lower 25(OH)D level was significantly associated with lower total T, E2, SHBG, LH and FSH levels after adjusting for age, residence area, economic status and current smoker
Group items matching
in title, tags, annotations or url
1More
Low-Fat High-Fiber Diet Decreased Serum and Urine Androgens in Men: The Journal of Clin... - 0 views
press.endocrine.org/...jc.2004-1530
diet nutrition Testosterone androgens men hormones male hormones
shared by Nathan Goodyear on 21 Sep 16
- No Cached
1More
Treatment of Men for "Low Testosterone": A Systematic Review - 0 views
www.ncbi.nlm.nih.gov/...PMC5031462
low T low Testosterone Testosterone Testosterone therapy disease male hormones
shared by Nathan Goodyear on 09 Jan 17
- No Cached
-
Systematic review finds very little clinical benefit from Testosterone therapy. The problem here is one typically made by allopathic medicine. They look for a benefit in a box. They look for one therapy to cure all. Testosterone therapy should be the last thing you prescribe as usually low Testosterone is the effect and early is not the cause. Clearly, in the right individual, Testosterone therapy can have tremendous positive effects; however, it must accompany nutrition, exercise, inflammation control... Testosterone is just one piece of a very complex male physiologic puzzle.
10More
Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from... - 0 views
-
association between 25(OH)D status and hypogonadism in Chinese men and confirms that this relationship is present in a large population
- ...6 more annotations...
-
Another mouse study reported a tendency towards low testosterone/LH ratio and Leydig cell hyperplasia in VDR null mice
-
The serum testosterone levels could increase to normal values in vitamin D-deficient rats replete with vitamin D
-
VDR knockout mice had decreased sperm count, reduced sperm motility, and histological abnormality of the testis
-
The data from the European Male Ageing Study [9] indicated that 25(OH)D is positively associated with total T
1More
Comparative pharmacokinetics of three d - PubMed Mobile - 0 views
www.ncbi.nlm.nih.gov/...9709942
DHT dihdyrotestosterone androgen replacement therapy treatment male men
shared by Nathan Goodyear on 23 Apr 12
- No Cached
1More
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implicat... - 0 views
-
discussion of the declining levels of androgens in the aging male. But the focus of this entire article is wrong. They are focusing on the blood levels of these androgens. The biological effects of hormones occur in tissue not blood. Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.
25More
PLOS ONE: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Ther... - 0 views
www.plosone.org/...10.1371%2Fjournal.pone.0085805
Testosterone therapy cardiovascular disease men male hormones
shared by Nathan Goodyear on 30 Jan 14
- No Cached
-
In men aged 65 years and older the RR was 2.19 (1.27, 3.77), while in men under age 65 years the RR was 1.17
- ...20 more annotations...
-
For TT prescription, in men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease and 0.90 (0.61, 1.34) for those without
-
In men aged 65 year and older, the RR was 2.16 (0.92, 5.10) for those with a history of heart disease and 2.21 (1.09, 4.45) for those without.
-
Among men aged 65 years and older, we observed a two-fold increase in the risk of MI in the 90 days after filling an initial TT prescription
-
Among younger men with a history of heart disease, we observed a two to three-fold increased risk of MI in the 90 days following an initial TT prescription and no excess risk in younger men without such a history
-
Among older men, the two-fold increased risk was associated with TT prescription regardless of cardiovascular disease history
-
our own findings appear consistent with a higher frequency of thrombotic events following TT prescription among men with more extensive coronary vascular disease.
