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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Percutaneous progesterone delivery via cream or gel application in postmenopausal women... - 0 views

www.researchgate.net/...ood_saliva_and_capillary_blood

saliva saliva testing salivary testing blood spot capillary blood progesterone hormones

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Nathan Goodyear on 22 Jun 15
     
    Topical hormones best evaluated via saliva and/or blood spot. Urine and particularly serum does not increase with dosing.  That does not mean the topical hormone therapy is ineffective, just that serum and urine are not optimal to follow topical therapy.  When looking at endogenous hormones without any therapies: serum, saliva, urine, and blood spot are equivalent.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

www.ncbi.nlm.nih.gov/...9506793

Testosterone exercise hormone hormones SHBG

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

Neuropsychopharmacology - Testosterone Suppression of CRH-Stimulated Cortisol in Men - 0 views

www.nature.com/...1300742a.html

Testosterone cortisol hormone hormones men male

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    Testosterone inhibits CRH and thus cortisol.
Nathan Goodyear

Testosterone Suppression of CRH-stimulated Cortisol in Men - 0 views

www.ncbi.nlm.nih.gov/...PMC1470424

Testosterone cortisol HPA hormone hormones men male

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    Testosterone inhibits CRH and thus cortisol production in men.  This has implications in men with low T and low Cortisol.
Nathan Goodyear

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regula... - 0 views

www.nature.com/...ncomms7266.html

Leptin HPA hormone hormones

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    Leptin does have inhibitory activity at the level at the HPA; in addition to the inhibition at the gonadal level.
Nathan Goodyear

PLOS ONE: Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecule... - 0 views

journals.plos.org/...article

testosterone dopamine hormone hormones

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • The majority of the gene expression changes reported here are only induced by DHT and testosterone, and not by estradiol, indicating that in adolescent males androgen receptor, not ERα, activation is critical for these responses
  • It is less clear whether ERβ is involved or not as DHT, via conversion to 3β-diol has a high affinity for ERβ
  • the testosterone-induced, AR-driven modulation of molecular indices of dopamine responsivity of the nigrostriatal pathway may involve regulation of dopamine feedback inhibition in the somatodendritic field and post-synaptic dopamine action in the terminal field.
  • Nathan Goodyear on 19 Jun 15
     
    Testosterone increases dopamine signaling.  This study was done on male rats.  No effect was seen with Estradiol.
Nathan Goodyear

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disea... - 0 views

ueg.sagepub.com/...294.full

vitamin D Crohn's Crohn's disease

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    vitamin D supplementation (2,000 IU) prolongs remission of Crohn's disease.  Of interesting note, the vitamin D group maintained gut integrity and had a decrease in gut permeability.
Nathan Goodyear

Age-related testosterone decline is due to waning of both testicular and hypothalamic-p... - 0 views

informahealthcare.com/...13685538.2015.1052392

low T low Testosterone Testosterone men male hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Only abstract available here, but low T is the result of primary (testicular failure) and/or secondary (HPA failure). 
Nathan Goodyear

Effects of Testosterone Level on Lower Urinary Tract Symptoms. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26077271

Testosterone LUTS prostate men hormones hormone

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    no correlation between total Testosterone with LUTS and prostate size in men.
Nathan Goodyear

Effects of Resistance Training on Testosterone Metabolism in Younger and Older Men. - P... - 0 views

www.ncbi.nlm.nih.gov/...26079649

resistance training Testosterone muscle hormone hormones men

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Resistance training increases Testosterone in younger and older men.  The effects in older men appears to involve more of a decreased metabolism.  
Nathan Goodyear

Leptin inhibits testosterone secretion from adult rat testis in vitro. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10320818

leptin Testosterone LH FSH

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    high leptin levels found to inhibit pituitary LH/FSH release.  Of note, high leptin levels inhibited leydig cell production of Testosterone following hCG stimulation.  This is a rat in vitro study.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/170/2/413.full.pdf - 0 views

joe.endocrinology-journals.org/...413.full.pdf

leptin Testosterone hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin shown to inhibit steroid hormone synthesis in the gonads via inhibition of 17beta-HSD.  This is in addition to other reports of inhibition of 17,20 lyase, adrenal cortisol inhibition, inhibition of CRF, and inhibition of LH/FSH.
Nathan Goodyear

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. - P... - 0 views

www.ncbi.nlm.nih.gov/...9275075

leptin CRH HPA axis HPA hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin inhibits CRH, thus decreasing the HPA axis.
Nathan Goodyear

Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17725965

Leptin adrenal HPA hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin inhibits hormone production from the adrenal cortex, but increases catecholamine release from the adrenal medulla.
Nathan Goodyear

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men - 0 views

www.ncbi.nlm.nih.gov/...PMC3380939

Kisspeptin kisspeptins LH Testosterone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Kisspeptin, a hypothalamic neuropeptide
  • has recently emerged as a key central regulator of GnRH secretion
  • Nathan Goodyear on 17 Jun 15
     
    Kisspeptin increases LH pulse frequency and pluse amplititude; the result is an increase in Testosterone secretion.
Nathan Goodyear

http://www.researchgate.net/profile/Costanzo_Moretti/publication/12777565_Leptin_and_an... - 0 views

www.researchgate.net/...02bfe50e5334207a93000000.pdf

leptin low T low Testosterone obese men male hormone hormones obesity

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Normal leptin levels are critical to puberty; but in obese men, increased leptin is associated with gonadal decrease in Testosterone.  It appears to occur through a decrease in 17-OH progesterone to Testosterone: suggesting an inhibitory activity in the conversion of 17-OH progesterone to Testosterone in obese men.
Nathan Goodyear

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pat... - 0 views

www.jlr.org/...S86.full

lipoprotein lipase

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Lipoprotein lipase is important in the uptake of Fatty acids into cells: particularly adipose cells and muscle cells.
Nathan Goodyear

The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...10997611

Testosterone DHEA lipoprotein lipase adipose tissue hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis
  • T inhibits differentiation of adipocyte precursor cells
  • DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane
  • ...2 more annotations...
  • The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin
  • the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue
  • Nathan Goodyear on 17 Jun 15
     
    Testosterone inhibits lipid uptake into adipocytes.  Testosterone inhibits lipoprotein lipase.  Testosterone stimulated lipolysis.  Testosterone inhibits adipocyte differentiation of proginator cells. DHEAs effects are through different mechanisms.   Both have a preference for activity with visceral adipose tissue.
Nathan Goodyear

The kisspeptin-GnRH pathway in human reproductive health and disease - 0 views

humupd.oxfordjournals.org/...humupd.dmu009.long

kisspeptin kisspeptins LH hormone hormones gonadotropins

shared by Nathan Goodyear on 16 Jun 15 - No Cached
  • Nathan Goodyear on 16 Jun 15
     
    good review of the current understanding of kisspeptin and gonadotropins.
Nathan Goodyear

http://download.springer.com/static/pdf/869/art%253A10.1007%252Fs12020-015-0650-6.pdf?o... - 0 views

download.springer.com/...1007%252Fs12020-015-0650-6.pdf

saliva salivary Testosterone Testosterone hormone hormones

shared by Nathan Goodyear on 15 Jun 15 - No Cached
  • Nathan Goodyear on 15 Jun 15
     
    Opinion publication recommends total Testosterone as primary means of evaluating Testosterone.  This recommendation relies on the use of immunoassay techniques which can lack specificity compared to newer LC/MS and GC/MS techniques.  The authors did recommend using salivary Testosterone when borderline and SHBG variables play in, which happens to be most clients I see.  The best approach is to use both simultaneously to give a more clear physiologic picture to start.
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