Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking m... - 0 views
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Accumulating evidence suggests that niclosamide targets multiple signaling pathways such as nuclear factor-kappaB (NF-kB), Wnt/β-catenin, and Notch, most of which are closely involved with cancer stem cell proliferation
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The transcription factor NF-κB has been demonstrated to promote cancer growth, angiogenesis, escape from apoptosis, and tumorigenesis
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NF-κB is sequestered in the cytosol of resting cells through binding the inhibitory subunit IκBα
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