-
Our findings are consistent with a recent meta-analysis of placebo-controlled randomized trials of testosterone therapy lasting 12 or more weeks among mainly older men, which reported that testosterone therapy increased the risk of adverse cardiovascular-related events (OR = 1.54, 95%CI:1.09, 2.18), as well as serious adverse cardiovascular-related events (OR = 1.61, 95%CI:1.01, 2.56) which included myocardial infarction along with other conditions
-
This association appeared unrelated to average baseline testosterone level (p = 0.70) but varied by source of funding (p = 0.03), with a stronger summary effect in a meta-analysis of studies not funded by the pharmaceutical industry (OR = 2.06, 95%CI:1.34, 3.17) compared with studies funded by the pharmaceutical industry
-
the evidence supports an association between testosterone therapy and risk of serious, adverse cardiovascular-related events–including non-fatal myocardial infarction–in men
-
there is some evidence that low endogenous testosterone levels may also be positively associated with cardiovascular events
-
effects of endogenous and exogenous testosterone may differ. Exogenous testosterone (TT) is associated with physiologic changes that predispose to clotting and thrombotic disorders including increased blood pressure [18], polycythemia [19], reductions in HDL cholesterol [18], [20], and hyperviscosity of the blood and platelet aggregation. [20]–[23]; TT also increases circulating estrogens [24], [25] which may play a role in the observed excess of adverse cardiovascular-related events, given that estrogen therapy has been associated with this excess in both men and women
-
Recently TT has been increasing extraordinarily rapidly, including among younger men and among those without hormone measurement
1More
Association between hypogonadism, symptom burden, and... [Cancer. 2014] - PubMed - NCBI - 0 views
1More
Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...12736278
gynecomastia Man Boobs hypogonadotropic hypogonadism low T Testosterone aromatase estrogen estradiol men male hormone hormones
shared by Nathan Goodyear on 03 Mar 14
- No Cached
1More
Male anorgasmia treated with oxytocin. [J Sex Med. 2008] - PubMed - NCBI - 0 views
1More
Low serum testosterone and mortali... [Arch Intern Med. 2006 Aug 14-28] - PubMed - NCBI - 0 views
70More
Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Lite... - 0 views
-
Low endogenous bioavailable testosterone levels have been shown to be associated with higher rates of all‐cause and cardiovascular‐related mortality.39,41,46–47 Patients suffering from CAD,13–18 CHF,137 T2DM,25–26 and obesity27–28
-
have all been shown to have lower levels of endogenous testosterone compared with those in healthy controls. In addition, the severity of CAD15,17,29–30 and CHF137 correlates with the degree of testosterone deficiency
-
In patients with CHF, testosterone replacement therapy has been shown to significantly improve exercise tolerance while having no effect on LVEF
- ...66 more annotations...
-
testosterone therapy causes a shift in the skeletal muscle of CHF patients toward a higher concentration of type I muscle fibers
-
Testosterone replacement therapy has also been shown to improve the homeostatic model of insulin resistance and hemoglobin A1c in diabetics26,68–69 and to lower the BMI in obese patients.
-
Lower levels of endogenous testosterone have been associated with longer duration of the QTc interval
-
negative correlation has been demonstrated between endogenous testosterone levels and IMT of the carotid arteries, abdominal aorta, and thoracic aorta
-
These findings suggest that men with lower levels of endogenous testosterone may be at a higher risk of developing atherosclerosis.
-
Current guidelines from the Endocrine Society make no recommendations on whether patients with heart disease should be screened for hypogonadism and do not recommend supplementing patients with heart disease to improve survival.
-
The Massachusetts Male Aging Study also projects ≈481 000 new cases of hypogonadism annually in US men within the same age group
-
since 1993 prescriptions for testosterone, regardless of the formulation, have increased nearly 500%
-
Testosterone levels are lower in patients with chronic illnesses such as end‐stage renal disease, human immunodeficiency virus, chronic obstructive pulmonary disease, type 2 diabetes mellitus (T2DM), obesity, and several genetic conditions such as Klinefelter syndrome
-
A growing body of evidence suggests that men with lower levels of endogenous testosterone are more prone to develop CAD during their lifetimes
-
There are 2 major potential confounding factors that the older studies generally failed to account for. These factors are the subfraction of testosterone used to perform the analysis and the method used to account for subclinical CAD.
