Contents contributed and discussions participated by Nathan Goodyear - Dr. Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

eurheartj.oxfordjournals.org/...998

endurance athletes training heart health injury

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In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
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no relationship between LV function and biomarker levels
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focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
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he cardiac impact of both acute and cumulative exercise is greatest on the RV.
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Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
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cardiac injury is greatest in the least trained
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Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
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We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
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Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
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The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
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The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
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a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
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The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
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BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
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BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
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It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
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This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
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Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
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there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
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RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
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the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
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focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
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emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
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RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
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it is premature to conclude that these changes may represent a proarrhythmic substrate
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Nathan Goodyear on 09 Jan 15

Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes. This post-race RVEF reduction is associated with VO2max.

<div class="cArrow"> </div><div class="cContentInner">Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes. This post-race RVEF reduction is associated with VO2max.</div>

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Marathons damage the hearts of less fit runners for up to three months - - Heart and St... - 0 views

www.heartandstroke.nb.ca/...content2.aspx

endurance training running runners marathon marathons heart health CVD exercise

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Nathan Goodyear on 09 Jan 15

Summary of 2010 report on marathons and the heart. Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners. V02 max is a good way to assess aerobic endurance and differentiate between the two. Dr Larose showed via MRI that it can take 3 months for the heart to recover.

<div class="cArrow"> </div><div class="cContentInner">Summary of 2010 report on marathons and the heart. Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners. V02 max is a good way to assess aerobic endurance and differentiate between the two. Dr Larose showed via MRI that it can take 3 months for the heart to recover.</div>

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The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over... - 0 views

www.ncbi.nlm.nih.gov/...PMC3155102

Dandelion diuretic natural herbs

shared by Nathan Goodyear on 07 Jan 15 - No Cached

Nathan Goodyear on 07 Jan 15

Dandelion root has historically shown benefit as diuretic. Study finds support for tincture, though this is a small pilot. Dosing is critical.

<div class="cArrow"> </div><div class="cContentInner">Dandelion root has historically shown benefit as diuretic. Study finds support for tincture, though this is a small pilot. Dosing is critical.</div>

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Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

connection.ebscohost.com/...ione-individuals-hiv-infection

glutathione GSH Nrf2 GSSG HIV inflammation oxidative Stress

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Nathan Goodyear on 07 Jan 15

men with HIV have GSH depleted macrophages. GSH is the reduced, ready to act form of Glutathione. In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG. In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.

<div class="cArrow"> </div><div class="cContentInner">men with HIV have GSH depleted macrophages. GSH is the reduced, ready to act form of Glutathione. In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG. In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.</div>

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Neuraminidase inhibitors for preventing and treating influenza in healthy adults and ch... - 0 views

onlinelibrary.wiley.com/...23A29FF11B3087DB5F71938.f03t02

flu influenza Tamiflu

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Nathan Goodyear on 07 Jan 15

Does Tamiflu work. The evidence says no. New cochrane review: "The influenza virus-specific mechanism of action proposed by the produces does not fit the clinical evidence".

<div class="cArrow"> </div><div class="cContentInner">Does Tamiflu work. The evidence says no. New cochrane review: "The influenza virus-specific mechanism of action proposed by the produces does not fit the clinical evidence".</div>

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