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Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

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    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237 Th1 pathways typically produce activation of cytotoxic T lymphocytes (Tc), NK cells, macrophages, and monocytes, all of which can attack cancer cells and generally defend against tumors. 55 IFN-gamma and other Th1 cytokines are typically lower in advanced cancer patients, while the Th2 marker IL-4 can be higher or unchanged.56 Nodules of non-small cell lung cancer freshly removed from patients expressed a marked imbalance toward Th2, as did biopsy samples from basal cell carcinoma.57 In prostate cancer patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed Th1-suppressive cytokine, and heightened IL-10 is a common factor in cancer.55 IL-10 has a variety of suppressive effects that include inhibiting Th1 cytokine production, down-regulating APC and NK cell function, and lowering overall T-cell proliferation.57 Especially under the influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10 that suppresses nearby killer cells. Tumor-derived IL-10 has been documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma, and renal cell and colon carcinoma.57 IL-12 is another cytokine that can be up-regulated by Th1 activity and inhibited by Th2.59 A low IL-12/IL-10 ratio was found in cervical cancer patients.55 Recent clinical studies suggest elevated IL-10 is predictive of a poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors of Th1 and promoters of Th2 activity, the recognized capability of cancerous tissue to suppress immunity is readily rationalized.
Matti Narkia

Effects of probiotic bacteria and their genomic DNA on TH1/TH2-cytokine production by p... - 0 views

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    Effects of probiotic bacteria and their genomic DNA on TH1/TH2-cytokine production by peripheral blood mononuclear cells (PBMCs) of healthy and allergic subjects. Ghadimi D, Fölster-Holst R, de Vrese M, Winkler P, Heller KJ, Schrezenmeir J. Immunobiology. 2008;213(8):677-92. Epub 2008 Apr 2. PMID: 18950596 doi:10.1016/j.imbio.2008.02.001
Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

  •  
    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237
Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

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    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and diseaseAlternative Medicine Review, August, 2003 by Parris Kidd
Matti Narkia

Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon ... - 0 views

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    Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. Chapkin RS, Davidson LA, Ly L, Weeks BR, Lupton JR, McMurray DN. J Nutr. 2007 Jan;137(1 Suppl):200S-204S. PMID: 17182826
Matti Narkia

PLoS ONE: Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in ... - 0 views

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    Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis.\nSmolders J, Thewissen M, Peelen E, Menheere P, Cohen Tervaert JW, Damoiseaux J, Hupperts R.\nPLoS One. 2009 Aug 13;4(8):e6635.\nPMID: 19675671
Matti Narkia

Investigation of the immunomodulatory effects of Lactobacillus casei and Bifidobacteriu... - 0 views

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    Investigation of the immunomodulatory effects of Lactobacillus casei and Bifidobacterium lactis on Helicobacter pylori infection. Zhang L, Su P, Henriksson A, O'Rourke J, Mitchell H. Helicobacter. 2008 Jun;13(3):183-90. PMID: 18466393 DOI: 10.1111/j.1523-5378.2008.00595.x
Matti Narkia

The immunobiology of mushrooms. - Exp Biol Med (Maywood). 2008 Mar - 0 views

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    The immunobiology of mushrooms. Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME. Exp Biol Med (Maywood). 2008 Mar;233(3):259-76. Review. PMID: 18296732 doi: 10.3181/0708-MR-227
Matti Narkia

Vitamin D and autoimmunity: new aetiological and therapeutic considerations -- Arnson e... - 0 views

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    itamin D and autoimmunity: new aetiological and therapeutic considerations. Arnson Y, Amital H, Shoenfeld Y. Ann Rheum Dis. 2007 Sep;66(9):1137-42. Epub 2007 Jun 8. Review. PMID: 17557889 doi:10.1136/ard.2007.069831
Matti Narkia

Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity? - Are Omega-3... - 0 views

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    K. L. Fritsche Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity? J. Nutr., December 1, 2005; 135(12): 2916S - 2917S.
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