-
The biologically inactive form of testosterone is tightly bound to SHBG and is therefore unable to bind to androgen receptors
-
The biologically inactive fraction of testosterone comprises nearly 68% of the total testosterone in human serum
-
The biologically active subfraction of testosterone, also referred to as bioavailable testosterone, is either loosely bound to albumin or circulates freely in the blood, the latter referred to as free testosterone
-
It is estimated that ≈30% of total serum testosterone is bound to albumin, whereas the remaining 1% to 3% circulates as free testosterone
-
it can be argued that using the biologically active form of testosterone to evaluate the association with CAD will produce the most reliable results
-
English et al14 found statistically significant lower levels of bioavailable testosterone, free testosterone, and free androgen index in patients with catheterization‐proven CAD compared with controls with normal coronary arteries
-
patients with catheterization‐proven CAD had statistically significant lower levels of bioavailable testosterone
-
In conclusion, existing evidence suggests that men with CAD have lower levels of endogenous testosterone,13–18 and more specifically lower levels of bioavailable testosterone
-
In a meta‐analysis of these 7 population‐based studies, Araujo et al41 showed a trend toward increased cardiovascular mortality associated with lower levels of total testosterone, but statistical significance was not achieved (RR, 1.25
-
the authors showed that a decrease of 2.1 standard deviations in levels of total testosterone was associated with a 25% increase in the risk of cardiovascular mortality
-
the relative risk of all‐cause mortality in men with lower levels of total testosterone was calculated to be 1.35
-
higher risk of cardiovascular mortality is associated with lower levels of bioavailable testosterone
-
Existing evidence seems to suggest that lower levels of endogenous testosterone are associated with higher rates of all‐cause mortality and cardiovascular mortality
-
studies have shown that lower levels of endogenous bioavailable testosterone are associated with higher rates of all‐cause and cardiovascular mortality
-
It may be possible that using bioavailable testosterone to perform mortality analysis will yield more accurate results because it prevents the biologically inactive subfraction of testosterone from playing a potential confounding role in the analysis
-
In more recent studies, 3 randomized, placebo‐controlled trials demonstrated that administration of testosterone improves myocardial ischemia in men with CAD
-
The improvement in myocardial ischemia was shown to occur in response to both acute and chronic testosterone therapy and seemed to be independent of whether an intravenous or transdermal formulation of testosterone was used.
-
There is growing evidence from in vivo animal models and in vitro models that testosterone induces coronary vasodilation by modulating the activity of ion channels, such as potassium and calcium channels, on the surface of vascular smooth muscle cells
-
Experimental studies suggest that the most likely mechanism of action for testosterone on vascular smooth muscle cells is via modulation of action of non‐ATP‐sensitive potassium ion channels, calcium‐activated potassium ion channels, voltage‐sensitive potassium ion channels, and finally L‐type calcium ion channels
-
Corona et al confirmed those results by demonstrating that not only total testosterone levels are lower among diabetics, but also the levels of free testosterone and SHBG are lower in diabetic patients
-
Laaksonen et al65 followed 702 Finnish men for 11 years and demonstrated that men in the lowest quartile of total testosterone, free testosterone, and SHBG were more likely to develop T2DM and metabolic syndrome.
-
Vikan et al followed 1454 Swedish men for 11 years and discovered that men in the highest quartile of total testosterone were significantly less likely to develop T2DM
-
authors demonstrated a statistically significant increase in the incidence of T2DM in subjects receiving gonadotropin‐releasing hormone antagonist therapy. In addition, a significant increase in the rate of myocardial infarction, stroke, sudden cardiac death, and development of cardiovascular disease was noted in patients receiving antiandrogen therapy.67
-
Several authors have demonstrated that the administration of testosterone in diabetic men improves the homeostatic model of insulin resistance, hemoglobin A1c, and fasting plasma glucose
-
Existing evidence strongly suggests that the levels of total and free testosterone are lower among diabetic patients compared with those in nondiabetics
-
insulin seems to be acting as a stimulant for the hypothalamus to secret gonadotropin‐releasing hormone, which consequently results in increased testosterone production. It can be argued that decreased stimulation of the hypothalamus in diabetics secondary to insulin deficiency could result in hypogonadotropic hypogonadism
-
This interaction may be a result of the promotion of lipolysis in abdominal adipose tissue by testosterone, which may in turn cause reduced abdominal adiposity. On the other hand, given that adipose tissue has a higher concentration of the enzyme aromatase, it could be that increased adipose tissue results in more testosterone being converted to estrogen, thereby causing hypogonadism. Third, increased abdominal obesity may cause reduced testosterone secretion by negatively affecting the hypothalamus‐pituitary‐testicular axis. Finally, testosterone may be the key factor in activating the enzyme 11‐hydroxysteroid dehydrogenase in adipose tissue, which transforms glucocorticoids into their inactive form.
