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Nathan Goodyear

Low testosterone - a risk marker rather than a risk factor for type 2 diabetes: The Jou... - 0 views

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    As I have been saying for awhile now, low Testosterone is the effect not the cause: new study finds that low T is a biomarker of diabetes and not a cause.  
Nathan Goodyear

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels: T... - 0 views

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    new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!
Nathan Goodyear

Cognitive effects of estradiol after menopause - 0 views

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    No benefit to memory for post menopause women with estradiol therapy.  This study looked at early and late menopause estrogen therapy.  The study also found no harm.  Only abstract available here.  These studies would do more scientific benefit if they would follow hormone levels.  This study did not touch on dementia; other studies have shown benefit from estrogen therapy  in preventing dementia in women.
Nathan Goodyear

Dietary patterns and the risk of major adverse cardiovascular events in a global study ... - 0 views

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    Mediterranean diet reduces major cardiovascular event incidence in those individuals with coronary artery disease.
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Nathan Goodyear

Light Therapy More Effective Than Prozac in Patients With Major Depression | Natural Me... - 0 views

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    new study finds that light therapy therapy for major depression outperformed prozac therapy.  This study was short at only 8 weeks.
spicesboard

Delegate Registration-International Spice Conference 2016 - 0 views

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    The dynamic 4-day International Spice Conference will discuss about the challenges faced by the industry and its solutions for decoding the spices in the 21st century.
spicesboard

International Spice Conference 2016 - Decoding Spices - 0 views

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    The dynamic 4-day International Spice Conference will discuss about the challenges faced by the industry and its solutions for decoding the spices in the 21st century.
spicesboard

Goa India - International Spice Conference 2016 - 0 views

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    Swaying palms, white-sand beaches and sparkling water with the sweet smell of sand and bougainvillea, doesn't it just sound heavenly? Goa, is this glorious slice of India that has a lot of these balmy beaches hugging the western coast bounded by the Arabian Sea. This is not just India's but one of the world's favourite tourist destinations.
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Conduce la enfermedad renal FSGS a Muerte - 0 views

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    Enfermedad renal FSGS es tipo común de la enfermedad renal crónica que puede agravar la insuficiencia renal en el tiempo.Conduce FSGS a la muerte?Es mortal?
laymoun

Entrepreneurship : How to exploit the bug to learn from it - 0 views

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    If you are wrong in your life then you are not going to become an never, the error is the real friend of every successful , so that he knows to walk steadily,march towards success and glamor. All successful people in life, already caught in the number of errors that have made their careers seem more honest, and therefore more successful.
Nathan Goodyear

Garlic and Heart Disease - 0 views

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    another positive study on Aged Garlic Extract in the treatment of hypertension, total cholesterol, and atherosclerosis.
Nathan Goodyear

Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Pr... - 0 views

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    low vitamin D associated with more aggressive prostate cancer. 
Nathan Goodyear

Revised estimates for the number of human and bacteria cells in the body | bioRxiv - 0 views

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    Good science always challenges established dogma.  Only abstract available here.  Study calls into question the 10:1 claim: bacteria out number human cells by 10:1.  New study finds ratio more near 1:1.  
Nathan Goodyear

Endometriosis and Risk of Coronary Heart Disease - 0 views

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    Women with endometriosis found to be at increased risk for cardiovascular disease.  The likely causation is inflammation.
Nathan Goodyear

Study finds testosterone supplementation reduces heart attack risk in men with heart di... - 0 views

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    This is simply a public release prior to publication.  Study found that Testosterone therapy in men with existing CAD did not increased adverse events; in fact, it appeared to decrease the adverse events when compared to that of the non-treatment group.  Study not yet available to read the specific design, stats, and results which would be required to better analyze the actually results.
Nathan Goodyear

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multi... - 0 views

  • Patients received a median of six doses of nivolumab
  • four of the first 12 patients had partial responses
  • Nine (24% [95% CI 15–33]) of 37 patients achieved a response (seven partial responses and two complete responses
  • ...16 more annotations...
  • no treatment-related deaths
  • the most common adverse events were anaemia (26 [70%]), fatigue (25 [68%]), and rash
  • hypothyroidism
  • hypothyroidism
  • nivolumab-related autoimmune hypothyroidism, which resolved after a short course of corticosteroids
  • No grade 3 or 4 adverse events occurred
  • Nivolumab resulted in objective responses in 24% of patients with metastatic SCCA
  • Historically, doublet chemotherapy with cisplatin and fluorouracil has been the most common treatment for patients with metastatic SCCA
  • our results suggest that immune checkpoint blockade agents might extend overall survival beyond currently available therapies, especially if provided early in the disease treatment course
  • the dose of nivolumab we used differs from the 2016 recommendation of a fixed 240 mg every 2 weeks
  • 25% of patients develop distant metastases
  • most patients with localised SCCA are cured by chemoradiation
  • More than 90% of cases of SCCA are linked to prior infection with human papillomavirus (HPV)
  • Within tumour cells, HPV oncoproteins are immunogenic and can trigger an anti-tumour host immune response by recruitment of tumour-infiltrating lymphocytes
  • Tumour cells express PD-L1 and, on binding its inhibitory receptor PD-1 on the surface of T cells, downregulate T-cell activation and thwart the local anti-tumour immune response
  • Nivolumab is a humanised monoclonal antibody against PD-1 that disrupts this interaction, enabling T-cell cytotoxicity. It has activity as a monotherapy in advanced solid cancers, such as head and neck cancer, melanoma, non-small-cell lung cancer, and renal cell carcinoma
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    study finds nivolumab helpful in some patients with surgically unresectable or metastatic anal cancer.  The dose used was 3 mg/kg every 2 weeks. 
Nathan Goodyear

Ozone in Medicine: Clinical Evaluation and Evidence Classification of the Systemic Ozon... - 0 views

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    Ozone
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