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Nathan Goodyear

Selenium in Human Health and Disease | Abstract - 0 views

online.liebertpub.com/...ars.2010.3275

selenium Se disease health prostate cancer GI cancer cancer diabetes CVD cardiovascular disease

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Selenium deficiency has important implications in disease: including CVD, GI cancer, prostate cancer, and diabetes.
Nathan Goodyear

Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study - 0 views

ajcn.nutrition.org/...1160.full

nutrition diet glycemic index glycemic load cancer breast cancer carbohydrates sugar menopause women premenopause

shared by Nathan Goodyear on 09 Dec 14 - No Cached
  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
  • Nathan Goodyear on 09 Dec 14
     
    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
Nathan Goodyear

Thymidine kinase in breast cancer. - 0 views

www.ncbi.nlm.nih.gov/...PMC1971480

thymidine kinase 1 TK-1cancer

shared by Nathan Goodyear on 11 Feb 15 - No Cached
  • Nathan Goodyear on 11 Feb 15
     
    Thymidine kinase is a good marker for DNA synthesis and proliferative activity in cancer. Healthy controls had low TK-1 levels. In contrast, advancing stage of disease was associated with increasing TK-1 levels. TK-1 also was useful in following treatment efficacy. Inflammatory GI disease was found have TK-1 levels comparable to "healthy" controls. This is important to be able to differentiate between inflammation and a useful cancer biomarker
Nathan Goodyear

American Journal of Gastroenterology - Abstract of article: Diagnostic Precision of Fecal Calprotectin for Inflammatory Bowel Disease and Colorectal Malignancy - 0 views

www.nature.com/...ajg2007150a.html

IBD IBS inflammation gut GI Calprotectin colorectal cancer cancer inflammatory bowel disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Fecal calprotectin is found to be a much better screening test for IBD than colorectal cancer.  Though, fecal Calprotectin levels were found to be elevated in colorectal cancer compared to controls, the sensitivity and specificity was low.  In contrast, a fecal Calprotectin > 100 mg/g, in this study, was found to be specific and sensitive for IBD and excluding IBS.
Nathan Goodyear

Questions and answers on the role of faecal calprotectin as a biological marker in inflammatory bowel disease - 0 views

www.sciencedirect.com/...S1590865808001916

Calprotectin inflammation IBD colorectal cancer infection disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Calprotectin is a useful biomarker in IBD.  Colorectal cancer and GI infection can also increase fecal Calprotectin. 
Nathan Goodyear

Management of Bleeding in Patients with Advanced Cancer - 0 views

theoncologist.alphamedpress.org/...561.long

cancer bleeding octreotide

shared by Nathan Goodyear on 24 Aug 18 - No Cached
  • Nathan Goodyear on 24 Aug 18
     
    therapies to try and control GI bleeding.
Nathan Goodyear

Cross-kingdom inhibition of breast cancer growth by plant miR159 - 0 views

www.ncbi.nlm.nih.gov/...PMC4746606

cancer epigenetics nutrigenomics nutrition diet

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • MicroRNAs (miRNAs), a major family of small RNAs, are ∼23 nt-long single strands of RNA that bind to mRNA transcripts to inhibit their translation
  • A recent study by Zhang et al. reported that plant-derived miRNAs can be found in human serum.
  • The group demonstrates that the plant miRNA miR168 may be taken up through dietary intake to inhibit the expression of its target low-density lipoprotein receptor 1 in the liver21, providing the first evidence that miRNA in food may influence gene expression in mammalian organs.
  • ...6 more annotations...
  • A more recent finding by the same group shows that a plant miRNA from honeysuckle is able to inhibit Influenza A replication22, indicating that plant miRNAs may be useful for treating human diseases.
  • We found that plant miR159 could be detected in human sera and its levels were inversely correlated with BC incidence and progression.
  • We further identified TCF7 as a mammalian target for miR159 and showed the anti-proliferative function of miR159 in BC cells using in vitro and in vivo models, demonstrating for the first time that a plant miRNA is able to influence BC cell growth.
  • certain dietary miRNAs from plants and other species may serve as highly affordable and powerful means of treatment with minimal inconvenience to patients.
  • miR159 which (using a synthetic mimic) targets TCF7 to inhibit the proliferation of cells whose growth is dependent on TCF7 such as the BC cells MDA-MB-231
  • our study using a BC model clearly indicates the anti-tumor effect of orally administered synthetic miR159 in its naturally existing form with the plant-specific 2'-O-methylation, suggesting the feasibility of using synthetic forms of plant miRNAs as dietary supplements in the treatment of human cancers, including those outside of the GI track
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found to exist in human serum from gut absorption to then alter genetic expression in in-vitro and in vivo studies.
Nathan Goodyear

