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Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237 Th1 pathways typically produce activation of cytotoxic T lymphocytes (Tc), NK cells, macrophages, and monocytes, all of which can attack cancer cells and generally defend against tumors. 55 IFN-gamma and other Th1 cytokines are typically lower in advanced cancer patients, while the Th2 marker IL-4 can be higher or unchanged.56 Nodules of non-small cell lung cancer freshly removed from patients expressed a marked imbalance toward Th2, as did biopsy samples from basal cell carcinoma.57 In prostate cancer patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed Th1-suppressive cytokine, and heightened IL-10 is a common factor in cancer.55 IL-10 has a variety of suppressive effects that include inhibiting Th1 cytokine production, down-regulating APC and NK cell function, and lowering overall T-cell proliferation.57 Especially under the influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10 that suppresses nearby killer cells. Tumor-derived IL-10 has been documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma, and renal cell and colon carcinoma.57 IL-12 is another cytokine that can be up-regulated by Th1 activity and inhibited by Th2.59 A low IL-12/IL-10 ratio was found in cervical cancer patients.55 Recent clinical studies suggest elevated IL-10 is predictive of a poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors of Th1 and promoters of Th2 activity, the recognized capability of cancerous tissue to suppress immunity is readily rationalized.

Vitamin D may suppress infections which lead to development of Multiple Sclerosis Steven R Brenner, None (16 August 2007) J Neurol Neurosurg Psychiatry 2008 I read the article with reference to the inverse relationship between multiple sclerosis clinical activity and deficiency of vitamin D by Soilu-Hannienen (1) with interest, and was considering what mechanism could be in play to cause such a relationship. 25-hydroxylated metabolites of vitamin D act as intracellular regulators of the synthesis and action of defensin (2) molecules against bacterial antigens, defensin being an endogenously synthesized antimicrobial substance (2). Human cathelicidin antimicrobial peptide gene is a target of vitamin D receptor and is strongly up-regulated by 1,25-dihydroxyvitamin D3, indicating vitamin D receptor and the 1,25-dihydroxyvitaminD3 regulate primate innate immunity (3)

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. Golovko O, Nazarova N, Tuohimaa P. Life Sci. 2005 Jun 17;77(5):562-77. Epub 2005 Feb 25. PMID: 15904673 doi:10.1016/j.lfs.2004.10.072 Combined addition of human recombinant TNF-alpha with calcitriol or CB1093 cause enhanced effect in induction of apoptosis. We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required. Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer.

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Hu Y, Davies GE. Fitoterapia. 2009 Oct 25. [Epub ahead of print] PMID: 19861153 doi:10.1016/j.fitote.2009.10.010 Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPARgamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity.

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Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.\nGombart AF, Borregaard N, Koeffler HP.\nFASEB J. 2005 Jul;19(9):1067-77.\nPMID: 15985530

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Use of vitamin D in clinical practice. Cannell JJ, Hollis BW. Altern Med Rev. 2008 Mar;13(1):6-20. PMID: 18377099 The recent discovery--from a meta-analysis of 18 randomized controlled trials--that supplemental cholecalciferol (vitamin D) significantly reduces all-cause mortality emphasizes the medical, ethical, and legal implications of promptly diagnosing and adequately treating vitamin D deficiency. Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. Vitamin D's final metabolic product is a potent, pleiotropic, repair and maintenance, seco-steroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. One of the most important genes vitamin D up-regulates is for cathelicidin, a naturally occurring broad-spectrum antibiotic. Natural vitamin D levels, those found in humans living in a sun-rich environment, are between 40-70 ng per ml, levels obtained by few modern humans. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis and to assure treatment is adequate and safe. Three treatment modalities exist for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D3 supplementation. Treatment of vitamin D deficiency in otherwise healthy patients with 2,000-7,000 IU vitamin D per day should be sufficient to maintain year-round 25(OH)D levels between 40-70 ng per mL. In those with serious illnesses associated with vitamin D deficiency, such as cancer, heart disease, multiple sclerosis, diabetes, autism, and a host of other illnesses, doses should be sufficient to maintain year-round 25(OH)D levels between 55 -70 ng per mL. Vitamin D-deficient patients with serious illness should not only be supplemented more aggressively than the well, they should have more frequent monitoring of serum 25(OH)D and serum calcium. Vitamin D should always be

Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis-connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis. Part II, The Vitamin K Connection to Cardiovascular Health, reviews the ways in which vitamin K regulates calcium utlization, preventing vascular and soft tissue calcification while complimenting the bone-building actions of vitamin D, and also discusses vitamin K safety and dosage issues, and the necessity of providing vitamin K and vitamin A along with vitamin D to preclude adverse effects associated with hypervitaminosis D.

Scientists have known that cruciferous vegetables contain a host of chemopreventive agents that act in many different ways to block cancer development.2 Key among these products are indole-3-carbinol (I3C) and sulforaphane.1,3 Cancer cells need a brisk blood supply to support their rampant growth and reproduction. Preliminary studies in vitro and in vivo have found that apigenin inhibits blood vessel growth (angiogenesis) in human ovarian cancer cells, blocking production of two main signaling molecules required to stimulate vessel growth.20,21 Scientists confirmed this effect in ovarian cancer cells, also finding that apigenin strongly inhibits cell proliferation.22 Apigenin and BITC: Complementary Cancer Protection Cancer cells also need energy to support their frenetic reproductive activity. Researchers applied apigenin to human pancreatic cancer cells in culture and studied the cells' uptake of glucose.14 Astonishingly, they found that apigenin deprived energy-hungry cancer cells of glucose to support their voracious appetites and aggressive growth. It did this by down-regulating vital glucose-transporting proteins in cancer cells. This approach could effectively starve deadly cancer cells and stop them in their tracks. Another cruciferous vegetable component receiving rave reviews is the sulfur-containing molecule benzyl isothiocyanate, or BITC (pronounced "bitsy"). As with apigenin, population studies have shown that higher intakes of BITC correlate with reduced risk of cancers of the lung, breast, and colon30 while blocking cancer development in a host of different ways. BITC induces breast cancer cell death by apoptosis (programmed cell death), interfering with cancer cells' energy utilization and causing them to die off before they can contribute to tumor growth.31,32 In human ovarian cancer cells, BITC induces apoptosis by a different mechanism. It stimulates "signaling" molecules that tell cancer cells it's time to close up shop.

"Numerous studies link Vitamin D and influenza, as well as Vitamin D and respiratory infections more generally. This vitamin up-regulates genetic expression of various endogenous antimicrobial peptides (AMP), which exhibit broad-spectrum microbicidal activity against bacteria, fungi, and viruses. Reports discussed below indicate that susceptibility to influenza is reduced with higher levels of sun exposure or vitamin D supplementation. Seasonal variation of vitamin D levels in humans can help explain the seasonality of flu epidemics."

"Berberine is a quaternary ammonium salt from the group of isoquinoline alkaloids. It is found in such plants as Berberis, goldenseal (Hydrastis canadensis), and Coptis chinensis, usually in the roots, rhizomes, stems, and bark. Berberine is strongly yellow colored, which is why in earlier times berberis species were used to dye wool, leather and wood. Wool is still today dyed with berberine in Northern India Berberine (BBR) is a natural compound with up-regulating activity on both low-density-lipoprotein receptor (LDLR) and insulin receptor (InsR). This one-drug-multiple-target characteristic might be suitable for the treatment of metabolic syndrome.[12] Berberine has been tested and used successfully in experimental[13] and human diabetes mellitus.[14][15][16] Berberine has been shown to lower elevated blood glucose as effectively as metformin.[17] The mechanisms include inhibition of aldose reductase,[18] inducing glycolysis,[19] preventing insulin resistance[20] through increasing insulin receptor expression[14] and acting like incretins. Berberine has drawn extensive attention towards its antineoplastic effects.[43][44] It seems to suppress the growth of a wide variety of tumor cells including breast cancer,[45] leukemia, melanoma,[46] epidermoid carcinoma, hepatoma, oral carcinoma, tongue carcinoma,[47] glioblastoma, prostate carcinoma, gastric carcinoma.[48][49] Animal studies have shown that berberine can suppress chemical-induced carcinogenesis, tumor promotion, tumor invasion,[50][51][52][53][54] prostate cancer,[55][56][57][58] neuroblastoma,[59][60] and leukemia.[34][61] It is a radiosensitzer of tumor cells but not of normal cells

