Group items tagged

vitamin C found to decrease inflammatory signaling.  In this study, they found a decrease in GM-CSF induction of  ROS due to vitamin C.  This was an in vitro study, but another flag in the claim that vitamin C reduces inflammation and ROS.

study finds "high dose" IV vitamin C benefited 3 of 5 patients in short 4 week study.  The "high dose" was not high dose at all, so that fact that a low dose of IV vitamin C will benefit dermatomysotis in over 50% of the patients in this very small study points to the question, what if actually high dose vitamin C is used.

current vitamin B12 recommendations are too low.  Proper vitamin B12 biomarker testing reveals this fact. The problem is most people fall prey to the lack of knowledge behind simple serum levels.  Simple B12 serum levels are woefully inadequate. Insurance would rather one stay with inadequate testing to save money, rather than actually read the science to learn about new testing.

So help me out here:  If IV vitamin C has been shown to prolong time to cancer relapse, aid in reducing tumor size, improve survival with chemotherapy, improve quality of life, improve physical function, reduce chemo side effects, improve energy, reduce nausea, aid insomnia, reduce constipation, and improve depression in cancer patient--then why does the author say that IV vitamin C is contentious?  Add that IV vitamin C has not been implicated in any deaths in cancer therapy.  Contrast that with chemotherapy.  Why again is this contentious?  Whom is best served by this being contentious?

animal study finds high-dose, pharmacologic vitamin C found to kill multiple myeloma cells via pro-oxidant effect found in similar studies in dealing with different cancers.

Meta-analysis finds that for every oral daily intake of 100 mg vitamin C, the risk of total mortality was decreased by 27% and the breast cancer specific mortality was decreased by 22%.  A lot of potential variables that can play into this equation.  However, oral vitamin C is poorly bioavailable, yet according to this meta-analysis, does provide significant health benefits and even prevention.  If health and breast cancer prevention is a goal, then vitamin C needs to play a role in your daily intake.

Nice study from a few years ago found that a low dose vitamin D3 (1200 IU) significantly reduced the relative risk of the flu in school age children.  Also of note, a significant reduction in asthma attacks in those children with asthma were significantly reduced in the vitamin D3 treated group.  One interesting thing about this study was that they did not check prior or during the study if vitamin D deficiency was even present.  This study was conducted in Japan

Vitamin D3 is better than D2.  Vitamin D3 replacement raised 25(OH)D, whereas vitamin D2 caused a decline in levels.

This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.

IV vitamin C improves anemia.  The only possible contribution of IV vitamin C and anemia is a G6PD deficiency.

Only abstract available here.  The quote that "the toxicity of vitamin E is very low" tells the story.  Always have levels evaluated to ensure need.  In this review of human studies, doses up to 3,200 IU daily "led to no consistent adverse effects".  Also consider the effects of vitamin K effects in those on vitamin E therapy.

IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.

Study finds oral vitamin C and vitamin E hamper mitochondrial repair needed in exercise.  

Nice review of the adjuvant effects of vitamin C and vitamin K3 in the process of autoschizis of cancer cells.

review article of studies on vitamin C and blood pressure finds mixed results.  I think it all comes down to dosing.  The authors highlight 2 studies to make their point. One find a significant reduction and another found a slight increase.  The dosing of the vitamin C was only 500 mg/day.  A woefully inadequate therapeutic dosing of vitamin C, especially when dealing with the significant deficiencies that can be found in disease states.

small study looked at patients with liver cirrhosis.  The authors used a low dose of IV vitamin C (5 grams) and found that this improved endothelial dysfunction.  Patients with cirrhosis were found to be low in vitamin C.  The IV vitamin C was well tolerated, despite a low dose.

This study shows that inflammation, CRP in this study, was inversely associated with low antioxidants ie. vitamin C.  This makes since as ROS are known to stimulate inflammation.  Vitamin C should be considered as a therapeutic option in those with inflammation.

editorial discussion of the benefit of vitamin D in mitochondrial function.   Those in the vitamin D repletion arm of the study had a quicker recovery time to restored phospho-creatinine levels.  The quicker the recovery of phospho-creatinine levels, the shorter recovery phase and the likely improvement in athletic performance.

IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.

Vitamin D3 is more potent (87%) and just a better form than is vitamin D2.