We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC6130910

glutamine DON dosing cancer

shared by Nathan Goodyear on 17 Mar 24 - No Cached
  • Glutamine is the most abundant amino acid in blood
  • Rapidly proliferating healthy cells (GI epithelium, lymphocytes) or cells under physiologic stress have increased demand for glutamine
  • Glutamine is transported into cells by one of multiple amino acid transporters (e.g. ASCT2, BOAT2), several of which are thought to be upregulated in cancer cells
  • ...10 more annotations...
  • it is hydrolyzed to glutamate and ammonia by glutaminase (‘glutaminolysis’)
  • Glutamate, produced from glutamine by glutaminase and glutamine amidotransferase activities, may be further metabolized to alpha ketoglutarate and provide a carbon skeleton source for the mitochondrial tricarboxylic acid cycle (TCA cycle)
  • Glutamine-derived glutamate is also involved in the synthesis of the reducing equivalent glutathione, vital to maintaining cellular redox status
  • Many tumors become largely dependent on glutamine to provide carbon and nitrogen building blocks needed for proliferation
  • In cancer model systems, Eagle and colleagues first demonstrated tumor cells in culture require supplementation with exogenous glutamine for efficient proliferation
  • It was subsequently shown that when deprived of glutamine tumor cells undergo apoptosis
  • The most well-characterized oncogene to regulate glutamine metabolism is MYC (9), which enhances glutaminase expression, upregulates glutamine transporters, and enhances glutamine utilization in energy production and biosynthesis
  • Other pro-tumorigenic regulators such as KRAS and mTOR, as well as tumor suppressors (p53, VHL) have also been associated with alterations in glutamine metabolism
  • Tumor cells are highly adaptable and alter nutrient uptake and metabolic networks to resist single agent glutaminase inhibition
  • cells in the microenvironment of several tumor types upregulate glutamine production, thereby enabling tumor cells to escape glutaminase inhibition
Nathan Goodyear

Chemotherapy-driven dysbiosis in the intestinal microbiome. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26147207

gut gut flora gut microbiome gut microbiota chemotherapy cancer prostate men hormone hormones Testosterone

shared by Nathan Goodyear on 07 Jul 15 - No Cached
  • Nathan Goodyear on 07 Jul 15
     
    Gut microbiome effected by chemotherapy and the result is GI mucositis.  A decrease in Firmicutes and Actinobacteria was found.
Nathan Goodyear

Gut flora in health and disease. [Lancet. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12583961

health gut flora microbiota disease GI cancer inflammation

shared by Nathan Goodyear on 05 Apr 12 - No Cached
  • Nathan Goodyear on 05 Apr 12
     
    alterations in gut microbiota linked to many diseases.  Health or disease starts in the gut!
trungtamnamkhoa

Foreskin Sign Of What Disease? Treatment - 0 views

trungtamnamkhoa.com/-quy-dau-dau-hieu-benh-gi.html

hormones cancer hormone Testosterone inflammation Men Male Disease health healthy

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Causes of itching For men, the cause of the itch can be divided into three groups: * The "little boy" hygiene is not right: Men - especially young people - often do not focus or "lazy" to clean the boy. This bad habit has gradually created an environment for the growth of genital fungi, causing an itching sensation. Besides, the selection of inappropriate cleaning solutions is also the reason that may be encountered in men. Some men reported using feminine cleaning solutions or shower gels to "bath" their "boy". This makes the itching condition more and more because the nature of the feminine hygiene solution is not suitable for his small skin, so it can easily lead to skin irritation, even leading to a disorder of the skin and creating favorable conditions for mushroom growth.
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