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Nathan Goodyear

Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC1892114

xenoestrogens bisphenol A estrogen hormone hormones androgen receptor receptors estrogen receptor prostate

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    Great read on the effects of bisphenol A as an xenoestrogen.  bisphenol A is a weak estrogen, but it does increase androgen receptor and estrogen receptor alpha transcription.  This is from fetal exposure.
Nathan Goodyear

Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein-Coupled Estrogen Receptor - 0 views

www.ncbi.nlm.nih.gov/...PMC2717129

Bisphenol-A xenoestrogens xenoestrogen hormone hormones

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A: review of the different biochemical effects of Bisphenol A.
Nathan Goodyear

Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Receptor-α-Positive and -Negative Breast Cancer Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC2649216

ER-alpha estrogen receptor Bisphenol A toxins cancer breast

shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.
Nathan Goodyear

Association between urinary levels of bisp... [Sci Total Environ. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23954212

bisphenol A Bisphenol-A BPA estrogen metabolism hormone hormones xenoestrogens xenoestrogen

shared by Nathan Goodyear on 19 Jun 14 - No Cached
  • Nathan Goodyear on 19 Jun 14
     
    Bisphenol A (BPA) negatively effects estrogen metabolism. Bisphenol A preferentially increases 4OH-estrone which is the most toxic estrogen metabolite.
Nathan Goodyear

Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes - 0 views

www.pnas.org/...1203574109.abstract

BPA bisphenol A ER estrogen receptor agonist hormone hormones

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    bisphenol A is a estrogen receptor agonist, though partial.
Nathan Goodyear

Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormone Levels in Men from an Infertility Clinic - Environmental Science & Technology (ACS Publications) - 0 views

pubs.acs.org/...es9028292

BPA Bisphenol-A bisphenol infertility men's health men E2:T free androgen index hypothyroidism TSH low T testosterone

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
Nathan Goodyear

Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol 10.1016/j.toxlet.2010.02.002 : Toxicology Letters | ScienceDirect.com - 0 views

www.sciencedirect.com/...S0378427410000561

testosterone Bisphenol-A Bisphenol A BPA low T leydig cells pituitary

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Bisphenol-A inhibits testosterone production through direct inhibition of the pituitary and the leydig cells.  This is similar to the way E2 acts on the the pituitary and the leydig cells.  
Nathan Goodyear

Bisphenol A and human health: A review of the... [Reprod Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23994667

bisphenol A Bisphenol-A BPA endocrine disruptor xenoextrogen

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Bisphenol A proving to be an significant endocrine disruptor in humans.
Nathan Goodyear

Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-Reductase Isozymes in Rat Prostate - 0 views

www.ncbi.nlm.nih.gov/...PMC3566099

bisphenol A Bisphenol-A BPA toxin prostate disease

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    animal model, but Bisphenol A shown to increase aromatase production.  This aids the decreased T:E2 ratio that is commonly found in prostate disease.  So, BPA is a xenoestrogen.  BPA is an androgen receptor antagonist and BPA increases aromatase activity.  
Nathan Goodyear

Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of female mice - 0 views

joe.endocrinology-journals.org/...201.abstract

bisphenol A Bisphenol-A BPA kisspeptin LH FSH Estradiol estrogen hormones female

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Mouse model finds that Bisphenol A (BPA) induces LH/FSH and Estradiol production through kisspeptin stimulation.
Nathan Goodyear

Bisphenol A Effects on Estrogen Receptor β Expression: Implications in Prostate Cancer - 0 views

www.niehs.nih.gov/...index.cfm

BPA bisphenol A ER-beta prostate estrogen receptors ER estrogen receptors cancer

shared by Nathan Goodyear on 21 Nov 12 - No Cached
  • Nathan Goodyear on 21 Nov 12
     
    Bisphenol A downgregulates ER-beta in male prostate.  This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications  in prostate health.
Nathan Goodyear

Exposure to the environmental estrogen bisphenol A ... [Life Sci. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12505546

Bisphenol-A ER alpha ER beta estrogen receptor estrogen receptor alpha estrogen receptor beta hormone hormones

shared by Nathan Goodyear on 14 May 13 - No Cached
  • Nathan Goodyear on 14 May 13
     
    Bisphenol A causes shift in ER-beta to ER-alpha through increase ER alpha transcription in the testis.  This only looked at ER expression in the testis.
Nathan Goodyear

Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC1892114

environmental toxins environment bisphenol A inflammation cancer estrogen receptors androgen receptors ER AR estrogen receptors androgen hormone hormones

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    environmental toxin, bisphenol A, shown to increase estrogen receptor and androgen receptor expression in the prostate.  Also, a shift from ER beta to ER alpha occurs, increase the inflammatory and proliferative signal.
Nathan Goodyear

The activity of bisphenol A depends on both the est... [Endocr J. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12402979

bisphenol A ER estrogen receptor receptors hormone hormones agonist antagonist estrogen receptor BPA

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    bisphenol A is shown to be both an ER agonist and an ER antagonist.
Nathan Goodyear

Mechanism of Action of Bisphenol A and other Biochemical/Molecular interactions - 0 views

www.who.int/...ological_activities_of_bpa.pdf

Bisphenol-A xenoestrogen xenoestrogens hormone hormones estrogen receptor estrogen receptor receptors

shared by Nathan Goodyear on 08 Jan 13 - No Cached
  • Nathan Goodyear on 08 Jan 13
     
    Thorough discussion of the scientific knowledge on bisphenol A and its hormonal and receptor effects.
Nathan Goodyear

PLOS ONE: Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function - 0 views

www.plosone.org/...journal.pone.0051579

Bisphenol-A leydig cells hormone hormones testosterone xenoestrogen

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A decreases testicular testosterone production at the sight of the leydig cells.
Nathan Goodyear

Antiandrogenic effects of bisphenol A and nonylp... [Toxicol Sci. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12805653

Bisphenol-A androgen receptor antagonist androgen receptor androgen receptor hormone hormones xenoestrogens xenoestrogen

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A acts as androgen receptor antagonist.
Nathan Goodyear

Bisphenol-A acts as a potent estrogen vi... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22227557

Bisphenol-A xenoestrogen xenoestrogens hormone hormones

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A acts via non-classical genomic signaling and more through weaker non-classical membrane receptors and their secondary messengers.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
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