This interaction may be a result
of the promotion of lipolysis in abdominal adipose tissue by testosterone, which may in turn cause reduced abdominal adiposity.
On the other hand, given that adipose tissue has a higher concentration of the enzyme aromatase, it could be that increased
adipose tissue results in more testosterone being converted to estrogen, thereby causing hypogonadism. Third, increased abdominal
obesity may cause reduced testosterone secretion by negatively affecting the hypothalamus‐pituitary‐testicular axis. Finally,
testosterone may be the key factor in activating the enzyme 11‐hydroxysteroid dehydrogenase in adipose tissue, which transforms
glucocorticoids into their inactive form.