-
increasing age may alter the association between testosterone and CRP. Another possible explanation for the association between testosterone level and CRP is central obesity and waist circumference
-
Bai et al have provided convincing evidence that testosterone might be able to shorten the QTc interval by augmenting the activity of slowly activating delayed rectifier potassium channels while simultaneously slowing the activity of L‐type calcium channels
-
Intima‐media thickness (IMT) of the carotid artery is considered a marker for preclinical atherosclerosis
-
Studies have shown that levels of endogenous testosterone are inversely associated with IMT of the carotid artery,126–128,32,129–130 as well as both the thoracic134 and the abdominal aorta
-
1 study has demonstrated that lower levels of free testosterone are associated with accelerated progression of carotid artery IMT
-
another study has reported that decreased levels of total and bioavailable testosterone are associated with progression of atherosclerosis in the abdominal aorta
-
These findings suggest that normal physiologic testosterone levels may help to protect men from the development of atherosclerosis
-
Czesla et al successfully demonstrated that the muscle specimens that were exposed to metenolone had a significant shift in their composition toward type I muscle fibers
-
Type I muscle fibers, also known as slow‐twitch or oxidative fibers, are associated with enhanced strength and physical capability
-
It has been shown that those with advanced CHF have a higher percentage of type II muscle fibers, based on muscle biopsy
-
Studies have shown that men with CHF suffer from reduced levels of total and free testosterone.137 It has also been shown that reduced testosterone levels in men with CHF portends a poor prognosis and is associated with increased CHF mortality.138 Reduced testosterone has also been shown to correlate negatively with exercise capacity in CHF patients.
-
Testosterone replacement therapy has been shown to significantly improve exercise capacity, without affecting LVEF
-
the results of the 3 meta‐analyses seem to indicate that testosterone replacement therapy does not cause an increase in the rate of adverse cardiovascular events
-
Data from 3 meta‐analyses seem to contradict the commonly held belief that testosterone administration may increase the risk of developing prostate cancer
-
One meta‐analysis reported an increase in all prostate‐related adverse events with testosterone administration.146 However, when each prostate‐related event, including prostate cancer and a rise in PSA, was analyzed separately, no differences were observed between the testosterone group and the placebo group
-
the existing data from the 3 meta‐analyses seem to indicate that testosterone replacement therapy does not increase the risk of adverse cardiovascular events
-
the authors correctly point out the weaknesses of their study which include retrospective study design and lack of randomization, small sample size at extremes of follow‐up, lack of outcome validation by chart review and poor generalizability of the results given that only male veterans with CAD were included in this study
-
-
-
the studies that failed to find an association between testosterone and CRP used an older population group
-
low testosterone may influence the severity of CAD by adversely affecting the mediators of the inflammatory response such as high‐sensitivity C‐reactive protein, interleukin‐6, and tumor necrosis factor–α
-
Good review of Testosterone and CHD. Low T is associated with increased all cause mortality and cardiovascular mortality, CAD, CHF, type II diabetes, obesity, increased IMT, increased severity of CAD and CHF. Testosterone replacement in men with low T has been shown to improve exercise tolerance in CHF, improve insulin resistance, improve HgbA1c and lower BMI in the obese.
1More
Blastocystis hominis and Endolimax nana Co-Infection Resulting in Chronic Diarrhea in a... - 0 views
1More
Performance of Massachusetts Male Aging Study (MM... [Aging Male. 2014] - PubMed - NCBI - 0 views
1More
Reproductive and developmental effects of p... [Crit Rev Toxicol. 2014] - PubMed - NCBI - 0 views
2More
Male hypogonadism and metabolic syndrome. [Andrologia. 2014] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...25040289
low T low Testosterone low T Testosterone metabolic syndrome men male hormone hormones
shared by Nathan Goodyear on 22 Jul 14
- No Cached
-
male hypogonadism was an independent risk factor for MS (P < 0.001). We conclude that low testosterone level plays a central role in the development of metabolic syndrome
1More
Testicular Synthesis and Vitamin D Action: The Journal of Clinical Endocrinology & Meta... - 0 views
press.endocrine.org/...jc.2014-1690
vitamin d vitamin D Testosterone men male hormone hormones cholecalciferol
shared by Nathan Goodyear on 07 Oct 14
- No Cached
3More
Salivary testosterone: a reliable approach to the ... [Clin Endocrinol (Oxf). 2007] - P... - 0 views
-
Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a noninvasive approach in the diagnosis of male androgen deficiency.
-
A cut-off value of Sal-T < or = 0.195 nm showed 100% sensibility and specificity to rule out hypogonadism.
1More
Expression of proinflammatory genes during estrogen-induced inflammation of the rat pro... - 0 views
www.ncbi.nlm.nih.gov/...10861753
inflammation IL-1beta IL-6 MIP-2 cytokines prostate estrogen estradiol male hormones
shared by Nathan Goodyear on 15 Sep 15
- No Cached
1More
Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views
www.ncbi.nlm.nih.gov/...15215045
estrogen estradiol prostate inflammation cytokines male men hormones
shared by Nathan Goodyear on 15 Sep 15
- No Cached