Dietary cholesterol and the risk of cardiovascular disease in patients: a review of the Harvard Egg Study and other data. Jones PJ. Int J Clin Pract Suppl. 2009 Oct;(163):1-8, 28-36. English, French. PMID: 19751443 For many years, both the medical community and the general public have incorrectly associated eggs with high serum cholesterol and being deleterious to health, even though cholesterol is an essential component of cells and organisms. It is now acknowledged that the original studies purporting to show a linear relation between cholesterol intake and coronary heart disease (CHD) may have contained fundamental study design flaws, including conflated cholesterol and saturated fat consumption rates and inaccurately assessed actual dietary intake of fats by study subjects. Newer and more accurate trials, such as that conducted by Frank B. Hu of the Harvard School of Public Health (1999), have shown that consumption of up to seven eggs per week is harmonious with a healthful diet, except in male patients with diabetes for whom an association in higher egg intake and CHD was shown. The degree to which serum cholesterol is increased by dietary cholesterol depends upon whether the individual's cholesterol synthesis is stimulated or down-regulated by such increased intake, and the extent to which each of these phenomena occurs varies from person to person. Several recent studies have shed additional light on the specific interplay between dietary cholesterol and cardiovascular health risk. It is evident that the dynamics of cholesterol homeostasis, and of development of CHD, are extremely complex and multifactorial. In summary, the earlier purported adverse relationship between dietary cholesterol and heart disease risk was likely largely over-exaggerated.

The Nutrition of Mango Juice Mango juice contains a number of valuable nutrients. The naturally fulfilling fruit beverage also acts as a beneficial dietary food item that aids in normal bodily functions and the prevention of health risks and disease. Nutritional Content Like many other natural fruit drinks, mango juice, sometimes referred to as mango nectar, packs a variety of both vitamins and minerals. Each cup of mango juice adds a more than feasible source of both vitamins A and C to any diet. Without added sugars, pure mango nectar contains about 30 grams of sugary carbohydrates per cup. Although mangos contain moderate to high levels of carbohydrates, they cause little fluctuation in blood-sugar levels. This process lets the body maintain appetite and metabolic processes much easier. Plus, none of the calories found in mangos comes from fat, making the juice an easily digestible, energy providing drink. Health Benefits One cup of mango juice contains over 60% of the daily recommended intake of vitamin C, which helps the body regulate enzymes and metabolic processes. Mangos also have high levels of vitamin A, with one cup providing nearly 40% of the daily required valued. This important nutrient helps maintain healthy eye function and growth, gene transcribing and the maintenance of healthy skin tissue. Mango juice also provides a good source of calcium and iron. Iron helps the body eliminate free radicals, while calcium assists with the formation of healthy teeth and bones. Health Warnings Consuming too much mango juice will lead to an excess amount of sugars within the body. Too much sugar will increase fat storage and lead to weight gain. However, some athletes benefit from loading up on complex and simple sugars before long-lasting events.

Mango juice contains a number of valuable nutrients. The naturally fulfilling fruit beverage also acts as a beneficial dietary food item that aids in normal bodily functions and the prevention of health risks and disease.

Nutritional Content
Like many other natural fruit drinks, mango juice, sometimes referred to as mango nectar, packs a variety of both vitamins and minerals. Each cup of mango juice adds a more than feasible source of both vitamins A and C to any diet. Without added sugars, pure mango nectar contains about 30 grams of sugary carbohydrates per cup.

Although mangos contain moderate to high levels of carbohydrates, they cause little fluctuation in blood-sugar levels. This process lets the body maintain appetite and metabolic processes much easier. Plus, none of the calories found in mangos comes from fat, making the juice an easily digestible, energy providing drink.

