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Matti Narkia

Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and g... - 0 views

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    Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers.
    Chen W, Dawsey SM, Qiao YL, Mark SD, Dong ZW, Taylor PR, Zhao P, Abnet CC.
    Br J Cancer. 2007 Jul 2;97(1):123-8. Epub 2007 Jun 5.
    PMID: 17551495

    We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal and gastric cancers among subjects who developed cancer over 5.25 years of follow-up, including 545 oesophageal squamous cell carcinomas (ESCC), 353 gastric cardia adenocarcinomas, 81 gastric noncardia adenocarcinomas, and an age- and sex-stratified random sample of 1105 subjects.

    We found no associations for gastric cardia or noncardia adenocarcinoma. Among subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women. Further refinements of the analysis did not suggest any factors, which could explain this unexpected result.

    In conclusion, we found a direct association between higher serum 25(OH)D concentration and increased risk of ESCC in men but not women in a large population-based prospective cohort study from rural China. We found no association with risk of gastric cardia or noncardia adenocarcinoma in either sex. Greater than 50% of our cohort had an inadequate serum 25(OH)D concentration, yet higher concentrations were associated with increased risk of ESCC compared to lower concentrations.
Matti Narkia

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xeno... - 0 views

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    Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
    Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
    Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
    PMID: 19303753

    Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Matti Narkia

Berberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho K... - 0 views

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    Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.
    Tang F, Wang D, Duan C, Huang D, Wu Y, Chen Y, Wang W, Xie C, Meng J, Wang L, Wu B, Liu S, Tian D, Zhu F, He Z, Deng F, Cao Y.
    J Biol Chem. 2009 Oct 2;284(40):27456-66. Epub 2009 Aug 3.
    PMID: 19651779
Matti Narkia

Dietary vitamin D and cancers of the oral cavity and esophagus -- Lipworth et al. 20 (9... - 0 views

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    Dietary vitamin D and cancers of the oral cavity and esophagus.
    Lipworth L, Rossi M, McLaughlin JK, Negri E, Talamini R, Levi F, Franceschi S, La Vecchia C.
    Ann Oncol. 2009 Sep;20(9):1576-81. Epub 2009 Jun 1.
    PMID: 19487490

    Conclusion: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
Matti Narkia

DCA and vanadium combination - The DCA Site - Updating You on DCA and Cancer - Dichloro... - 0 views

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    Simultaneously Blocking Glycolysis and Fat Metabolism

    Can the use of DCA and a fatty acid metabolism blocker together force more cancer cells into using aerobic metabolism?

    Tim McGough used green tea extract, which contains EGCG, in his fantastic response.

    DCA works by reactivating mitochondria and shifts metabolism from glycolysis to glucose oxidation. Hopefully the cancer cell will then undergo apoptosis. However, cancer cells have an alternate energy source: fat metabolism. This page explores to possibility of blocking fat metabolism to help force the cell into apoptosis.

    Oral squamous cell carcinoma is a cancer that does not respond well to DCA. This study, Head and Neck Cancer Cell Lines Are Resistant to Mitochondrial-Depolarization-Induced Apoptosis states:

    "Results: ΔΨm in head and neck cell lines started to show slight loss of ΔΨm, while HL-60 showed significant loss of ΔΨm after 30 min of treatment. All cell lines demonstrated complete mitochondrial depolarization within 24 h, however, only the control cell line HL-60 underwent apoptosis. In addition, HNSCC cell lines did not demonstrate cytoplasmic cytochrome c release despite significant mitochondrial membrane depolarization, while HL-60 cell initiated apoptosis and cytochcrome c release after 24 h of treatment. Conclusions: Head and neck cancer cell lines exhibit defects in mitochondrial-membrane-depolarization-induced apoptosis as well as impaired release of cytochrome c despite significant mitochondrial membrane depolarization. Proximal defects in the mitochondrial apoptosis pathway are a feature of HNSCC.(head and neck squamous cell carcinoma)"

    Note that although the cell lines were depolarized, apoptosis did not occur. So I checked to see if fatty acid metabolism is used by squamous cell carcinoma.
Matti Narkia

Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral car... - 0 views

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    Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation.
    Gonzalez de Mejia E, Song YS, Ramirez-Mares MV, Kobayashi H.
    J Agric Food Chem. 2005 Mar 23;53(6):1966-73.
    PMID: 15769122
Matti Narkia

Perioperative immunonutrition in head and neck cancer. - Wiley InterScience :: JOURNALS... - 0 views

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    Perioperative immunonutrition in head and neck cancer.
    Sorensen LD, McCarthy M, Baumgartner MB, Demars CS.
    Laryngoscope. 2009 May 20. [Epub ahead of print]
    PMID: 19459146
    DOI: 10.1002/lary.20494
Matti Narkia

Selenium linked to lower skin cancer risks - 0 views

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    Higher blood levels of selenium may reduce the incidence of skin cancer by about 60 per cent, according to a new study from Dutch and Australian researchers.
    Writing in Cancer Epidemiology, Biomarkers & Prevention, the researchers report that the mineral was associated with reduced risks of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

    On the other hand, blood levels of carotenoids and alpha-tocopherol (vitamin E) were not associated with any influence on skin cancer risks, report the researchers from Queensland Institute of Medical Research, the University of Queensland, and Maastricht University.
Matti Narkia

Selenium and immunocompetence in patients with head and neck cancer. - Biol Trace Elem ... - 0 views

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    Selenium and immunocompetence in patients with head and neck cancer.
    Kiremidjian-Schumacher L, Roy M, Glickman R, Schneider K, Rothstein S, Cooper J, Hochster H, Kim M, Newman R.
    Biol Trace Elem Res. 2000 Feb;73(2):97-111.
    PMID: 11049203
    DOI: 10.1385/BTER:73:2:97
Matti Narkia

Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 su... - 0 views

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    Lim YC, Lee SH, Song MH, Yamaguchi K, Yoon JH, Choi EC, Baek SJ.
    Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells.
    Eur J Cancer. 2006 Dec;42(18):3260-6. Epub 2006
Matti Narkia

Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz... - 0 views

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    Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X.
    Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge
Matti Narkia

Erbitux Increases Overall Survival For Head And Neck Cancer Patients - 0 views

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    Erbitux (Cetuximab), a new drug which is used in combination with chemotherapy, increases overall survival in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck, according to ImClone, the company which introduced the dr
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