  
Nathan Goodyear

Neuroendocrine disorders after... [J Neurol Neurosurg Psychiatry. 2008] - PubMed - NCBI - 0 views

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    The majority of people with PTHP after TBI remain undiagnosed.  The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency.  It does not have to be total pituitary failure.  Deficiencies can be isolated.
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | The Neur... - 0 views

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    TBI results in hormone disruption in 25-69% of those effected.  The major cause is a pituitary/neuro-endocrine effect.  This has been described since the early 20th century.
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

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    with an estimated 25% of Americans with non-alcoholic fatty liver disease (NAFLD), elevated liver enzymes are becoming a more common finding.  Nice review article on what the tests mean and what disease are underlying.
Nathan Goodyear

Comparative Studies of the Estrogen Receptors β and α and the Androgen Recept... - 0 views

  • ER-β is predominately immunolocalized in basal cells and to a lesser extent in stromal cells of the morphologically normal human prostate
  • ER-α is detected in stromal cells and rarely in basal cells of the normal gland
  • AR was predominately localized in the nuclei of differentiated secretory cells and variably in basal cells of the normal acinar/duct unit as well as in stromal cells
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  • Hall and colleagues44 have reported that ER-β functions as a transdominant inhibitor of ER-α transcription and that it acts to decrease overall cellular sensitivity to estradiol
  • The expression of ER-β was diminished in high-grade dysplasias when compared to normal glands and lower grade lesions.
  • The transition from normal to low/moderate dysplastic glands in the peripheral zone was marked by the appearance of ER-β homogeneously immunostained nuclei in secretory as well as basal cells with no changes in the localization of the other receptors.
  • proliferative signals mediated by AR in basal cells or by ER-α and AR in stromal cells may be opposed by the purported growth-inhibitory action of ER-β25, 26, 27, 28 localized in basal cells.
  • The diminution of ER-β expression in high-grade dysplasias and grade 4/5 cancers may be therefore related to the alteration of DNA methylation pattern in CpG islands of the promoter, resulting in down-regulation of the receptor at the transcriptional level
  • based on the proposed anti-proliferative function of the receptor,25, 26, 27, 28 the presence of ER-β in secretory cells of low/moderate-grade lesions may represent a transient abortive attempt to counter growth of these cells
  • the attrition of receptor-positive basal cells in the high-grade dysplasias may signify a continuing loss of growth inhibitory function mediated by ER-β in these precursor lesions
  • Our findings in prostate therefore differ from those reported for human colon cancer in which Folley and colleagues48 demonstrated that a selective loss of ER-β protein but not receptor message expression occurs in these neoplasms
  • Our findings therefore differed from those of Bonkhoff and colleagues33 who found immunostaining for the receptor in high-grade dysplasias and grade 4/5 carcinomas. Using in situ hybridization these authors also reported that a high percentage of dysplasias and carcinomas in their study contained cells that expressed ER-α message
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    Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.   In contrast, androgen receptors appeared to be equally expressed across all.
Nathan Goodyear

Creatine monohydrate supplement... [Int J Sport Nutr Exerc Metab. 2000] - PubMed - NCBI - 0 views

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    Creatine loading dose of 25 grams over 4 days shown to increase high-intensity exercise performance in both males/females.
Nathan Goodyear

Taylor & Francis Online :: The effect of longer-term creatine supplementation on elite ... - 0 views

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    4 days of creatine loading with 25 grams improved times in elite swimmers in 19/22 individuals.  Two months provided no significant benefit.
Nathan Goodyear

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian Na... - 0 views

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    Study that followed breast screening for 25 years with mammograms finds that no decrease in mortality from regular mammograms.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Trends in Androgen Prescribing in the United St... - 0 views

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    A review of the prescribing patterns of androgens in the US.  Up to 25% of men are prescribed Testosterone without a test evaluation--scarry!
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