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Nathan Goodyear

Inflammation in Response to Glucose Ingestion Is Independent of Excess Abdominal Adipos... - 0 views

jcem.endojournals.org/...4071.abstract

PCOS polycystic ovarian syndrome inflammation TNF-alpha CRP women androgens testosterone

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat.  Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
Nathan Goodyear

CIRCULATING INFLAMMATORY MARKERS IN POLYCYSTIC OVARY SYNDROME: A SYSTEMATIC REVIEW AND ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3079565

PCOS polycystic ovarian syndrome inflammation CRP IL-6 TNF-alpha

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    It is well known that obesity increases CRP.  However, in this meta-analysis, CRP elevation in women with PCOS was found to be independent from obesity and as they concluded: "...chronic low-grade inflammation that may underpin the pathogenesis of this disorder".
Nathan Goodyear

High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome - 0 views

www.eje.org/...363.full.pdf+html

autoimmune thyroiditis autoimmune thyroid disease thyroid PCOS polycystic ovarian syndrome hormone hormoens autoimmune

shared by Nathan Goodyear on 03 Jun 13 - No Cached
  • Nathan Goodyear on 03 Jun 13
     
    Increased rate of autoimmune thyroid disease found in women with the hormonal imbalances found in PCOS.  
Nathan Goodyear

Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placeb... - 0 views

press.endocrine.org/...jc.2016-1858

resveratrol PCOS polycystic ovarian syndrome Testosterone DHEA hormones women insulin sensitivity insulin

shared by Nathan Goodyear on 30 Nov 16 - No Cached
  • Nathan Goodyear on 30 Nov 16
     
    Only abstract available.  Resveratrol found to reduce total Testosterone by 23% and DHEAS by 22% in women with PCOS;  a decrease in insulin by 32% and improved insulin sensitivity was also noted.
Nathan Goodyear

Biomedical Papers: The prevalence of non organ specific and thyroid autoimmunity in pat... - 0 views

biomed.papers.upol.cz/..._polycystic_ovary_syndrome.php

PTO autoimmune disease autoimmune thyroid PCOS polycystic ovarian syndrome hormones

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    high prevalence of thyroid antibodies, TPO, in women with PCOS.  This does not prove cause and effect, merely an association.  Both are inflammation driven.
Nathan Goodyear

High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome. - Pu... - 0 views

www.ncbi.nlm.nih.gov/...23548659

PCOS polycystic ovarian syndrome hormones TPO Hashimoto's thyroiditis thyroid

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    Autoimmune thyroid present in 1/3 of women with PCOS.
Nathan Goodyear

Polycystic Ovary Syndrome May Be an Autoimmune Disorder - 0 views

www.ncbi.nlm.nih.gov/...PMC4871972

PCOS polycystic ovarian syndrome TPO hormones inflammation autoimmune disease autoimmune

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    Article proposes that PCOS may be autoimmune.  Clearly it is inflammatory.
Nathan Goodyear

Metabolic and Endocrine Effects of a Polyunsaturated Fatty Acid-Rich Diet in Polycystic... - 0 views

academic.oup.com/...jc.2003-030666

PCOS polycystic ovarian syndrome PUFA fats polyunsaturated fats diet nutrition hormones

shared by Nathan Goodyear on 08 Feb 17 - No Cached
  • Nathan Goodyear on 08 Feb 17
     
    polyunsaturated fats found to improve PCOS
Nathan Goodyear

The polycystic ovary syndrome per se is not associated with increased chronic inflammation - 0 views

www.eje-online.org/...525.short

PCOS BMI fat overweight obese inflammation women CVD polycystic ovarian syndrome

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Nathan Goodyear on 10 May 12
     
    This study finds no association between PCOS and inflammation, when matched with age/BMI controls.  However, inflammation was associated with increased BMI.  Not all women with PCOS are overweight.  But, the majority are and this would contribute to inflammation and thus CVD.
Nathan Goodyear

Analysis of the vascular responses in a murine model of polycystic ovary syndrome - 0 views

joe.endocrinology-journals.org/...205.abstract

PCOS polycystic ovarian syndrome CVD DHT

shared by Nathan Goodyear on 24 Jul 13 - No Cached
  • Nathan Goodyear on 24 Jul 13
     
    Animal model of PCOS provides insight to changes in vascular response.  In this animal mode, DHT resulted in a decrease in vasorelaxation of arterial endothelium.
Nathan Goodyear

Hyperhomocysteinaemia is as... [Eur J Obstet Gynecol Reprod Biol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24169034

homocysteine women hormone Testosterone hormones PCOS polycystic ovarian syndrome polycystic ovary syndrome

