Thus, while glucose metabolism is negatively regulated by phosphofructokinase, fructose can continuously enter the glycolytic pathway. Therefore, fructose can uncontrollably produce glucose,
glycogen, lactate, and pyruvate, providing both the glycerol and acyl portions of
acyl-glycerol molecules. These particular substrates, and the resultant excess energy
flux due to unregulated fructose metabolism, will promote the over-production of TG
(reviewed in [53]).