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Nathan Goodyear

Decreased bioavailability of vitamin D in obesity - 0 views

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    Obesity is associated with decreased vitamin D3 levels. One would think that an increase in surface area would increase Vitamin D levels, but actually, the increase in fat accumulates the fat soluble vitamin D3.
Nathan Goodyear

Bioavailability of Vitamin D2 and D3 in Healthy Volunteers, a Randomized Placebo-Controlled Trial - 0 views

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    Vitamin D3 is better than D2.  Vitamin D3 replacement raised 25(OH)D, whereas vitamin D2 caused a decline in levels.
Nathan Goodyear

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren - 0 views

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    Nice study from a few years ago found that a low dose vitamin D3 (1200 IU) significantly reduced the relative risk of the flu in school age children.  Also of note, a significant reduction in asthma attacks in those children with asthma were significantly reduced in the vitamin D3 treated group.  One interesting thing about this study was that they did not check prior or during the study if vitamin D deficiency was even present.  This study was conducted in Japan
Nathan Goodyear

Vitamin D may help lower blood pressure - UPI.com - 0 views

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    European study showed that vitamin D replacement in those with low vitamin D levels, had benefits of lowered blood pressure.
Nathan Goodyear

Epidemic influenza and vitamin D. [Epidemiol Infect. 2006] - PubMed - NCBI - 0 views

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    vitamin D deficiency predisposes children to the respiratory problems commonly found in the winter months.  Vitamin D shown to reduce the incidence of such respiratory infections (cold, flu...)
Nathan Goodyear

BMC Public Health | Abstract | High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia - 0 views

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    Malaysians with metabolic syndrome and obesity found to have high prevalence of vitamin D insufficiency.  Role for vitamin D therapy for those with metabolic syndrome and obesity.
Nathan Goodyear

Vitamin D role and use in prediabetes. [Endocr Pract. 2010 May-Jun] - PubMed - NCBI - 0 views

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    vitamin D therapy shown to improve insulin resistance.  Vitamin D insufficiency (< 30 ng/ml) found in 77% of Americans
Nathan Goodyear

PLOS ONE: Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials - 0 views

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    Vitamin D supplementation finds no increased risk on breast cancer risk.  This is a negative study (meta-analysis) on vitamin D and breast cancer in postmenopausal women.  The strength of evidence lies with positive effects as numerous studies are documented in diigo here.
Nathan Goodyear

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation - 0 views

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    Vitamin D support provides benefit in those with Lupus.  The proposed mechanism is through the balance of Treg cells and Th17 cells.  This imbalance plays a role in the etiology of autoimmune disease and those with autoimmune disease, such as in Lupus, frequently have low vitamin D levels.
Nathan Goodyear

Blood levels of vitamin D and early ... [Breast Cancer Res Treat. 2013] - PubMed - NCBI - 0 views

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    low vitamin D associated with breast cancer recurrence and mortality.
Nathan Goodyear

Testicular Synthesis and Vitamin D Action: The Journal of Clinical Endocrinology & Metabolism: Vol 99, No 10 - 0 views

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    Cholecalciferol (vitamin D3) was found to increase male Testosterone production in cell culture model.  This fits with other data that low vitamin D and low T often go hand in hand.  This study actually shows improved D levels increase Testicular Testosterone production, though in cell culture.
Nathan Goodyear

Effects of calcium-vitamin D co-supplementation... [Diabetologia. 2014] - PubMed - NCBI - 0 views

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    vitamin D plus calcium in those with Diabetes and low vitamin D four to improve insulin resistance, HDL, LDL, beta cell function, and HgbA1c.  This was a short course study of 8 weeks.  Only abstract available.
Nathan Goodyear

Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate - Lambert - 2014 - The Prostate - Wiley Online Library - 0 views

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    Vitamin D again implicated in cancer.  This time prostate cancer.  Study found that vitamin D regulates the expression of GDF-15 which inhibits NF-kappaB.  Low vitamin D leads to decreased GDF-15 expression which leads to increased NF-kappaB transcription and resultant inflammation.
Nathan Goodyear

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis - 0 views

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    High dose vitamin D (10,400 IU) found to reduce IL-17, CD161 and effector memory cells; in contrast low dose vitamin D (800 IU)  did not.  The study also called into question the traditional target range of vitamin D.  The authors here proposed 40-60
Nathan Goodyear

Vitamin D and Acute Myeloid Leukemia | IntechOpen - 0 views

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    low vitamin D associated with poor outcomes in hematologic cancers. This chapter reviews several studies that highlight the link with low vitamin D and poor outcomes in AML patients.
Nathan Goodyear

A Vitamin B-12 Supplement of 500 μg/d for Eight Weeks Does Not Normalize Urinary Methylmalonic Acid or Other Biomarkers of Vitamin B-12 Status in Elderly People with Moderately Poor Vitamin B-12 Status - 0 views

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    current vitamin B12 recommendations are too low.  Proper vitamin B12 biomarker testing reveals this fact. The problem is most people fall prey to the lack of knowledge behind simple serum levels.  Simple B12 serum levels are woefully inadequate. Insurance would rather one stay with inadequate testing to save money, rather than actually read the science to learn about new testing.
Nathan Goodyear

Vitamin D Deficiency Modulates Graves' Hyperthyroidism Induced in BALB/c Mice by Thyrotropin Receptor Immunization - 0 views

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    Low vitamin D plays a role in immune response associated with Graves disease.  This study found small impact, but impact nonetheless.
Nathan Goodyear

PLOS Medicine: Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts - 0 views

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    Study finds that obesity is linked to lower vitamin D.  Not that there is merely an association, but that the elevated BMI is the cause of lower vitamin D levels.
Nathan Goodyear

Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia - 0 views

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    vitamin D deficiency increases preeclampsia risk.  All pregnant women or women considering pregnancy should be evaluated for vitamin D deficiency.
Nathan Goodyear

Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoimmune diseases: a short review, Expert Review of Respiratory Medicine, Expert Reviews - 0 views

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    Vitamin D is an important immunomodulator.  Vitamin D shown to have benefit in Th1 and Th2 mediated disease states. Asthma and COPD benefit and other Th1 mediated diseases, such as MS, type 1 Diabetes, RA...
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