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    Women with PCOS will have hyperandrogenism. This study finds an association between this increased androgen levels and hyperhomocysteinemia.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCO... - 0 views

jcem.endojournals.org/...jc.2013-2674.abstract

statin insulin sensitivity resistance PCOS diabetes polycystic ovarian syndrome

shared by Nathan Goodyear on 28 Oct 13 - No Cached
  • Nathan Goodyear on 28 Oct 13
     
    statin therapy worsens insulin sensitivity in women with PCOS.  Statin therapy in this study did lower CRP, LDL and triglycerides.  Of note, DHEA decreased. This should be no surprise as statins are HMG-CoA reductase inhibitors which reduces hormone synthesis from cholesterol.
Nathan Goodyear

Androgen activation by 5α-reductase in patients with PCOS - 0 views

www.endocrine-abstracts.org/...ea0021sig3.1.htm

PCOS 5 alpha reductase polycystic ovarian syndrome polycystic ovary syndrome insulin obesity female hormone hormones

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    5alpha-reductase PCOS.  Insulin and obesity are associated with increased 5alpha-reductase activity.
Nathan Goodyear

http://www.ccjm.org/content/70/1/31.full.pdf - 0 views

www.ccjm.org/...31.full.pdf

PCOS polycystic ovarian syndrome polycystic ovary syndrome female hormone hormones

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    brief review of PCOS; not so much the treatment, but the discussion of the common biochemical findings.
Nathan Goodyear

Licorice reduces serum testosterone in heal... [Steroids. 2004 Oct-Nov] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15579328

PCOS polycystic ovarian syndrome polycystic ovary syndrome licorice licorice root extract Glycyrrhiza Testosterone women female hormones hormone herbal herbs natural therapy

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Licorice root extract, also known as glycyrrhizic acid, found to quickly reduce endogenous Testosterone production in women.  The proposed mechanism is via inhibition of 17-hydroxysteroid dehydrogenase and 17-20 Lyase.  This is a good adjuvant in the treatment of PCOS.
Nathan Goodyear

Focus on metabolic and nutritional corre... [Arch Gynecol Obstet. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25200687

PCOS polycystic ovarian syndrome polycystic ovary syndrome nutrition diet lifestyle women female hormone hormones

shared by Nathan Goodyear on 12 Sep 14 - No Cached
  • Nathan Goodyear on 12 Sep 14
     
    Dietary lifestyle changes still prove to be the most effective treatment strategy for women with PCOS.
Nathan Goodyear

Androgens and polycystic ovary syndrome. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19390322

PCOS polycystic ovarian syndrome Testosterone androgens women female hormone hormones

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • Nathan Goodyear on 10 Mar 15
     
    Only abstract available here. Exact complexity of the signaling involved in PCOS is yet to be determined, but increased androgens in women is proving to be a strong link between PCOS and metabolic dysfunction.
Nathan Goodyear

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adole... - 0 views

eje-online.org/...1093.long

PCOS polycystic ovarian syndrome CRP inflammation insulin insulin resistance women female hormone hormones androgens Testosterone hyperandrogenism

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • subjects with hyperandrogenemic phenotypes displayed the greatest degree of hyperinsulinemia, β-cell function, and chronic inflammation
  • The rise in serum androgens is accompanied by excess insulin secretion, suggesting that insulin directly stimulates ovarian androgen production
  • The degree of hyperinsulinemia does not seem to be directly correlated with the development of HS
  • ...7 more annotations...
  • higher androgen and insulin levels stimulate hair growth
  • genetic and epigenetic changes may be involved in the pathogenesis of PCOS
  • HA has been identified as an important risk factor for MS and dyslipidemias in premenopausal women and adolescents
  • In our study, HA was found to be an independent risk factor for MS as previously reported by Coviello et al.
  • obesity and HA, and not insulin resistance, are the major determinants of chronic inflammation and risk of atherosclerosis in adolescents with PCOS
  • use of an inflammation marker may help identify high-risk females with PCOS
  • hyperandrogenemic PCOS phenotypes have greatest degree of hyperinsulinemia, insulin resistance, and inflammation
  • Nathan Goodyear on 10 Mar 15
     
    Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).
Nathan Goodyear

Serum Leptin Level in Women with Polycystic Ovary Syndrome: Correlation with Adiposity,... - 0 views

www.ncbi.nlm.nih.gov/...PMC3728861

women female hormone hormones PCOS polycystic ovarian syndrome leptin Testosterone

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Increasing leptin levels in women with/without PCOS correlate positively with serum Testosterone levels.
Nathan Goodyear

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary ... - 0 views

www.nature.com/...srep22883

epigenetics PCOS polycystic ovarian syndrome

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Study finds statistically increased methylation of many genes in women with PCOS: it is called epigenetics.
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