Nutritional Content of Mango Juice per 100 ml
Energy: 58 Kcal
Fat: NIL
Carbohydrate: 14.6 g
Vitamin C: 10.34 mg
Sugar: 14.5 g
Iron: 0.3 mg
Protein: 0.11 g
Sodium: 15mg

Health Benefits

One cup of mango juice contains over 60% of the daily recommended intake of vitamin C, which helps the body regulate enzymes and metabolic processes. Mangos also have high levels of vitamin A, with one cup providing nearly 40% of the daily required valued. This important nutrient helps maintain healthy eye function and growth, gene transcribing and the maintenance of healthy skin tissue.

Mango juice also provides a good source of calcium and iron. Iron helps the body eliminate free radicals, while calcium assists with the formation of healthy teeth and bones.

Health Warnings

Consuming too much mango juice will lead to an excess amount of sugars within the body. Too much sugar will increase fat storage and lead to weight gain.

Brand History The company was founded in the year 1977 by first generation entrepreneur Mr. Kanti Parasrampuria. He has a vast work experience in the field of textiles, beverages and plastics and a profound business acumen and managerial alacrity. The company benefits from his expertise and guidance and also relies on a highly experienced and well qualified professional management team for its day to day operations. Brand Advantage The company owns a fully automatic plant to manufacture 6000 liters per hour of fruit based beverages at Mandideep near Bhopal (M.P.), India. It is a state-of-art plant with two PET blowing and filling lines, one V-Pak (aseptic juice carton) and one stand-up pouch filling line. The infrastructure is par-excellence and ensures that delicious, safe and hygienic products are delivered to the market. The beverages made by us are untouched by hand are produced under stringent conditions. The beverage division has achieved the prestigious ISO 22000:2005 including HACCP certification from the Swiss multinational certification agency SGS. The facility is also certified ISO 9001:2008 from ICS. All the equipment's used in the plant are installed by vendors that are approved by big multinational beverage companies. The raw and packaging material procured is from good quality sources which are first audited for quality. The plant is centrally located in Bhopal with very good road, air and rail link to rest of the country. Our products are currently available in 15 states of India (updated Feb 2013) and counting. Mango dash created a great deal of excitement in its category and celebrated the indulgence in mangoes like no other brand had done before. While other players have portrayed the mango as a simple and innocent fruit, Mango dash celebrates the sheer indulgence and sensuality involved in consuming a mango. The creative 'Aamsutra' idea communicates the experience of extreme sensuous pleasure through the act of drinking M

Mango juice is a known health drink and Mango Drinks is also popular all over the world. Mangoes are an excellent source of Vitamins A and C. Mangoes are very rich in fiber content. Mango Juice contain vitamin E which works to regulate and boost you Health hormones. Vitamin E is said to be one of the most beneficial vitamins in order to boost your Health Performance life. SO in order to boost your Health Performance, eat plenty of mangoes regularly. High in vitamins: If you're looking to stave off illness, mango juice has you covered. A cup of mango contains anywhere from 60 to 100 per cent of your daily recommended vitamin C, and about 40-50 per cent of your daily recommended vitamin A. Together, these vitamin complexes also benefit teeth and gums, eye function, neurologic function and better nutrient absorption. Stable blood sugar: Because mangoes and mango juice are so high in natural sugars and fibre, it can work to sustain healthy blood sugar levels. Consider the way you feel in the late afternoon - tired and worn out. This can be a sign of low blood sugar as a result of poor dietary choices or not eating often enough. Drive and performance: One of the known benefits of mango juice is the mango's known ability to help increase Health drive and performance. It's still unknown just how mangoes can boost a lagging Health drive, but it's thought that the fruit's high amount of vitamin E might be what does the trick. Improved libido: What's more, eating a diet high in whole, healthy foods can also help improve libido and Performance, so mango Juice can further add to a better healthy life through a healthier diet overall. How to enjoy this libido food: Peel the mango juice, cut the peach and slice up some strawberries, and feed your woman while she's giving you oral Health Performance . Mango juice contains Vitamin E which helps the hormonal system to function in a better manner. This improves of the your life also Health Performa

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