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Matti Narkia

Prognostic Effects of 25-Hydroxyvitamin D Levels in Early Breast Cancer -- Goodwin et a... - 0 views

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    Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer.
    Goodwin PJ, Ennis M, Pritchard KI, Koo J, Hood N.
    J Clin Oncol. 2009 Aug 10;27(23):3757-63. Epub 2009 May 18.
    PMID: 19451439
    DOI: 10.1200/JCO.2008.20.0725

    Conclusion Vitamin D deficiency may be associated with poor outcomes in breast cancer.
Matti Narkia

Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of su... - 0 views

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    SSeason of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.
    Porojnicu AC, Robsahm TE, Ree AH, Moan J.
    Br J Cancer. 2005 Sep 5;93(5):571-4.
    PMID: 16136030
    doi:10.1038/sj.bjc.6602722

    Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with approximately 20% lower case fatality for patients diagnosed during autumn vs winter diagnosis (RR = 0.783, 95% CI,-0.62 to 0.99; P = 0.041). Notably, the improved autumnal survival rate was higher than 60% (RR = 0.364, 95% CI, -0.15 to 0.87; P = 0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy.

    In conclusion, we have found that the prognosis of Hodgkin's lymphoma is significantly correlated with the season of diagnosis, particularly for patients younger than 30 years. This seasonal effect is presumably due to the vitamin D3 synthesis in skin during sun exposure. The present findings should encourage further investigations of the possible adjuvant role of vitamin D derivatives in cancer therapy
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